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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9UX3

Cryo-EM structure of the human P2X2/3 heteromer receptor bound to AF-219

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001614molecular_functionpurinergic nucleotide receptor activity
A0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0010524biological_processpositive regulation of calcium ion transport into cytosol
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0030424cellular_componentaxon
A0035590biological_processpurinergic nucleotide receptor signaling pathway
A0043005cellular_componentneuron projection
A0043235cellular_componentsignaling receptor complex
A0050804biological_processmodulation of chemical synaptic transmission
A0050850biological_processpositive regulation of calcium-mediated signaling
A0055085biological_processtransmembrane transport
A0060079biological_processexcitatory postsynaptic potential
A0070207biological_processprotein homotrimerization
A0070588biological_processcalcium ion transmembrane transport
A0071318biological_processcellular response to ATP
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098686cellular_componenthippocampal mossy fiber to CA3 synapse
A0098794cellular_componentpostsynapse
B0001614molecular_functionpurinergic nucleotide receptor activity
B0002931biological_processresponse to ischemia
B0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0007605biological_processsensory perception of sound
B0010524biological_processpositive regulation of calcium ion transport into cytosol
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016324cellular_componentapical plasma membrane
B0035590biological_processpurinergic nucleotide receptor signaling pathway
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043235cellular_componentsignaling receptor complex
B0050850biological_processpositive regulation of calcium-mediated signaling
B0060079biological_processexcitatory postsynaptic potential
B0070588biological_processcalcium ion transmembrane transport
B0098794cellular_componentpostsynapse
B0098992cellular_componentneuronal dense core vesicle
C0001614molecular_functionpurinergic nucleotide receptor activity
C0002931biological_processresponse to ischemia
C0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0007605biological_processsensory perception of sound
C0010524biological_processpositive regulation of calcium ion transport into cytosol
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016324cellular_componentapical plasma membrane
C0035590biological_processpurinergic nucleotide receptor signaling pathway
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043235cellular_componentsignaling receptor complex
C0050850biological_processpositive regulation of calcium-mediated signaling
C0060079biological_processexcitatory postsynaptic potential
C0070588biological_processcalcium ion transmembrane transport
C0098794cellular_componentpostsynapse
C0098992cellular_componentneuronal dense core vesicle
Functional Information from PROSITE/UniProt
site_idPS01212
Number of Residues27
DetailsP2X_RECEPTOR ATP P2X receptors signature. GGvLGIkIgWvCDLDkawdqCiPkYsF
ChainResidueDetails
AGLY236-PHE262
BGLY259-PHE285
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues278
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues546
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues26
DetailsRegion: {"description":"Pore-forming motif","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2026-05-27

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