9U3P
Cryo-EM structure of human AC9-Gs complex (soluble domain)
Functional Information from PROSITE/UniProt
| site_id | PS00452 |
| Number of Residues | 24 |
| Details | GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GIL.GmrrfkFdVWSNDVNlanlmE |
| Chain | Residue | Details |
| A | GLY498-GLU521 | |
| A | GLY1175-ASP1198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P04896 |
| Chain | Residue | Details |
| B | GLY47 | |
| B | SER54 | |
| B | LEU197 | |
| B | THR204 | |
| B | ASP223 | |
| B | ASN292 | |
| B | ALA366 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250 |
| Chain | Residue | Details |
| B | ARG201 | |
| A | ILE892-PHE912 | |
| A | SER921-PRO941 | |
| A | SER976-LEU996 | |
| A | LEU142-PHE162 | |
| A | TYR172-PHE192 | |
| A | THR216-TYR235 | |
| A | LEU242-PHE259 | |
| A | LEU281-MET301 | |
| A | SER787-LEU807 | |
| A | ALA819-ILE839 | |
| A | ILE868-TYR888 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| B | SER352 | |
| A | GLN193-ASP215 | |
| A | GLY260-GLU280 | |
| A | LYS808-PRO818 | |
| A | GLU889-ASN891 | |
| A | ASP942-ALA975 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | LIPID: N-palmitoyl glycine => ECO:0000250|UniProtKB:P04896 |
| Chain | Residue | Details |
| B | GLY2 | |
| A | ILE400 | |
| A | ASP443 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:21044946 |
| Chain | Residue | Details |
| B | CYS3 | |
| A | ARG487 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| B | LYS300 | |
| A | ASP1185 | |
| A | ASN1192 | |
| A | LYS1232 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P51830 |
| Chain | Residue | Details |
| A | SER610 | |
| A | SER688 | |
| A | SER691 | |
| A | SER1295 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER706 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1257 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1259 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER1307 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN206 | |
| A | ASN955 | |
| A | ASN964 |
