9VEC

structure of human KCNQ1-KCNE1-CaM complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000922	cellular_component	spindle pole
B	0002027	biological_process	regulation of heart rate
B	0005246	molecular_function	calcium channel regulator activity
B	0005509	molecular_function	calcium ion binding
B	0005513	biological_process	detection of calcium ion
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005876	cellular_component	spindle microtubule
B	0005886	cellular_component	plasma membrane
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0010856	molecular_function	adenylate cyclase activator activity
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0016020	cellular_component	membrane
B	0016240	biological_process	autophagosome membrane docking
B	0019855	molecular_function	calcium channel inhibitor activity
B	0019901	molecular_function	protein kinase binding
B	0021762	biological_process	substantia nigra development
B	0030017	cellular_component	sarcomere
B	0031432	molecular_function	titin binding
B	0031514	cellular_component	motile cilium
B	0031982	cellular_component	vesicle
B	0032465	biological_process	regulation of cytokinesis
B	0032991	cellular_component	protein-containing complex
B	0034704	cellular_component	calcium channel complex
B	0035458	biological_process	cellular response to interferon-beta
B	0043209	cellular_component	myelin sheath
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0044305	cellular_component	calyx of Held
B	0044325	molecular_function	transmembrane transporter binding
B	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0051592	biological_process	response to calcium ion
B	0055117	biological_process	regulation of cardiac muscle contraction
B	0060291	biological_process	long-term synaptic potentiation
B	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
B	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
B	0071346	biological_process	cellular response to type II interferon
B	0072542	molecular_function	protein phosphatase activator activity
B	0097225	cellular_component	sperm midpiece
B	0097720	biological_process	calcineurin-mediated signaling
B	0098901	biological_process	regulation of cardiac muscle cell action potential
B	0099523	cellular_component	presynaptic cytosol
B	0140056	biological_process	organelle localization by membrane tethering
B	0140238	biological_process	presynaptic endocytosis
B	0141110	molecular_function	transporter inhibitor activity
B	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
B	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
B	1902494	cellular_component	catalytic complex
B	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
B	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005251	molecular_function	delayed rectifier potassium channel activity
C	0005267	molecular_function	potassium channel activity
C	0005515	molecular_function	protein binding
C	0005764	cellular_component	lysosome
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0007605	biological_process	sensory perception of sound
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0009986	cellular_component	cell surface
C	0015459	molecular_function	potassium channel regulator activity
C	0016324	cellular_component	apical plasma membrane
C	0021750	biological_process	vestibular nucleus development
C	0030018	cellular_component	Z disc
C	0031433	molecular_function	telethonin binding
C	0033363	biological_process	secretory granule organization
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0042391	biological_process	regulation of membrane potential
C	0043266	biological_process	regulation of potassium ion transport
C	0044325	molecular_function	transmembrane transporter binding
C	0045121	cellular_component	membrane raft
C	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
C	0071320	biological_process	cellular response to cAMP
C	0071805	biological_process	potassium ion transmembrane transport
C	0086002	biological_process	cardiac muscle cell action potential involved in contraction
C	0086003	biological_process	cardiac muscle cell contraction
C	0086005	biological_process	ventricular cardiac muscle cell action potential
C	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
C	0086009	biological_process	membrane repolarization
C	0086011	biological_process	membrane repolarization during action potential
C	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
C	0086091	biological_process	regulation of heart rate by cardiac conduction
C	0090315	biological_process	negative regulation of protein targeting to membrane
C	0097623	biological_process	potassium ion export across plasma membrane
C	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
C	1901379	biological_process	regulation of potassium ion transmembrane transport
C	1901381	biological_process	positive regulation of potassium ion transmembrane transport
C	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
C	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
E	0000922	cellular_component	spindle pole
E	0002027	biological_process	regulation of heart rate
E	0005246	molecular_function	calcium channel regulator activity
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005876	cellular_component	spindle microtubule
E	0005886	cellular_component	plasma membrane
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0010856	molecular_function	adenylate cyclase activator activity
