9V0J

Cryo-EM structure of GATOR1-KICSTOR complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005765	cellular_component	lysosomal membrane
A	0005774	cellular_component	vacuolar membrane
A	0033673	biological_process	negative regulation of kinase activity
A	0034198	biological_process	cellular response to amino acid starvation
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1990130	cellular_component	GATOR1 complex
B	0005515	molecular_function	protein binding
B	0005765	cellular_component	lysosomal membrane
B	0010508	biological_process	positive regulation of autophagy
B	0032007	biological_process	negative regulation of TOR signaling
B	0034198	biological_process	cellular response to amino acid starvation
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1990130	cellular_component	GATOR1 complex
C	0005096	molecular_function	GTPase activator activity
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005765	cellular_component	lysosomal membrane
C	0005829	cellular_component	cytosol
C	0010508	biological_process	positive regulation of autophagy
C	0031267	molecular_function	small GTPase binding
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0034198	biological_process	cellular response to amino acid starvation
C	0035556	biological_process	intracellular signal transduction
C	0044877	molecular_function	protein-containing complex binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1990130	cellular_component	GATOR1 complex
D	0005515	molecular_function	protein binding
D	0005765	cellular_component	lysosomal membrane
D	0005777	cellular_component	peroxisome
D	0007417	biological_process	central nervous system development
D	0009791	biological_process	post-embryonic development
D	0021540	biological_process	corpus callosum morphogenesis
D	0031667	biological_process	response to nutrient levels
D	0034198	biological_process	cellular response to amino acid starvation
D	0042149	biological_process	cellular response to glucose starvation
D	0061462	biological_process	protein localization to lysosome
D	0061700	cellular_component	GATOR2 complex
D	0140007	cellular_component	KICSTOR complex
D	1901668	biological_process	regulation of superoxide dismutase activity
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1990130	cellular_component	GATOR1 complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Arginine finger","evidences":[{"source":"PubMed","id":"30651352","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Asymmetric dimethylarginine","evidences":[{"source":"PubMed","id":"38006878","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36528027","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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