9WXV
Cryo-EM structure of TMEM63A-digitonin-cholesterol
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=TM0","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 68 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 31 |
| Details | Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 14 |
| Details | Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 31 |
| Details | Region: {"description":"Gating helix","evidences":[{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
