Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9VED

The cryo-EM structure of mouse Piezo1-MDFI complex

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YQCVAAH

Chain	Residue	Details
A	TYR1680-HIS1686

site_id	PS00652
Number of Residues	39
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Clfce..Fltlcnilld.CatCgs.Cssedsclc...Ccccg..SGEC

Chain	Residue	Details
F	CYS171-CYS209

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=17","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	51
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	39
Details	Transmembrane: {"description":"Helical; Name=18","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	672
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=21","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=22","evidences":[{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=23","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=24","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	78
Details	Transmembrane: {"description":"Helical; Name=25","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=26","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=27","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=28","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	129
Details	Transmembrane: {"description":"Helical; Name=29","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=30","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=31","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=32","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=33","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=34","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=35","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=36","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=37","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=38","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	93
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19144319","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)