9TI4

High resolution Cryo-EM structure of human complex I in mitochondria

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
b	0005515	molecular_function	protein binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
b	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
b	0009060	biological_process	aerobic respiration
b	0031966	cellular_component	mitochondrial membrane
b	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
b	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
b	0045271	cellular_component	respiratory chain complex I
b	1902600	biological_process	proton transmembrane transport
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0009060	biological_process	aerobic respiration
C	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
C	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
C	0045271	cellular_component	respiratory chain complex I
C	1902600	biological_process	proton transmembrane transport
d	0005515	molecular_function	protein binding
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
d	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
d	0009060	biological_process	aerobic respiration
d	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
d	0045271	cellular_component	respiratory chain complex I
d	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0009060	biological_process	aerobic respiration
F	0031966	cellular_component	mitochondrial membrane
F	0032981	biological_process	mitochondrial respiratory chain complex I assembly
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0045271	cellular_component	respiratory chain complex I
F	1902600	biological_process	proton transmembrane transport
g	0005515	molecular_function	protein binding
g	0005737	cellular_component	cytoplasm
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005886	cellular_component	plasma membrane
g	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
g	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
g	0009060	biological_process	aerobic respiration
g	0010918	biological_process	positive regulation of mitochondrial membrane potential
g	0032981	biological_process	mitochondrial respiratory chain complex I assembly
g	0035577	cellular_component	azurophil granule membrane
g	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
g	0045271	cellular_component	respiratory chain complex I
g	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
g	1902600	biological_process	proton transmembrane transport
g	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
g	2001171	biological_process	positive regulation of ATP biosynthetic process
h	0005515	molecular_function	protein binding
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005758	cellular_component	mitochondrial intermembrane space
h	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
h	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
h	0009060	biological_process	aerobic respiration
h	0032981	biological_process	mitochondrial respiratory chain complex I assembly
h	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
h	0045271	cellular_component	respiratory chain complex I
h	1902600	biological_process	proton transmembrane transport
i	0001666	biological_process	response to hypoxia
i	0005515	molecular_function	protein binding
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
i	0009060	biological_process	aerobic respiration
i	0019901	molecular_function	protein kinase binding
i	0032981	biological_process	mitochondrial respiratory chain complex I assembly
i	0035255	molecular_function	ionotropic glutamate receptor binding
i	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
i	0045271	cellular_component	respiratory chain complex I
i	1902600	biological_process	proton transmembrane transport
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
I	0009060	biological_process	aerobic respiration
I	0022904	biological_process	respiratory electron transport chain
I	0032991	cellular_component	protein-containing complex
I	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
I	0045271	cellular_component	respiratory chain complex I
I	1902600	biological_process	proton transmembrane transport
j	0005515	molecular_function	protein binding
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
j	0006979	biological_process	response to oxidative stress
j	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
j	0009060	biological_process	aerobic respiration
j	0009642	biological_process	response to light intensity
j	0009725	biological_process	response to hormone
j	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
j	0045271	cellular_component	respiratory chain complex I
j	0071385	biological_process	cellular response to glucocorticoid stimulus
j	1902600	biological_process	proton transmembrane transport
J	0003954	molecular_function	NADH dehydrogenase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005759	cellular_component	mitochondrial matrix
J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
J	0006744	biological_process	ubiquinone biosynthetic process
J	0006814	biological_process	sodium ion transport
J	0007623	biological_process	circadian rhythm
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0009060	biological_process	aerobic respiration
J	0031966	cellular_component	mitochondrial membrane
J	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
J	0044877	molecular_function	protein-containing complex binding
J	0045271	cellular_component	respiratory chain complex I
J	1902600	biological_process	proton transmembrane transport
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
k	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
k	0009060	biological_process	aerobic respiration
k	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
k	0045271	cellular_component	respiratory chain complex I
k	1902600	biological_process	proton transmembrane transport
l	0001666	biological_process	response to hypoxia
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
l	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
l	0009060	biological_process	aerobic respiration
l	0015990	biological_process	electron transport coupled proton transport
l	0032981	biological_process	mitochondrial respiratory chain complex I assembly
l	0042542	biological_process	response to hydrogen peroxide
l	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
l	0045271	cellular_component	respiratory chain complex I
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
m	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
m	0009060	biological_process	aerobic respiration
m	0032981	biological_process	mitochondrial respiratory chain complex I assembly
m	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
m	0045271	cellular_component	respiratory chain complex I
m	1902600	biological_process	proton transmembrane transport
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005759	cellular_component	mitochondrial matrix
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009055	molecular_function	electron transfer activity
M	0009060	biological_process	aerobic respiration
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
M	0045271	cellular_component	respiratory chain complex I
M	0045333	biological_process	cellular respiration
M	1902600	biological_process	proton transmembrane transport
