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9V10

Cryo-EM structure of the 48-nm repeat doublet microtubule from mouse sperm

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
00003674molecular_functionmolecular_function
00005737cellular_componentcytoplasm
00005879cellular_componentaxonemal microtubule
00005886cellular_componentplasma membrane
00005930cellular_componentaxoneme
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00030317biological_processflagellated sperm motility
00036126cellular_componentsperm flagellum
00160111cellular_componentaxonemal A tubule inner sheath
10005575cellular_componentcellular_component
10005737cellular_componentcytoplasm
10005879cellular_componentaxonemal microtubule
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10032091biological_processnegative regulation of protein binding
10036126cellular_componentsperm flagellum
10061891molecular_functioncalcium ion sensor activity
10070884biological_processregulation of calcineurin-NFAT signaling cascade
10160111cellular_componentaxonemal A tubule inner sheath
12001256biological_processregulation of store-operated calcium entry
20005575cellular_componentcellular_component
20005737cellular_componentcytoplasm
20005879cellular_componentaxonemal microtubule
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20032091biological_processnegative regulation of protein binding
20036126cellular_componentsperm flagellum
20061891molecular_functioncalcium ion sensor activity
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20160111cellular_componentaxonemal A tubule inner sheath
22001256biological_processregulation of store-operated calcium entry
30000922cellular_componentspindle pole
30002177cellular_componentmanchette
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30003674molecular_functionmolecular_function
30005515molecular_functionprotein binding
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30030317biological_processflagellated sperm motility
30034451cellular_componentcentriolar satellite
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30036126cellular_componentsperm flagellum
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30090660biological_processcerebrospinal fluid circulation
30097728cellular_component9+0 motile cilium
30097729cellular_component9+2 motile cilium
30099513cellular_componentpolymeric cytoskeletal fiber
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40030317biological_processflagellated sperm motility
40034451cellular_componentcentriolar satellite
40035869cellular_componentciliary transition zone
40036126cellular_componentsperm flagellum
40060271biological_processcilium assembly
40060287biological_processepithelial cilium movement involved in determination of left/right asymmetry
40090660biological_processcerebrospinal fluid circulation
40097728cellular_component9+0 motile cilium
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40120229biological_processprotein localization to motile cilium
40120316biological_processsperm flagellum assembly
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41905198biological_processmanchette assembly
50000931cellular_componentgamma-tubulin ring complex
50003351biological_processepithelial cilium movement involved in extracellular fluid movement
50004672molecular_functionprotein kinase activity
50004674molecular_functionprotein serine/threonine kinase activity
50005576cellular_componentextracellular region
50005634cellular_componentnucleus
50005654cellular_componentnucleoplasm
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50005813cellular_componentcentrosome
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50005879cellular_componentaxonemal microtubule
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50007368biological_processdetermination of left/right symmetry
50007420biological_processbrain development
50008296molecular_function3'-5'-DNA exonuclease activity
50010968biological_processregulation of microtubule nucleation
50030317biological_processflagellated sperm motility
50036064cellular_componentciliary basal body
50036126cellular_componentsperm flagellum
50042073biological_processintraciliary transport
50043113biological_processreceptor clustering
50060271biological_processcilium assembly
50060972biological_processleft/right pattern formation
50106310molecular_functionprotein serine kinase activity
50160111cellular_componentaxonemal A tubule inner sheath
51990830biological_processcellular response to leukemia inhibitory factor
60000931cellular_componentgamma-tubulin ring complex
60003351biological_processepithelial cilium movement involved in extracellular fluid movement
60004672molecular_functionprotein kinase activity