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0016240	biological_process	autophagosome membrane docking
E	0019855	molecular_function	calcium channel inhibitor activity
E	0019901	molecular_function	protein kinase binding
E	0021762	biological_process	substantia nigra development
E	0030017	cellular_component	sarcomere
E	0031432	molecular_function	titin binding
E	0031514	cellular_component	motile cilium
E	0031982	cellular_component	vesicle
E	0032465	biological_process	regulation of cytokinesis
E	0032991	cellular_component	protein-containing complex
E	0034704	cellular_component	calcium channel complex
E	0035458	biological_process	cellular response to interferon-beta
E	0043209	cellular_component	myelin sheath
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0044305	cellular_component	calyx of Held
E	0044325	molecular_function	transmembrane transporter binding
E	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0051592	biological_process	response to calcium ion
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060291	biological_process	long-term synaptic potentiation
E	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
E	0071346	biological_process	cellular response to type II interferon
E	0072542	molecular_function	protein phosphatase activator activity
E	0097225	cellular_component	sperm midpiece
E	0097720	biological_process	calcineurin-mediated signaling
E	0098901	biological_process	regulation of cardiac muscle cell action potential
E	0099523	cellular_component	presynaptic cytosol
E	0140056	biological_process	organelle localization by membrane tethering
E	0140238	biological_process	presynaptic endocytosis
E	0141110	molecular_function	transporter inhibitor activity
E	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
E	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
E	1902494	cellular_component	catalytic complex
E	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
E	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
F	0005249	molecular_function	voltage-gated potassium channel activity
F	0005251	molecular_function	delayed rectifier potassium channel activity
F	0005267	molecular_function	potassium channel activity
F	0005515	molecular_function	protein binding
F	0005764	cellular_component	lysosome
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006813	biological_process	potassium ion transport
F	0007605	biological_process	sensory perception of sound
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0009986	cellular_component	cell surface
F	0015459	molecular_function	potassium channel regulator activity
F	0016324	cellular_component	apical plasma membrane
F	0021750	biological_process	vestibular nucleus development
F	0030018	cellular_component	Z disc
F	0031433	molecular_function	telethonin binding
F	0033363	biological_process	secretory granule organization
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034702	cellular_component	monoatomic ion channel complex
F	0042391	biological_process	regulation of membrane potential
F	0043266	biological_process	regulation of potassium ion transport
F	0044325	molecular_function	transmembrane transporter binding
F	0045121	cellular_component	membrane raft
F	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
F	0071320	biological_process	cellular response to cAMP
F	0071805	biological_process	potassium ion transmembrane transport
F	0086002	biological_process	cardiac muscle cell action potential involved in contraction
F	0086003	biological_process	cardiac muscle cell contraction
F	0086005	biological_process	ventricular cardiac muscle cell action potential
F	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
F	0086009	biological_process	membrane repolarization
F	0086011	biological_process	membrane repolarization during action potential
F	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
F	0086091	biological_process	regulation of heart rate by cardiac conduction
F	0090315	biological_process	negative regulation of protein targeting to membrane
F	0097623	biological_process	potassium ion export across plasma membrane
F	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
F	1901379	biological_process	regulation of potassium ion transmembrane transport
F	1901381	biological_process	positive regulation of potassium ion transmembrane transport
F	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
F	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
H	0000922	cellular_component	spindle pole
H	0002027	biological_process	regulation of heart rate
H	0005246	molecular_function	calcium channel regulator activity
H	0005509	molecular_function	calcium ion binding
H	0005513	biological_process	detection of calcium ion
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0005876	cellular_component	spindle microtubule
H	0005886	cellular_component	plasma membrane
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0010856	molecular_function	adenylate cyclase activator activity
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016240	biological_process	autophagosome membrane docking
H	0019855	molecular_function	calcium channel inhibitor activity
H	0019901	molecular_function	protein kinase binding
H	0021762	biological_process	substantia nigra development
H	0030017	cellular_component	sarcomere
H	0031432	molecular_function	titin binding
H	0031514	cellular_component	motile cilium
H	0031982	cellular_component	vesicle
H	0032465	biological_process	regulation of cytokinesis
