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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9UED

Cryo-EM structure of human TRPV3 in complex with sevoflurane determined in MSP2N2 nanodisc

This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues116
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues48
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues24
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues152
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues100
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues144
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues112
DetailsRepeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues116
DetailsRepeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues120
DetailsRepeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues128
DetailsRepeat: {"description":"ANK 5","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues88
DetailsRepeat: {"description":"ANK 6","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues88
DetailsRepeat: {"description":"ANK 7","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

251801

PDB entries from 2026-04-08

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