60004674molecular_functionprotein serine/threonine kinase activity
60005576cellular_componentextracellular region
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
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60005879cellular_componentaxonemal microtubule
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60005930cellular_componentaxoneme
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60007368biological_processdetermination of left/right symmetry
60007420biological_processbrain development
60008296molecular_function3'-5'-DNA exonuclease activity
60010968biological_processregulation of microtubule nucleation
60030317biological_processflagellated sperm motility
60036064cellular_componentciliary basal body
60036126cellular_componentsperm flagellum
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60106310molecular_functionprotein serine kinase activity
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70003674molecular_functionmolecular_function
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70030317biological_processflagellated sperm motility
70036126cellular_componentsperm flagellum
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80003674molecular_functionmolecular_function
80005575cellular_componentcellular_component
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a0005879cellular_componentaxonemal microtubule
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a0036126cellular_componentsperm flagellum
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a0097225cellular_componentsperm midpiece
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a0097728cellular_component9+0 motile cilium
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a0099513cellular_componentpolymeric cytoskeletal fiber
a0160112cellular_componentaxonemal B tubule inner sheath
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A0030317biological_processflagellated sperm motility
A0036126cellular_componentsperm flagellum
A0160111cellular_componentaxonemal A tubule inner sheath
A00005879cellular_componentaxonemal microtubule
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A00030317biological_processflagellated sperm motility
A00036126cellular_componentsperm flagellum
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A00160111cellular_componentaxonemal A tubule inner sheath
a10003674molecular_functionmolecular_function
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a10160111cellular_componentaxonemal A tubule inner sheath
A10005879cellular_componentaxonemal microtubule
A10005930cellular_componentaxoneme
A10015630cellular_componentmicrotubule cytoskeleton
A10030317biological_processflagellated sperm motility
A10036126cellular_componentsperm flagellum
A10060271biological_processcilium assembly
A10060294biological_processcilium movement involved in cell motility
A10160111cellular_componentaxonemal A tubule inner sheath
a20003674molecular_functionmolecular_function
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a20008150biological_processbiological_process
a20030317biological_processflagellated sperm motility
a20036126cellular_componentsperm flagellum
a20160111cellular_componentaxonemal A tubule inner sheath
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A20015630cellular_componentmicrotubule cytoskeleton
A20030317biological_processflagellated sperm motility
A20036126cellular_componentsperm flagellum
A20060271biological_processcilium assembly
A20060294biological_processcilium movement involved in cell motility
A20160111cellular_componentaxonemal A tubule inner sheath
a30003674molecular_functionmolecular_function
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a30030317biological_processflagellated sperm motility
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A30030317biological_processflagellated sperm motility
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A50030317biological_processflagellated sperm motility
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A50060294biological_processcilium movement involved in cell motility
A50160111cellular_componentaxonemal A tubule inner sheath
a60005515molecular_functionprotein binding
a60005576cellular_componentextracellular region
a60005879cellular_componentaxonemal microtubule
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a60030317biological_processflagellated sperm motility
a60031514cellular_componentmotile cilium
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a60060287biological_processepithelial cilium movement involved in determination of left/right asymmetry
a60060296biological_processregulation of cilium beat frequency involved in ciliary motility
a60061966biological_processestablishment of left/right asymmetry
