9Y4C
Strand displacement state I of Human mitochondrial DNA polymerase gamma ternary complex
Functional Information from PROSITE/UniProt
| site_id | PS00447 |
| Number of Residues | 20 |
| Details | DNA_POLYMERASE_A DNA polymerase family A signature. RehAKifnYGriYgaGqpfA |
| Chain | Residue | Details |
| A | ARG943-ALA962 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Region: {"description":"Trigger loop","evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Exo I","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Exo II","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Exo III","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | Motif: {"description":"Pol A","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 15 |
| Details | Motif: {"description":"Pol B","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 7 |
| Details | Motif: {"description":"Pol C","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Exonuclease activity","evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D37","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26056153","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4ZTZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26056153","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D37","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8D37","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26056153","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZTZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Site: {"description":"Critical for replication fidelity and mismatch recognition","evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