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
n	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
n	0009060	biological_process	aerobic respiration
n	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
n	0045271	cellular_component	respiratory chain complex I
n	1902600	biological_process	proton transmembrane transport
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0009060	biological_process	aerobic respiration
N	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
N	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
N	0045271	cellular_component	respiratory chain complex I
N	1902600	biological_process	proton transmembrane transport
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
o	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
o	0009060	biological_process	aerobic respiration
o	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
o	0045271	cellular_component	respiratory chain complex I
o	1902600	biological_process	proton transmembrane transport
p	0005515	molecular_function	protein binding
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
p	0007605	biological_process	sensory perception of sound
p	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
p	0009060	biological_process	aerobic respiration
p	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
p	0045271	cellular_component	respiratory chain complex I
p	1902600	biological_process	proton transmembrane transport
Q	0003954	molecular_function	NADH dehydrogenase activity
Q	0005515	molecular_function	protein binding
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005759	cellular_component	mitochondrial matrix
Q	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Q	0009055	molecular_function	electron transfer activity
Q	0009060	biological_process	aerobic respiration
Q	0019826	molecular_function	oxygen sensor activity
Q	0022008	biological_process	neurogenesis
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Q	0042063	biological_process	gliogenesis
Q	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
Q	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Q	0045271	cellular_component	respiratory chain complex I
Q	0061351	biological_process	neural precursor cell proliferation
Q	0071453	biological_process	cellular response to oxygen levels
Q	1902600	biological_process	proton transmembrane transport
r	0001666	biological_process	response to hypoxia
r	0001701	biological_process	in utero embryonic development
r	0003954	molecular_function	NADH dehydrogenase activity
r	0005739	cellular_component	mitochondrion
r	0005743	cellular_component	mitochondrial inner membrane
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
r	0009060	biological_process	aerobic respiration
r	0015990	biological_process	electron transport coupled proton transport
r	0021549	biological_process	cerebellum development
r	0032981	biological_process	mitochondrial respiratory chain complex I assembly
r	0035094	biological_process	response to nicotine
r	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
r	0045271	cellular_component	respiratory chain complex I
r	0045471	biological_process	response to ethanol
r	0048039	molecular_function	ubiquinone binding
s	0003954	molecular_function	NADH dehydrogenase activity
s	0005515	molecular_function	protein binding
s	0005739	cellular_component	mitochondrion
s	0005743	cellular_component	mitochondrial inner membrane
s	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
s	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
s	0009060	biological_process	aerobic respiration
s	0031966	cellular_component	mitochondrial membrane
s	0032981	biological_process	mitochondrial respiratory chain complex I assembly
s	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
s	0045271	cellular_component	respiratory chain complex I
s	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S	0009060	biological_process	aerobic respiration
S	0031966	cellular_component	mitochondrial membrane
S	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
S	0045271	cellular_component	respiratory chain complex I
S	1902600	biological_process	proton transmembrane transport
t	0005515	molecular_function	protein binding
t	0005739	cellular_component	mitochondrion
t	0005743	cellular_component	mitochondrial inner membrane
t	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
t	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
t	0009060	biological_process	aerobic respiration
t	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
t	0045271	cellular_component	respiratory chain complex I
t	1902600	biological_process	proton transmembrane transport
u	0005515	molecular_function	protein binding
u	0005739	cellular_component	mitochondrion
u	0005743	cellular_component	mitochondrial inner membrane
u	0005758	cellular_component	mitochondrial intermembrane space
u	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
u	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
u	0009060	biological_process	aerobic respiration
u	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
u	0044877	molecular_function	protein-containing complex binding
u	0045271	cellular_component	respiratory chain complex I
u	1902600	biological_process	proton transmembrane transport
U	0005515	molecular_function	protein binding
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
U	0009060	biological_process	aerobic respiration
U	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
U	0045271	cellular_component	respiratory chain complex I
U	1902600	biological_process	proton transmembrane transport
V	0005515	molecular_function	protein binding
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0009060	biological_process	aerobic respiration
V	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
V	0045271	cellular_component	respiratory chain complex I
w	0005737	cellular_component	cytoplasm
w	0005739	cellular_component	mitochondrion
w	0005743	cellular_component	mitochondrial inner membrane
w	0005759	cellular_component	mitochondrial matrix
w	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
w	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
w	0009060	biological_process	aerobic respiration
w	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
w	0045271	cellular_component	respiratory chain complex I
w	1902600	biological_process	proton transmembrane transport
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0009060	biological_process	aerobic respiration
W	0031966	cellular_component	mitochondrial membrane
W	0032981	biological_process	mitochondrial respiratory chain complex I assembly
W	0035458	biological_process	cellular response to interferon-beta
W	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
W	0045039	biological_process	protein insertion into mitochondrial inner membrane
W	0045271	cellular_component	respiratory chain complex I
W	0045732	biological_process	positive regulation of protein catabolic process
W	0045892	biological_process	negative regulation of DNA-templated transcription
W	0061133	molecular_function	endopeptidase activator activity
W	0071300	biological_process	cellular response to retinoic acid
W	0098803	cellular_component	respiratory chain complex
W	1900119	biological_process	positive regulation of execution phase of apoptosis