a60090660biological_processcerebrospinal fluid circulation
a60097225cellular_componentsperm midpiece
a60097228cellular_componentsperm principal piece
a60097229cellular_componentsperm end piece
a60097728cellular_component9+0 motile cilium
a60097729cellular_component9+2 motile cilium
a60099513cellular_componentpolymeric cytoskeletal fiber
a60160112cellular_componentaxonemal B tubule inner sheath
Aa0003674molecular_functionmolecular_function
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Aa0007288biological_processsperm axoneme assembly
AA0000226biological_processmicrotubule cytoskeleton organization
AA0000278biological_processmitotic cell cycle
AA0003924molecular_functionGTPase activity
AA0005200molecular_functionstructural constituent of cytoskeleton
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AA0030317biological_processflagellated sperm motility
AA0036126cellular_componentsperm flagellum
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AB0000278biological_processmitotic cell cycle
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AB0005525molecular_functionGTP binding
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AB0005856cellular_componentcytoskeleton
AB0005874cellular_componentmicrotubule
AB0005879cellular_componentaxonemal microtubule
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AB0015630cellular_componentmicrotubule cytoskeleton
AB0030317biological_processflagellated sperm motility
AB0036126cellular_componentsperm flagellum
AB0043209cellular_componentmyelin sheath
AB0045171cellular_componentintercellular bridge
AB0045298cellular_componenttubulin complex
AB0072686cellular_componentmitotic spindle
Ac0003674molecular_functionmolecular_function
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Ac0007288biological_processsperm axoneme assembly
AC0000226biological_processmicrotubule cytoskeleton organization
AC0000278biological_processmitotic cell cycle
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AC0005525molecular_functionGTP binding
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AC0005856cellular_componentcytoskeleton
AC0005874cellular_componentmicrotubule
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AC0015630cellular_componentmicrotubule cytoskeleton
AC0030317biological_processflagellated sperm motility
AC0036126cellular_componentsperm flagellum
AD0000226biological_processmicrotubule cytoskeleton organization
AD0000278biological_processmitotic cell cycle
AD0003725molecular_functiondouble-stranded RNA binding
AD0005200molecular_functionstructural constituent of cytoskeleton
AD0005525molecular_functionGTP binding
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AD0005856cellular_componentcytoskeleton
AD0005874cellular_componentmicrotubule
AD0005879cellular_componentaxonemal microtubule
AD0007017biological_processmicrotubule-based process
AD0015630cellular_componentmicrotubule cytoskeleton
AD0030317biological_processflagellated sperm motility
AD0036126cellular_componentsperm flagellum
AD0043209cellular_componentmyelin sheath
AD0045171cellular_componentintercellular bridge
AD0045298cellular_componenttubulin complex
AD0072686cellular_componentmitotic spindle
AE0000226biological_processmicrotubule cytoskeleton organization
AE0000278biological_processmitotic cell cycle
AE0003924molecular_functionGTPase activity
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AE0005525molecular_functionGTP binding
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AE0030317biological_processflagellated sperm motility
AE0036126cellular_componentsperm flagellum
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AF0005879cellular_componentaxonemal microtubule
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AF0030317biological_processflagellated sperm motility
AF0036126cellular_componentsperm flagellum
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AH0030317biological_processflagellated sperm motility
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B00005879cellular_componentaxonemal microtubule
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b10036126cellular_componentsperm flagellum
b10097649cellular_componentA axonemal microtubule
b10160110cellular_componentaxonemal microtubule doublet inner sheath
b10160112cellular_componentaxonemal B tubule inner sheath
B10005814cellular_componentcentriole
B10005815cellular_componentmicrotubule organizing center
B10005879cellular_componentaxonemal microtubule
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B10097225cellular_componentsperm midpiece
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B10120212cellular_componentsperm head-tail coupling apparatus
B10160111cellular_componentaxonemal A tubule inner sheath
