9VOS
Cryo-EM Structure of GPR158 in Complex with RGS7-Gbeta5 and Nanobody Nb20
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. IVSSsqDgKVIVWDS |
| Chain | Residue | Details |
| D | ILE78-SER92 | |
| D | ILE168-VAL182 | |
| D | LEU298-VAL312 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 94 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 72 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34793198","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34815401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SHF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36996198","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 10 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8C419","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
