9UGP
Crystal structure of MCL-1 in complex with HRK BH3
Functional Information from PROSITE/UniProt
| site_id | PS01080 |
| Number of Residues | 20 |
| Details | BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFsDGvtNWGRIVTLIsFGA |
| Chain | Residue | Details |
| A | VAL253-ALA272 |
| site_id | PS01258 |
| Number of Residues | 12 |
| Details | BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV |
| Chain | Residue | Details |
| A | TRP305-VAL316 |
| site_id | PS01259 |
| Number of Residues | 15 |
| Details | BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. TaarLKaLGDELHQR |
| Chain | Residue | Details |
| B | THR33-ARG47 | |
| A | ALA209-ASN223 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Motif: {"description":"BH3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Motif: {"description":"BH1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | Motif: {"description":"BH2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"} |
| Chain | Residue | Details |