b20003674molecular_functionmolecular_function
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b20030317biological_processflagellated sperm motility
b20036126cellular_componentsperm flagellum
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g0097225cellular_componentsperm midpiece
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YC0048487molecular_functionbeta-tubulin binding
YC0051087molecular_functionprotein-folding chaperone binding
YC0051879molecular_functionHsp90 protein binding
YC0097225cellular_componentsperm midpiece
YC0097228cellular_componentsperm principal piece
YC0097229cellular_componentsperm end piece
YC0160112cellular_componentaxonemal B tubule inner sheath
YD0001664molecular_functionG protein-coupled receptor binding
YD0002177cellular_componentmanchette
YD0003779molecular_functionactin binding
YD0005515molecular_functionprotein binding
YD0005739cellular_componentmitochondrion
YD0005829cellular_componentcytosol
YD0005879cellular_componentaxonemal microtubule
YD0005929cellular_componentcilium
YD0005930cellular_componentaxoneme
YD0007286biological_processspermatid development
YD0008104biological_processintracellular protein localization
YD0030317biological_processflagellated sperm motility
YD0030544molecular_functionHsp70 protein binding
YD0031072molecular_functionheat shock protein binding
YD0031625molecular_functionubiquitin protein ligase binding
YD0031982cellular_componentvesicle
YD0034620biological_processcellular response to unfolded protein
YD0036126cellular_componentsperm flagellum
YD0043005cellular_componentneuron projection
YD0043014molecular_functionalpha-tubulin binding
YD0044297cellular_componentcell body
YD0048487molecular_functionbeta-tubulin binding
YD0051087molecular_functionprotein-folding chaperone binding
YD0051879molecular_functionHsp90 protein binding
YD0097225cellular_componentsperm midpiece
YD0097228cellular_componentsperm principal piece
YD0097229cellular_componentsperm end piece
YD0160112cellular_componentaxonemal B tubule inner sheath
YE0001664molecular_functionG protein-coupled receptor binding
YE0002177cellular_componentmanchette
YE0003779molecular_functionactin binding
YE0005515molecular_functionprotein binding
YE0005739cellular_componentmitochondrion
YE0005829cellular_componentcytosol
YE0005879cellular_componentaxonemal microtubule
YE0005929cellular_componentcilium
YE0005930cellular_componentaxoneme
YE0007286biological_processspermatid development
YE0008104biological_processintracellular protein localization
YE0030317biological_processflagellated sperm motility
YE0030544molecular_functionHsp70 protein binding
YE0031072molecular_functionheat shock protein binding
YE0031625molecular_functionubiquitin protein ligase binding
YE0031982cellular_componentvesicle
YE0034620biological_processcellular response to unfolded protein
YE0036126cellular_componentsperm flagellum
YE0043005cellular_componentneuron projection
YE0043014molecular_functionalpha-tubulin binding
YE0044297cellular_componentcell body
YE0048487molecular_functionbeta-tubulin binding
YE0051087molecular_functionprotein-folding chaperone binding
YE0051879molecular_functionHsp90 protein binding
YE0097225cellular_componentsperm midpiece
YE0097228cellular_componentsperm principal piece
YE0097229cellular_componentsperm end piece
YE0160112cellular_componentaxonemal B tubule inner sheath
YF0001664molecular_functionG protein-coupled receptor binding
YF0002177cellular_componentmanchette
YF0003779molecular_functionactin binding
YF0005515molecular_functionprotein binding
YF0005739cellular_componentmitochondrion
YF0005829cellular_componentcytosol
YF0005879cellular_componentaxonemal microtubule
YF0005929cellular_componentcilium
YF0005930cellular_componentaxoneme
YF0007286biological_processspermatid development
YF0008104biological_processintracellular protein localization
YF0030317biological_processflagellated sperm motility
YF0030544molecular_functionHsp70 protein binding
YF0031072molecular_functionheat shock protein binding
YF0031625molecular_functionubiquitin protein ligase binding
YF0031982cellular_componentvesicle
YF0034620biological_processcellular response to unfolded protein
YF0036126cellular_componentsperm flagellum
YF0043005cellular_componentneuron projection
YF0043014molecular_functionalpha-tubulin binding
YF0044297cellular_componentcell body
YF0048487molecular_functionbeta-tubulin binding
YF0051087molecular_functionprotein-folding chaperone binding
YF0051879molecular_functionHsp90 protein binding
YF0097225cellular_componentsperm midpiece
YF0097228cellular_componentsperm principal piece
YF0097229cellular_componentsperm end piece
YF0160112cellular_componentaxonemal B tubule inner sheath
YG0001664molecular_functionG protein-coupled receptor binding