H	0032991	cellular_component	protein-containing complex
H	0034704	cellular_component	calcium channel complex
H	0035458	biological_process	cellular response to interferon-beta
H	0043209	cellular_component	myelin sheath
H	0043539	molecular_function	protein serine/threonine kinase activator activity
H	0044305	cellular_component	calyx of Held
H	0044325	molecular_function	transmembrane transporter binding
H	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0051592	biological_process	response to calcium ion
H	0055117	biological_process	regulation of cardiac muscle contraction
H	0060291	biological_process	long-term synaptic potentiation
H	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
H	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
H	0071346	biological_process	cellular response to type II interferon
H	0072542	molecular_function	protein phosphatase activator activity
H	0097225	cellular_component	sperm midpiece
H	0097720	biological_process	calcineurin-mediated signaling
H	0098901	biological_process	regulation of cardiac muscle cell action potential
H	0099523	cellular_component	presynaptic cytosol
H	0140056	biological_process	organelle localization by membrane tethering
H	0140238	biological_process	presynaptic endocytosis
H	0141110	molecular_function	transporter inhibitor activity
H	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
H	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
H	1902494	cellular_component	catalytic complex
H	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
H	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
I	0005249	molecular_function	voltage-gated potassium channel activity
I	0005251	molecular_function	delayed rectifier potassium channel activity
I	0005267	molecular_function	potassium channel activity
I	0005515	molecular_function	protein binding
I	0005764	cellular_component	lysosome
I	0005886	cellular_component	plasma membrane
I	0006811	biological_process	monoatomic ion transport
I	0006813	biological_process	potassium ion transport
I	0007605	biological_process	sensory perception of sound
I	0008076	cellular_component	voltage-gated potassium channel complex
I	0009986	cellular_component	cell surface
I	0015459	molecular_function	potassium channel regulator activity
I	0016324	cellular_component	apical plasma membrane
I	0021750	biological_process	vestibular nucleus development
I	0030018	cellular_component	Z disc
I	0031433	molecular_function	telethonin binding
I	0033363	biological_process	secretory granule organization
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0034702	cellular_component	monoatomic ion channel complex
I	0042391	biological_process	regulation of membrane potential
I	0043266	biological_process	regulation of potassium ion transport
I	0044325	molecular_function	transmembrane transporter binding
I	0045121	cellular_component	membrane raft
I	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
I	0071320	biological_process	cellular response to cAMP
I	0071805	biological_process	potassium ion transmembrane transport
I	0086002	biological_process	cardiac muscle cell action potential involved in contraction
I	0086003	biological_process	cardiac muscle cell contraction
I	0086005	biological_process	ventricular cardiac muscle cell action potential
I	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
I	0086009	biological_process	membrane repolarization
I	0086011	biological_process	membrane repolarization during action potential
I	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
I	0086091	biological_process	regulation of heart rate by cardiac conduction
I	0090315	biological_process	negative regulation of protein targeting to membrane
I	0097623	biological_process	potassium ion export across plasma membrane
I	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
I	1901379	biological_process	regulation of potassium ion transmembrane transport
I	1901381	biological_process	positive regulation of potassium ion transmembrane transport
I	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
I	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
K	0000922	cellular_component	spindle pole
K	0002027	biological_process	regulation of heart rate
K	0005246	molecular_function	calcium channel regulator activity
K	0005509	molecular_function	calcium ion binding
K	0005513	biological_process	detection of calcium ion
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0005876	cellular_component	spindle microtubule
K	0005886	cellular_component	plasma membrane
K	0007186	biological_process	G protein-coupled receptor signaling pathway
K	0008076	cellular_component	voltage-gated potassium channel complex
K	0010856	molecular_function	adenylate cyclase activator activity
K	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K	0016020	cellular_component	membrane
K	0016240	biological_process	autophagosome membrane docking
K	0019855	molecular_function	calcium channel inhibitor activity
K	0019901	molecular_function	protein kinase binding
K	0021762	biological_process	substantia nigra development
K	0030017	cellular_component	sarcomere
K	0031432	molecular_function	titin binding
K	0031514	cellular_component	motile cilium
K	0031982	cellular_component	vesicle
K	0032465	biological_process	regulation of cytokinesis
K	0032991	cellular_component	protein-containing complex
K	0034704	cellular_component	calcium channel complex
K	0035458	biological_process	cellular response to interferon-beta
