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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9WBD

Crystal structure of HLA-B*07:02 in complex with SPR epitope and Q04 TCR

Functional Information from GO Data
ChainGOidnamespacecontents
D0000139cellular_componentGolgi membrane
D0002376biological_processimmune system process
D0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
D0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
D0002502biological_processpeptide antigen assembly with MHC class I protein complex
D0002503biological_processpeptide antigen assembly with MHC class II protein complex
D0002715biological_processregulation of natural killer cell mediated immunity
D0002726biological_processpositive regulation of T cell cytokine production
D0005198molecular_functionstructural molecule activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005765cellular_componentlysosomal membrane
D0005783cellular_componentendoplasmic reticulum
D0005788cellular_componentendoplasmic reticulum lumen
D0005794cellular_componentGolgi apparatus
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006879biological_processintracellular iron ion homeostasis
D0007608biological_processsensory perception of smell
D0007611biological_processlearning or memory
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0010038biological_processresponse to metal ion
D0012507cellular_componentER to Golgi transport vesicle membrane
D0016020cellular_componentmembrane
D0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
D0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
D0023026molecular_functionMHC class II protein complex binding
D0030670cellular_componentphagocytic vesicle membrane
D0031901cellular_componentearly endosome membrane
D0031902cellular_componentlate endosome membrane
D0031905cellular_componentearly endosome lumen
D0033572biological_processtransferrin transport
D0034756biological_processregulation of iron ion transport
D0034757biological_processnegative regulation of iron ion transport
D0035580cellular_componentspecific granule lumen
D0042605molecular_functionpeptide antigen binding
D0042612cellular_componentMHC class I protein complex
D0042613cellular_componentMHC class II protein complex
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042824cellular_componentMHC class I peptide loading complex
D0048260biological_processpositive regulation of receptor-mediated endocytosis
D0048261biological_processnegative regulation of receptor-mediated endocytosis
D0050680biological_processnegative regulation of epithelial cell proliferation
D0050768biological_processnegative regulation of neurogenesis
D0050778biological_processpositive regulation of immune response
D0050870biological_processpositive regulation of T cell activation
D0051289biological_processprotein homotetramerization
D0055038cellular_componentrecycling endosome membrane
D0070062cellular_componentextracellular exosome
D0071281biological_processcellular response to iron ion
D0071316biological_processcellular response to nicotine
D1904724cellular_componenttertiary granule lumen
D1990000biological_processamyloid fibril formation
D1990712cellular_componentHFE-transferrin receptor complex
D2000774biological_processpositive regulation of cellular senescence
D2000978biological_processnegative regulation of forebrain neuron differentiation
I0000139cellular_componentGolgi membrane
I0002376biological_processimmune system process
I0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
I0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
I0002502biological_processpeptide antigen assembly with MHC class I protein complex
I0002503biological_processpeptide antigen assembly with MHC class II protein complex
I0002715biological_processregulation of natural killer cell mediated immunity
I0002726biological_processpositive regulation of T cell cytokine production
I0005198molecular_functionstructural molecule activity
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0005765cellular_componentlysosomal membrane
I0005783cellular_componentendoplasmic reticulum
I0005788cellular_componentendoplasmic reticulum lumen
I0005794cellular_componentGolgi apparatus
I0005886cellular_componentplasma membrane
I0005925cellular_componentfocal adhesion
I0006879biological_processintracellular iron ion homeostasis
I0007608biological_processsensory perception of smell
I0007611biological_processlearning or memory
I0009897cellular_componentexternal side of plasma membrane
I0009986cellular_componentcell surface
I0010038biological_processresponse to metal ion
I0012507cellular_componentER to Golgi transport vesicle membrane
I0016020cellular_componentmembrane
I0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
I0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
I0023026molecular_functionMHC class II protein complex binding
I0030670cellular_componentphagocytic vesicle membrane
I0031901cellular_componentearly endosome membrane
I0031902cellular_componentlate endosome membrane
I0031905cellular_componentearly endosome lumen
I0033572biological_processtransferrin transport
I0034756biological_processregulation of iron ion transport
I0034757biological_processnegative regulation of iron ion transport
I0035580cellular_componentspecific granule lumen
I0042605molecular_functionpeptide antigen binding
I0042612cellular_componentMHC class I protein complex
I0042613cellular_componentMHC class II protein complex
I0042802molecular_functionidentical protein binding
I0042803molecular_functionprotein homodimerization activity
I0042824cellular_componentMHC class I peptide loading complex
I0048260biological_processpositive regulation of receptor-mediated endocytosis
I0048261biological_processnegative regulation of receptor-mediated endocytosis
I0050680biological_processnegative regulation of epithelial cell proliferation
I0050768biological_processnegative regulation of neurogenesis
I0050778biological_processpositive regulation of immune response
I0050870biological_processpositive regulation of T cell activation
I0051289biological_processprotein homotetramerization
I0055038cellular_componentrecycling endosome membrane
I0070062cellular_componentextracellular exosome
I0071281biological_processcellular response to iron ion
I0071316biological_processcellular response to nicotine
I1904724cellular_componenttertiary granule lumen
I1990000biological_processamyloid fibril formation
I1990712cellular_componentHFE-transferrin receptor complex
I2000774biological_processpositive regulation of cellular senescence
I2000978biological_processnegative regulation of forebrain neuron differentiation
N0000139cellular_componentGolgi membrane
N0002376biological_processimmune system process
N0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
N0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
N0002502biological_processpeptide antigen assembly with MHC class I protein complex
N0002503biological_processpeptide antigen assembly with MHC class II protein complex
N0002715biological_processregulation of natural killer cell mediated immunity
N0002726biological_processpositive regulation of T cell cytokine production
N0005198molecular_functionstructural molecule activity
