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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9UCO

Cryo-EM structure of ADGRE1-beta arrestin1-scFv30 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000822molecular_functioninositol hexakisphosphate binding
A0001664molecular_functionG protein-coupled receptor binding
A0001934biological_processpositive regulation of protein phosphorylation
A0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
A0002031biological_processG protein-coupled receptor internalization
A0002092biological_processpositive regulation of receptor internalization
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005905cellular_componentclathrin-coated pit
A0006511biological_processubiquitin-dependent protein catabolic process
A0006898biological_processreceptor-mediated endocytosis
A0007600biological_processsensory perception
A0008277biological_processregulation of G protein-coupled receptor signaling pathway
A0009968biological_processnegative regulation of signal transduction
A0030132cellular_componentclathrin coat of coated pit
A0030276molecular_functionclathrin binding
A0031143cellular_componentpseudopodium
A0031410cellular_componentcytoplasmic vesicle
A0031623biological_processreceptor internalization
A0032050molecular_functionclathrin heavy chain binding
A0033130molecular_functionacetylcholine receptor binding
A0035612molecular_functionAP-2 adaptor complex binding
A0036094molecular_functionsmall molecule binding
A0045746biological_processnegative regulation of Notch signaling pathway
A0045880biological_processpositive regulation of smoothened signaling pathway
A0060090molecular_functionmolecular adaptor activity
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0072583biological_processclathrin-dependent endocytosis
A0097499biological_processprotein localization to non-motile cilium
C0000822molecular_functioninositol hexakisphosphate binding
C0001664molecular_functionG protein-coupled receptor binding
C0001934biological_processpositive regulation of protein phosphorylation
C0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
C0002031biological_processG protein-coupled receptor internalization
C0002092biological_processpositive regulation of receptor internalization
C0005102molecular_functionsignaling receptor binding
C0005515molecular_functionprotein binding
C0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005905cellular_componentclathrin-coated pit
C0006511biological_processubiquitin-dependent protein catabolic process
C0006898biological_processreceptor-mediated endocytosis
C0007600biological_processsensory perception
C0008277biological_processregulation of G protein-coupled receptor signaling pathway
C0009968biological_processnegative regulation of signal transduction
C0030132cellular_componentclathrin coat of coated pit
C0030276molecular_functionclathrin binding
C0031143cellular_componentpseudopodium
C0031410cellular_componentcytoplasmic vesicle
C0031623biological_processreceptor internalization
C0032050molecular_functionclathrin heavy chain binding
C0033130molecular_functionacetylcholine receptor binding
C0035612molecular_functionAP-2 adaptor complex binding
C0036094molecular_functionsmall molecule binding
C0045746biological_processnegative regulation of Notch signaling pathway
C0045880biological_processpositive regulation of smoothened signaling pathway
C0060090molecular_functionmolecular adaptor activity
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0072583biological_processclathrin-dependent endocytosis
C0097499biological_processprotein localization to non-motile cilium
Functional Information from PROSITE/UniProt
site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
APHE61-LEU79
site_idPS00650
Number of Residues16
DetailsG_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGAFIfLIHCLlNrqV
ChainResidueDetails
RGLN881-VAL896
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues41
DetailsRegion: {"description":"Interaction with CHRM2"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues12
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues76
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues56
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues38
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

255615

PDB entries from 2026-06-24

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