9U3P
Cryo-EM structure of human AC9-Gs complex (soluble domain)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001701 | biological_process | in utero embryonic development |
| A | 0003091 | biological_process | renal water homeostasis |
| A | 0004016 | molecular_function | adenylate cyclase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005929 | cellular_component | cilium |
| A | 0006171 | biological_process | cAMP biosynthetic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0016829 | molecular_function | lyase activity |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0036064 | cellular_component | ciliary basal body |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071377 | biological_process | cellular response to glucagon stimulus |
| A | 0071880 | biological_process | adenylate cyclase-activating adrenergic receptor signaling pathway |
| A | 0097700 | biological_process | vascular endothelial cell response to laminar fluid shear stress |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0001678 | biological_process | intracellular glucose homeostasis |
| B | 0002862 | biological_process | negative regulation of inflammatory response to antigenic stimulus |
| B | 0003091 | biological_process | renal water homeostasis |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| B | 0007190 | biological_process | activation of adenylate cyclase activity |
| B | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| B | 0007192 | biological_process | adenylate cyclase-activating serotonin receptor signaling pathway |
| B | 0007608 | biological_process | sensory perception of smell |
| B | 0010856 | molecular_function | adenylate cyclase activator activity |
| B | 0014819 | biological_process | regulation of skeletal muscle contraction |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0031748 | molecular_function | D1 dopamine receptor binding |
| B | 0032024 | biological_process | positive regulation of insulin secretion |
| B | 0032588 | cellular_component | trans-Golgi network membrane |
| B | 0034695 | biological_process | response to prostaglandin E |
| B | 0035774 | biological_process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| B | 0038184 | biological_process | adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046907 | biological_process | intracellular transport |
| B | 0048589 | biological_process | developmental growth |
| B | 0050890 | biological_process | cognition |
| B | 0060348 | biological_process | bone development |
| B | 0060789 | biological_process | hair follicle placode formation |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070527 | biological_process | platelet aggregation |
| B | 0071377 | biological_process | cellular response to glucagon stimulus |
| B | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| B | 0071468 | biological_process | cellular response to acidic pH |
| B | 0071870 | biological_process | cellular response to catecholamine stimulus |
| B | 0071880 | biological_process | adenylate cyclase-activating adrenergic receptor signaling pathway |
| B | 0097700 | biological_process | vascular endothelial cell response to laminar fluid shear stress |
| B | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
Functional Information from PROSITE/UniProt
| site_id | PS00452 |
| Number of Residues | 24 |
| Details | GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GIL.GmrrfkFdVWSNDVNlanlmE |
| Chain | Residue | Details |
| A | GLY498-GLU521 | |
| A | GLY1175-ASP1198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 127 |
| Details | Domain: {"description":"Guanylate cyclase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 140 |
| Details | Domain: {"description":"Guanylate cyclase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P30803","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P26769","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 13 |
| Details | Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | Region: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 9 |
| Details | Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 7 |
| Details | Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 5 |
| Details | Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 25 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P04896","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylarginine; by cholera toxin","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"} |
| Chain | Residue | Details |
