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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9VMM

human CTPS1 with 2CTP and DON

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0003883molecular_functionCTP synthase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006139biological_processnucleobase-containing compound metabolic process
A0006241biological_processCTP biosynthetic process
A0009410biological_processresponse to xenobiotic stimulus
A0016020cellular_componentmembrane
A0019856biological_processpyrimidine nucleobase biosynthetic process
A0032480biological_processnegative regulation of type I interferon production
A0042098biological_processT cell proliferation
A0042100biological_processB cell proliferation
A0042802molecular_functionidentical protein binding
A0044210biological_process'de novo' CTP biosynthetic process
A0090407biological_processorganophosphate biosynthetic process
A0097268cellular_componentcytoophidium
A0140861biological_processDNA repair-dependent chromatin remodeling
A0160260molecular_functionprotein asparagine deamidase activity
A0160264molecular_functionhistone H1N76/N77 asparagine deamidase activity
A1902340biological_processnegative regulation of chromosome condensation
B0000785cellular_componentchromatin
B0003883molecular_functionCTP synthase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006139biological_processnucleobase-containing compound metabolic process
B0006241biological_processCTP biosynthetic process
B0009410biological_processresponse to xenobiotic stimulus
B0016020cellular_componentmembrane
B0019856biological_processpyrimidine nucleobase biosynthetic process
B0032480biological_processnegative regulation of type I interferon production
B0042098biological_processT cell proliferation
B0042100biological_processB cell proliferation
B0042802molecular_functionidentical protein binding
B0044210biological_process'de novo' CTP biosynthetic process
B0090407biological_processorganophosphate biosynthetic process
B0097268cellular_componentcytoophidium
B0140861biological_processDNA repair-dependent chromatin remodeling
B0160260molecular_functionprotein asparagine deamidase activity
B0160264molecular_functionhistone H1N76/N77 asparagine deamidase activity
B1902340biological_processnegative regulation of chromosome condensation
C0000785cellular_componentchromatin
C0003883molecular_functionCTP synthase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006139biological_processnucleobase-containing compound metabolic process
C0006241biological_processCTP biosynthetic process
C0009410biological_processresponse to xenobiotic stimulus
C0016020cellular_componentmembrane
C0019856biological_processpyrimidine nucleobase biosynthetic process
C0032480biological_processnegative regulation of type I interferon production
C0042098biological_processT cell proliferation
C0042100biological_processB cell proliferation
C0042802molecular_functionidentical protein binding
C0044210biological_process'de novo' CTP biosynthetic process
C0090407biological_processorganophosphate biosynthetic process
C0097268cellular_componentcytoophidium
C0140861biological_processDNA repair-dependent chromatin remodeling
C0160260molecular_functionprotein asparagine deamidase activity
C0160264molecular_functionhistone H1N76/N77 asparagine deamidase activity
C1902340biological_processnegative regulation of chromosome condensation
D0000785cellular_componentchromatin
D0003883molecular_functionCTP synthase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005694cellular_componentchromosome
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006139biological_processnucleobase-containing compound metabolic process
D0006241biological_processCTP biosynthetic process
D0009410biological_processresponse to xenobiotic stimulus
D0016020cellular_componentmembrane
D0019856biological_processpyrimidine nucleobase biosynthetic process
D0032480biological_processnegative regulation of type I interferon production
D0042098biological_processT cell proliferation
D0042100biological_processB cell proliferation
D0042802molecular_functionidentical protein binding
D0044210biological_process'de novo' CTP biosynthetic process
D0090407biological_processorganophosphate biosynthetic process
D0097268cellular_componentcytoophidium
D0140861biological_processDNA repair-dependent chromatin remodeling
D0160260molecular_functionprotein asparagine deamidase activity
D0160264molecular_functionhistone H1N76/N77 asparagine deamidase activity
D1902340biological_processnegative regulation of chromosome condensation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsActive site: {"description":"For GATase and protein-asparagine deamidase activities","evidences":[{"source":"PubMed","id":"40240600","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28459447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U03","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28459447","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MGZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MH0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28459447","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MGZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MGZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine; by PKA and PKC","evidences":[{"source":"PubMed","id":"17189248","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17463002","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"17463002","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2026-04-01

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