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005615cellular_componentextracellular space
N0005765cellular_componentlysosomal membrane
N0005783cellular_componentendoplasmic reticulum
N0005788cellular_componentendoplasmic reticulum lumen
N0005794cellular_componentGolgi apparatus
N0005886cellular_componentplasma membrane
N0005925cellular_componentfocal adhesion
N0006879biological_processintracellular iron ion homeostasis
N0007608biological_processsensory perception of smell
N0007611biological_processlearning or memory
N0009897cellular_componentexternal side of plasma membrane
N0009986cellular_componentcell surface
N0010038biological_processresponse to metal ion
N0012507cellular_componentER to Golgi transport vesicle membrane
N0016020cellular_componentmembrane
N0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
N0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
N0023026molecular_functionMHC class II protein complex binding
N0030670cellular_componentphagocytic vesicle membrane
N0031901cellular_componentearly endosome membrane
N0031902cellular_componentlate endosome membrane
N0031905cellular_componentearly endosome lumen
N0033572biological_processtransferrin transport
N0034756biological_processregulation of iron ion transport
N0034757biological_processnegative regulation of iron ion transport
N0035580cellular_componentspecific granule lumen
N0042605molecular_functionpeptide antigen binding
N0042612cellular_componentMHC class I protein complex
N0042613cellular_componentMHC class II protein complex
N0042802molecular_functionidentical protein binding
N0042803molecular_functionprotein homodimerization activity
N0042824cellular_componentMHC class I peptide loading complex
N0048260biological_processpositive regulation of receptor-mediated endocytosis
N0048261biological_processnegative regulation of receptor-mediated endocytosis
N0050680biological_processnegative regulation of epithelial cell proliferation
N0050768biological_processnegative regulation of neurogenesis
N0050778biological_processpositive regulation of immune response
N0050870biological_processpositive regulation of T cell activation
N0051289biological_processprotein homotetramerization
N0055038cellular_componentrecycling endosome membrane
N0070062cellular_componentextracellular exosome
N0071281biological_processcellular response to iron ion
N0071316biological_processcellular response to nicotine
N1904724cellular_componenttertiary granule lumen
N1990000biological_processamyloid fibril formation
N1990712cellular_componentHFE-transferrin receptor complex
N2000774biological_processpositive regulation of cellular senescence
N2000978biological_processnegative regulation of forebrain neuron differentiation
S0000139cellular_componentGolgi membrane
S0002376biological_processimmune system process
S0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
S0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
S0002502biological_processpeptide antigen assembly with MHC class I protein complex
S0002503biological_processpeptide antigen assembly with MHC class II protein complex
S0002715biological_processregulation of natural killer cell mediated immunity
S0002726biological_processpositive regulation of T cell cytokine production
S0005198molecular_functionstructural molecule activity
S0005515molecular_functionprotein binding
S0005576cellular_componentextracellular region
S0005615cellular_componentextracellular space
S0005765cellular_componentlysosomal membrane
S0005783cellular_componentendoplasmic reticulum
S0005788cellular_componentendoplasmic reticulum lumen
S0005794cellular_componentGolgi apparatus
S0005886cellular_componentplasma membrane
S0005925cellular_componentfocal adhesion
S0006879biological_processintracellular iron ion homeostasis
S0007608biological_processsensory perception of smell
S0007611biological_processlearning or memory
S0009897cellular_componentexternal side of plasma membrane
S0009986cellular_componentcell surface
S0010038biological_processresponse to metal ion
S0012507cellular_componentER to Golgi transport vesicle membrane
S0016020cellular_componentmembrane
S0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
S0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
S0023026molecular_functionMHC class II protein complex binding
S0030670cellular_componentphagocytic vesicle membrane
S0031901cellular_componentearly endosome membrane
S0031902cellular_componentlate endosome membrane
S0031905cellular_componentearly endosome lumen
S0033572biological_processtransferrin transport
S0034756biological_processregulation of iron ion transport
S0034757biological_processnegative regulation of iron ion transport
S0035580cellular_componentspecific granule lumen
S0042605molecular_functionpeptide antigen binding
S0042612cellular_componentMHC class I protein complex
S0042613cellular_componentMHC class II protein complex
S0042802molecular_functionidentical protein binding
S0042803molecular_functionprotein homodimerization activity
S0042824cellular_componentMHC class I peptide loading complex
S0048260biological_processpositive regulation of receptor-mediated endocytosis
S0048261biological_processnegative regulation of receptor-mediated endocytosis
S0050680biological_processnegative regulation of epithelial cell proliferation
S0050768biological_processnegative regulation of neurogenesis
S0050778biological_processpositive regulation of immune response
S0050870biological_processpositive regulation of T cell activation
S0051289biological_processprotein homotetramerization
S0055038cellular_componentrecycling endosome membrane
S0070062cellular_componentextracellular exosome
S0071281biological_processcellular response to iron ion
S0071316biological_processcellular response to nicotine
S1904724cellular_componenttertiary granule lumen
S1990000biological_processamyloid fibril formation
S1990712cellular_componentHFE-transferrin receptor complex
S2000774biological_processpositive regulation of cellular senescence
S2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH
ChainResidueDetails
DTYR78-HIS84
CTYR257-HIS263
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues267
DetailsDomain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues7
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues364
DetailsRegion: {"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues24
DetailsMotif: {"description":"Bw6 motif","evidences":[{"source":"PubMed","id":"25480565","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25808313","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues438
DetailsDomain: {"description":"Ig-like C1-type"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues91
DetailsRegion: {"description":"Alpha-3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues89
DetailsRegion: {"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsModified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues24
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33264373","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ACS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ACT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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