9X1H
Cryo-EM Structure of human complement C1s CUB domain in complex with RAY121
Functional Information from PROSITE/UniProt
| site_id | PS00010 |
| Number of Residues | 12 |
| Details | ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CnNfiggYfCsC |
| Chain | Residue | Details |
| B | CYS132-CYS143 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| I | TYR201-HIS207 | |
| L | TYR198-HIS204 |
| site_id | PS01187 |
| Number of Residues | 26 |
| Details | EGF_CA Calcium-binding EGF-like domain signature. DiNECtdfvdvp.......Cshf....CnNfiggYfC |
| Chain | Residue | Details |
| B | ASP116-CYS141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12788922","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23922389","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29311313","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NZI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"(3R)-3-hydroxyasparagine","evidences":[{"source":"PubMed","id":"2141278","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2141278","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23922389","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