YG0002177cellular_componentmanchette
YG0003779molecular_functionactin binding
YG0005515molecular_functionprotein binding
YG0005739cellular_componentmitochondrion
YG0005829cellular_componentcytosol
YG0005879cellular_componentaxonemal microtubule
YG0005929cellular_componentcilium
YG0005930cellular_componentaxoneme
YG0007286biological_processspermatid development
YG0008104biological_processintracellular protein localization
YG0030317biological_processflagellated sperm motility
YG0030544molecular_functionHsp70 protein binding
YG0031072molecular_functionheat shock protein binding
YG0031625molecular_functionubiquitin protein ligase binding
YG0031982cellular_componentvesicle
YG0034620biological_processcellular response to unfolded protein
YG0036126cellular_componentsperm flagellum
YG0043005cellular_componentneuron projection
YG0043014molecular_functionalpha-tubulin binding
YG0044297cellular_componentcell body
YG0048487molecular_functionbeta-tubulin binding
YG0051087molecular_functionprotein-folding chaperone binding
YG0051879molecular_functionHsp90 protein binding
YG0097225cellular_componentsperm midpiece
YG0097228cellular_componentsperm principal piece
YG0097229cellular_componentsperm end piece
YG0160112cellular_componentaxonemal B tubule inner sheath
YH0001664molecular_functionG protein-coupled receptor binding
YH0002177cellular_componentmanchette
YH0003779molecular_functionactin binding
YH0005515molecular_functionprotein binding
YH0005739cellular_componentmitochondrion
YH0005829cellular_componentcytosol
YH0005879cellular_componentaxonemal microtubule
YH0005929cellular_componentcilium
YH0005930cellular_componentaxoneme
YH0007286biological_processspermatid development
YH0008104biological_processintracellular protein localization
YH0030317biological_processflagellated sperm motility
YH0030544molecular_functionHsp70 protein binding
YH0031072molecular_functionheat shock protein binding
YH0031625molecular_functionubiquitin protein ligase binding
YH0031982cellular_componentvesicle
YH0034620biological_processcellular response to unfolded protein
YH0036126cellular_componentsperm flagellum
YH0043005cellular_componentneuron projection
YH0043014molecular_functionalpha-tubulin binding
YH0044297cellular_componentcell body
YH0048487molecular_functionbeta-tubulin binding
YH0051087molecular_functionprotein-folding chaperone binding
YH0051879molecular_functionHsp90 protein binding
YH0097225cellular_componentsperm midpiece
YH0097228cellular_componentsperm principal piece
YH0097229cellular_componentsperm end piece
YH0160112cellular_componentaxonemal B tubule inner sheath
Z0005879cellular_componentaxonemal microtubule
Z0005930cellular_componentaxoneme
Z0030317biological_processflagellated sperm motility
Z0036064cellular_componentciliary basal body
Z0036126cellular_componentsperm flagellum
Z0048814biological_processregulation of dendrite morphogenesis
Z0051124biological_processsynaptic assembly at neuromuscular junction
Z0160111cellular_componentaxonemal A tubule inner sheath
Z1990830biological_processcellular response to leukemia inhibitory factor
Z20003674molecular_functionmolecular_function
Z20005929cellular_componentcilium
Z20008150biological_processbiological_process
Z20015630cellular_componentmicrotubule cytoskeleton
Z20030317biological_processflagellated sperm motility
Z20036064cellular_componentciliary basal body
Z20036126cellular_componentsperm flagellum
Z20160111cellular_componentaxonemal A tubule inner sheath
Z30003674molecular_functionmolecular_function
Z30005929cellular_componentcilium
Z30008150biological_processbiological_process
Z30015630cellular_componentmicrotubule cytoskeleton
Z30030317biological_processflagellated sperm motility
Z30036064cellular_componentciliary basal body
Z30036126cellular_componentsperm flagellum
Z30160111cellular_componentaxonemal A tubule inner sheath
Z40003674molecular_functionmolecular_function
Z40005929cellular_componentcilium
Z40008150biological_processbiological_process
Z40015630cellular_componentmicrotubule cytoskeleton
Z40030317biological_processflagellated sperm motility
Z40036064cellular_componentciliary basal body
Z40036126cellular_componentsperm flagellum
Z40160111cellular_componentaxonemal A tubule inner sheath
Z50003674molecular_functionmolecular_function
Z50005929cellular_componentcilium
Z50008150biological_processbiological_process
Z50015630cellular_componentmicrotubule cytoskeleton
Z50030317biological_processflagellated sperm motility
Z50036064cellular_componentciliary basal body
Z50036126cellular_componentsperm flagellum
Z50160111cellular_componentaxonemal A tubule inner sheath
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DVDQDGLINylEF
ChainResidueDetails
1ASP630-PHE642
BaASP94-PHE106

