9XZL

Cryo-EM structure of F-box helicase 1 (FBH1) bound to an SCF ubiquitin ligase complex and a 3-way DNA fork (body structure)

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006879	biological_process	intracellular iron ion homeostasis
C	0007346	biological_process	regulation of mitotic cell cycle
C	0010564	biological_process	regulation of cell cycle process
C	0010824	biological_process	regulation of centrosome duplication
C	0014033	biological_process	neural crest cell differentiation
C	0016567	biological_process	protein ubiquitination
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0030510	biological_process	regulation of BMP signaling pathway
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032006	biological_process	regulation of TOR signaling
C	0034599	biological_process	cellular response to oxidative stress
C	0042752	biological_process	regulation of circadian rhythm
C	0042981	biological_process	regulation of apoptotic process
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0050727	biological_process	regulation of inflammatory response
C	0051298	biological_process	centrosome duplication
C	0051726	biological_process	regulation of cell cycle
C	0060173	biological_process	limb development
C	0060271	biological_process	cilium assembly
C	0070936	biological_process	protein K48-linked ubiquitination
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	1901524	biological_process	regulation of mitophagy
C	1904415	biological_process	regulation of xenophagy
C	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
C	2000001	biological_process	regulation of DNA damage checkpoint
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0000785	cellular_component	chromatin
F	0001934	biological_process	positive regulation of protein phosphorylation
F	0003678	molecular_function	DNA helicase activity
F	0003690	molecular_function	double-stranded DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006281	biological_process	DNA repair
F	0006308	biological_process	DNA catabolic process
F	0006974	biological_process	DNA damage response
F	0015616	molecular_function	DNA translocase activity
F	0016567	biological_process	protein ubiquitination
F	0016887	molecular_function	ATP hydrolysis activity
F	0019005	cellular_component	SCF ubiquitin ligase complex
F	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
F	0031297	biological_process	replication fork processing
F	0043138	molecular_function	3'-5' DNA helicase activity
F	0072429	biological_process	response to intra-S DNA damage checkpoint signaling
F	1902231	biological_process	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
F	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
S	0000082	biological_process	G1/S transition of mitotic cell cycle
S	0000209	biological_process	protein polyubiquitination
S	0000785	cellular_component	chromatin
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005829	cellular_component	cytosol
S	0006338	biological_process	chromatin remodeling
S	0006355	biological_process	regulation of DNA-templated transcription
S	0006879	biological_process	intracellular iron ion homeostasis
S	0007346	biological_process	regulation of mitotic cell cycle
S	0008013	molecular_function	beta-catenin binding
S	0010564	biological_process	regulation of cell cycle process
S	0010824	biological_process	regulation of centrosome duplication
S	0014033	biological_process	neural crest cell differentiation
S	0016567	biological_process	protein ubiquitination
S	0019005	cellular_component	SCF ubiquitin ligase complex
S	0019904	molecular_function	protein domain specific binding
S	0030510	biological_process	regulation of BMP signaling pathway
S	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
S	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
S	0031507	biological_process	heterochromatin formation
S	0031519	cellular_component	PcG protein complex
S	0032006	biological_process	regulation of TOR signaling
S	0042752	biological_process	regulation of circadian rhythm
S	0042981	biological_process	regulation of apoptotic process
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0045892	biological_process	negative regulation of DNA-templated transcription
S	0050727	biological_process	regulation of inflammatory response
S	0051124	biological_process	synaptic assembly at neuromuscular junction
S	0051298	biological_process	centrosome duplication
S	0051457	biological_process	maintenance of protein location in nucleus
S	0051726	biological_process	regulation of cell cycle
S	0060173	biological_process	limb development
S	0060271	biological_process	cilium assembly
S	0070936	biological_process	protein K48-linked ubiquitination
S	0097602	molecular_function	cullin family protein binding
S	0140677	molecular_function	molecular function activator activity
S	0160072	molecular_function	ubiquitin ligase complex scaffold activity
S	1901524	biological_process	regulation of mitophagy
S	1904415	biological_process	regulation of xenophagy
S	1990444	molecular_function	F-box domain binding
S	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
S	1990757	molecular_function	ubiquitin ligase activator activity
S	2000001	biological_process	regulation of DNA damage checkpoint

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA

Chain	Residue	Details
C	ILE749-ALA776

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	263
Details	Domain: {"description":"UvrD-like helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00560","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Motif: {"description":"APIM motif","evidences":[{"source":"PubMed","id":"23677613","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00560","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	20
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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