K	0043209	cellular_component	myelin sheath
K	0043539	molecular_function	protein serine/threonine kinase activator activity
K	0044305	cellular_component	calyx of Held
K	0044325	molecular_function	transmembrane transporter binding
K	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
K	0046872	molecular_function	metal ion binding
K	0048306	molecular_function	calcium-dependent protein binding
K	0051592	biological_process	response to calcium ion
K	0055117	biological_process	regulation of cardiac muscle contraction
K	0060291	biological_process	long-term synaptic potentiation
K	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
K	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
K	0071346	biological_process	cellular response to type II interferon
K	0072542	molecular_function	protein phosphatase activator activity
K	0097225	cellular_component	sperm midpiece
K	0097720	biological_process	calcineurin-mediated signaling
K	0098901	biological_process	regulation of cardiac muscle cell action potential
K	0099523	cellular_component	presynaptic cytosol
K	0140056	biological_process	organelle localization by membrane tethering
K	0140238	biological_process	presynaptic endocytosis
K	0141110	molecular_function	transporter inhibitor activity
K	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
K	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
K	1902494	cellular_component	catalytic complex
K	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
K	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
L	0005249	molecular_function	voltage-gated potassium channel activity
L	0005251	molecular_function	delayed rectifier potassium channel activity
L	0005267	molecular_function	potassium channel activity
L	0005515	molecular_function	protein binding
L	0005764	cellular_component	lysosome
L	0005886	cellular_component	plasma membrane
L	0006811	biological_process	monoatomic ion transport
L	0006813	biological_process	potassium ion transport
L	0007605	biological_process	sensory perception of sound
L	0008076	cellular_component	voltage-gated potassium channel complex
L	0009986	cellular_component	cell surface
L	0015459	molecular_function	potassium channel regulator activity
L	0016324	cellular_component	apical plasma membrane
L	0021750	biological_process	vestibular nucleus development
L	0030018	cellular_component	Z disc
L	0031433	molecular_function	telethonin binding
L	0033363	biological_process	secretory granule organization
L	0034220	biological_process	monoatomic ion transmembrane transport
L	0034702	cellular_component	monoatomic ion channel complex
L	0042391	biological_process	regulation of membrane potential
L	0043266	biological_process	regulation of potassium ion transport
L	0044325	molecular_function	transmembrane transporter binding
L	0045121	cellular_component	membrane raft
L	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
L	0071320	biological_process	cellular response to cAMP
L	0071805	biological_process	potassium ion transmembrane transport
L	0086002	biological_process	cardiac muscle cell action potential involved in contraction
L	0086003	biological_process	cardiac muscle cell contraction
L	0086005	biological_process	ventricular cardiac muscle cell action potential
L	0086008	molecular_function	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
L	0086009	biological_process	membrane repolarization
L	0086011	biological_process	membrane repolarization during action potential
L	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
L	0086091	biological_process	regulation of heart rate by cardiac conduction
L	0090315	biological_process	negative regulation of protein targeting to membrane
L	0097623	biological_process	potassium ion export across plasma membrane
L	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
L	1901379	biological_process	regulation of potassium ion transmembrane transport
L	1901381	biological_process	positive regulation of potassium ion transmembrane transport
L	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
L	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
K	ASP21-LEU33
K	ASP57-PHE69
K	ASP94-LEU106
K	ASP130-PHE142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	140
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	128
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	288
Details	Region: {"description":"Necessary and sufficient for interaction with PCP4","evidences":[{"source":"PubMed","id":"27876793","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25441029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V0C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29724949","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CNO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"UniProtKB","id":"P0DP29","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	104
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	128
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	80
Details	Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	32
Details	Region: {"description":"Interaction with KCNE3","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	48
Details	Region: {"description":"Interaction with CALM","evidences":[{"source":"PubMed","id":"25441029","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	56
Details	Region: {"description":"Interaction with CALM; calcium-dependent","evidences":[{"source":"PubMed","id":"25441029","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---