site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGSYSKVKvAtskkykgt..........VAIK
ChainResidueDetails
X6ILE18-LYS41

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LvHrDLKceNVLL
ChainResidueDetails
X6LEU131-LEU143

site_idPS00227
Number of Residues7
DetailsTUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
ChainResidueDetails
AKGLY142-GLY148
BLGLY140-GLY146

site_idPS00228
Number of Residues4
DetailsTUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
ChainResidueDetails
BLMET1-ILE4

site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. LHCaaGvsRSA
ChainResidueDetails
O1LEU103-ALA113

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. CVTAstDgTCIIWDL
ChainResidueDetails
eCYS476-LEU490

site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. ALTwPgqGVYYDfpkFvE
ChainResidueDetails
LaALA217-GLU234

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsRegion: {"description":"Mn","evidences":[{"source":"UniProtKB","id":"Q5VTT2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues140
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues140
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues3
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues43
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues578
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues5902
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues264
DetailsDomain: {"description":"DM10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00665","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues15
DetailsRegion: {"description":"Mn 1","evidences":[{"source":"UniProtKB","id":"Q8N1D5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues12
DetailsRegion: {"description":"Mn 2","evidences":[{"source":"UniProtKB","id":"Q8N1D5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues501
DetailsMotif: {"description":"MREC motif","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues167
DetailsActive site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues1506
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues50
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9BQE3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues167
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68366","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues167
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68368","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues167
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9BQE3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues109
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9BQE3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues510
DetailsMotif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues1190
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues170
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P68371","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues170
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues170
DetailsModified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"P68371","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI24
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"UniProtKB","id":"Q2T9S0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI25
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19144319","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI26
Number of Residues3
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q66HC0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI27
Number of Residues37
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI28
Number of Residues28
DetailsRegion: {"description":"Mn 2","evidences":[{"source":"UniProtKB","id":"Q99932","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI29
Number of Residues13
DetailsRegion: {"description":"Mn 1","evidences":[{"source":"UniProtKB","id":"Q99932","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI30
Number of Residues13
DetailsCompositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI31
Number of Residues11
DetailsRegion: {"description":"Mn 1","evidences":[{"source":"UniProtKB","id":"Q9H5F2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI32
Number of Residues564
DetailsDomain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI33
Number of Residues340
DetailsRegion: {"description":"Sufficient for mitochondrial localization"}
ChainResidueDetails

site_idSWS_FT_FI34
Number of Residues4
DetailsActive site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"37295417","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI35
Number of Residues638
DetailsDomain: {"description":"DM10 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00665","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI36
Number of Residues480
DetailsDomain: {"description":"DM10 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00665","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI37
Number of Residues740
DetailsDomain: {"description":"DM10 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00665","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI38
Number of Residues140
DetailsDomain: {"description":"EF-hand"}
ChainResidueDetails

site_idSWS_FT_FI39
Number of Residues11
DetailsCompositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI40
Number of Residues765
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI41
Number of Residues3
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q9BXA6","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI42
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9D2E1","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI43
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9BXA6","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI44
Number of Residues100
DetailsRepeat: {"description":"STPGR 1"}
ChainResidueDetails

site_idSWS_FT_FI45
Number of Residues100
DetailsRepeat: {"description":"STPGR 2"}
ChainResidueDetails

site_idSWS_FT_FI46
Number of Residues56
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI47
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI48
Number of Residues132
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails

site_idSWS_FT_FI49
Number of Residues123
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails

site_idSWS_FT_FI50
Number of Residues117
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails

site_idSWS_FT_FI51
Number of Residues117
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails

site_idSWS_FT_FI52
Number of Residues117
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails

site_idSWS_FT_FI53
Number of Residues117
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails

site_idSWS_FT_FI54
Number of Residues117
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails

site_idSWS_FT_FI55
Number of Residues117
DetailsRepeat: {"description":"WD 8"}
ChainResidueDetails

site_idSWS_FT_FI56
Number of Residues123
DetailsRepeat: {"description":"WD 9"}
ChainResidueDetails

site_idSWS_FT_FI57
Number of Residues117
DetailsRepeat: {"description":"WD 10"}
ChainResidueDetails

site_idSWS_FT_FI58
Number of Residues368
DetailsDomain: {"description":"Enkurin","evidences":[{"source":"PROSITE-ProRule","id":"PRU01000","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI59
Number of Residues44
DetailsDomain: {"description":"IQ"}
ChainResidueDetails

site_idSWS_FT_FI60
Number of Residues24
DetailsMotif: {"description":"SH3-binding","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI61
Number of Residues30
DetailsCompositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI62
Number of Residues75
DetailsDomain: {"description":"EF-hand 12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI63
Number of Residues90
DetailsDomain: {"description":"EF-hand 14","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

256158

PDB entries from 2026-07-08

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