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
H	ASP107-MET122

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
H	ASP132-ILE144

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP

Chain	Residue	Details
D	CYS111-PRO122
D	CYS150-PRO161

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
Q	LEU116-LYS127

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
P	GLU167-LEU188

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
M	PRO61-CYS78

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
M	CYS128-GLN140

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
M	ARG175-PHE185

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
C	GLY200-SER215

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
C	GLU377-GLY388

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpFaDAMKLFtKE

Chain	Residue	Details
s	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLAEGEseLVs.G

Chain	Residue	Details
s	PRO197-GLY210

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
O	ASP166-PRO184

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYiPgCPP

Chain	Residue	Details
E	GLY169-PRO185

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	65
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q91YT0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91YT0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q91YT0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Hydroxyarginine","evidences":[{"source":"PubMed","id":"27226634","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CQ75","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	150
Details	Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CR21","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31664822","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ODD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CPP6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CPP6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9DC69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DC69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	128
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"20433953","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	78
Details	Domain: {"description":"2Fe-2S ferredoxin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00465","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	39
Details	Domain: {"description":"4Fe-4S His(Cys)3-ligated-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	56
Details	Domain: {"description":"4Fe-4S Mo/W bis-MGD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01004","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91VD9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04394","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"5XTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D6J6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"22823520","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91WD5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"Symmetric dimethylarginine","evidences":[{"source":"PubMed","id":"24089531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24838397","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1377
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52503","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q02371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q8HXG6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	42
Details	Region: {"description":"Important for inducing cell death"}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CQZ6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3UIU2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	10
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	86
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	30
Details	Motif: {"description":"Cx9C motif 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	30
Details	Motif: {"description":"Cx9C motif 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	41
Details	Domain: {"description":"CHCH 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	43
Details	Domain: {"description":"CHCH 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	10
Details	Motif: {"description":"Cx9C motif 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	10
Details	Motif: {"description":"Cx9C motif 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI53
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CR61","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI54
Number of Residues	1
Details	Lipidation: {"description":"N-myristoyl glycine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI55
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PINK1","evidences":[{"source":"UniProtKB","id":"Q99LC3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI56
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99LC3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q05752","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI58
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Z1P6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI59
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---