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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9X4F

Crystal structure of tetrameric alpha-enolase with asymmetric flexible active sites

Functional Information from GO Data
ChainGOidnamespacecontents
A0000015cellular_componentphosphopyruvate hydratase complex
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
A0001222molecular_functiontranscription corepressor binding
A0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
A0003714molecular_functiontranscription corepressor activity
A0003723molecular_functionRNA binding
A0004634molecular_functionphosphopyruvate hydratase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005640cellular_componentnuclear outer membrane
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006094biological_processgluconeogenesis
A0006096biological_processglycolytic process
A0009615biological_processresponse to virus
A0009986cellular_componentcell surface
A0010756biological_processpositive regulation of plasminogen activation
A0016020cellular_componentmembrane
A0030308biological_processnegative regulation of cell growth
A0031430cellular_componentM band
A0042803molecular_functionprotein homodimerization activity
A0045296molecular_functioncadherin binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0045933biological_processpositive regulation of muscle contraction
A0051020molecular_functionGTPase binding
A0061621biological_processcanonical glycolysis
A0070062cellular_componentextracellular exosome
A1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
A2001171biological_processpositive regulation of ATP biosynthetic process
B0000015cellular_componentphosphopyruvate hydratase complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
B0001222molecular_functiontranscription corepressor binding
B0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
B0003714molecular_functiontranscription corepressor activity
B0003723molecular_functionRNA binding
B0004634molecular_functionphosphopyruvate hydratase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005640cellular_componentnuclear outer membrane
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0006094biological_processgluconeogenesis
B0006096biological_processglycolytic process
B0009615biological_processresponse to virus
B0009986cellular_componentcell surface
B0010756biological_processpositive regulation of plasminogen activation
B0016020cellular_componentmembrane
B0030308biological_processnegative regulation of cell growth
B0031430cellular_componentM band
B0042803molecular_functionprotein homodimerization activity
B0045296molecular_functioncadherin binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0045933biological_processpositive regulation of muscle contraction
B0051020molecular_functionGTPase binding
B0061621biological_processcanonical glycolysis
B0070062cellular_componentextracellular exosome
B1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
B2001171biological_processpositive regulation of ATP biosynthetic process
C0000015cellular_componentphosphopyruvate hydratase complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
C0001222molecular_functiontranscription corepressor binding
C0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
C0003714molecular_functiontranscription corepressor activity
C0003723molecular_functionRNA binding
C0004634molecular_functionphosphopyruvate hydratase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005640cellular_componentnuclear outer membrane
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005938cellular_componentcell cortex
C0006094biological_processgluconeogenesis
C0006096biological_processglycolytic process
C0009615biological_processresponse to virus
C0009986cellular_componentcell surface
C0010756biological_processpositive regulation of plasminogen activation
C0016020cellular_componentmembrane
C0030308biological_processnegative regulation of cell growth
C0031430cellular_componentM band
C0042803molecular_functionprotein homodimerization activity
C0045296molecular_functioncadherin binding
C0045892biological_processnegative regulation of DNA-templated transcription
C0045933biological_processpositive regulation of muscle contraction
C0051020molecular_functionGTPase binding
C0061621biological_processcanonical glycolysis
C0070062cellular_componentextracellular exosome
C1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
C2001171biological_processpositive regulation of ATP biosynthetic process
D0000015cellular_componentphosphopyruvate hydratase complex
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
D0001222molecular_functiontranscription corepressor binding
D0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
D0003714molecular_functiontranscription corepressor activity
D0003723molecular_functionRNA binding
D0004634molecular_functionphosphopyruvate hydratase activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005640cellular_componentnuclear outer membrane
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005938cellular_componentcell cortex
D0006094biological_processgluconeogenesis
D0006096biological_processglycolytic process
D0009615biological_processresponse to virus
D0009986cellular_componentcell surface
D0010756biological_processpositive regulation of plasminogen activation
D0016020cellular_componentmembrane
D0030308biological_processnegative regulation of cell growth
D0031430cellular_componentM band
D0042803molecular_functionprotein homodimerization activity
D0045296molecular_functioncadherin binding
D0045892biological_processnegative regulation of DNA-templated transcription
D0045933biological_processpositive regulation of muscle contraction
D0051020molecular_functionGTPase binding
D0061621biological_processcanonical glycolysis
D0070062cellular_componentextracellular exosome
D1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
D2001171biological_processpositive regulation of ATP biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00164
Number of Residues14
DetailsENOLASE Enolase signature. LLLKvNQIGSVTES
ChainResidueDetails
ALEU340-SER353
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsRegion: {"description":"Epitope recognized by CAR and healthy patient antibodies"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues28
DetailsRegion: {"description":"Epitope recognized by CAR antibodies"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues560
DetailsRegion: {"description":"Required for repression of c-myc promoter activity"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P00924","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P00924","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18560153","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P00924","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","Zebisch A.","Kolch W."]}},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues32
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues16
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P17182","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues16
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P17182","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P17182","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsModified residue: {"description":"N6-malonyllysine; alternate","evidences":[{"source":"PubMed","id":"21908771","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

260320

PDB entries from 2026-09-30

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