9T6L

Cryo-EM structure of the human LENG8-PCID2-DSS1 complex bound to UAP56 and RRP1B

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000245	biological_process	spliceosomal complex assembly
B	0000346	cellular_component	transcription export complex
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0003729	molecular_function	mRNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005687	cellular_component	U4 snRNP
B	0005688	cellular_component	U6 snRNP
B	0005737	cellular_component	cytoplasm
B	0006405	biological_process	RNA export from nucleus
B	0006406	biological_process	mRNA export from nucleus
B	0008186	molecular_function	ATP-dependent activity, acting on RNA
B	0008380	biological_process	RNA splicing
B	0016607	cellular_component	nuclear speck
B	0016887	molecular_function	ATP hydrolysis activity
B	0017070	molecular_function	U6 snRNA binding
B	0030621	molecular_function	U4 snRNA binding
B	0042802	molecular_function	identical protein binding
B	0043008	molecular_function	ATP-dependent protein binding
D	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
D	0003690	molecular_function	double-stranded DNA binding
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005643	cellular_component	nuclear pore
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0006406	biological_process	mRNA export from nucleus
D	0016973	biological_process	poly(A)+ mRNA export from nucleus
D	0032991	cellular_component	protein-containing complex
D	0044615	cellular_component	nuclear pore nuclear basket
D	0045579	biological_process	positive regulation of B cell differentiation
D	0045814	biological_process	negative regulation of gene expression, epigenetic
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0048536	biological_process	spleen development
D	0070390	cellular_component	transcription export complex 2
D	1905457	biological_process	negative regulation of lymphoid progenitor cell differentiation
E	0000502	cellular_component	proteasome complex
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005829	cellular_component	cytosol
E	0006406	biological_process	mRNA export from nucleus
E	0006979	biological_process	response to oxidative stress
E	0008021	cellular_component	synaptic vesicle
E	0010498	biological_process	proteasomal protein catabolic process
E	0032039	cellular_component	integrator complex
E	0032991	cellular_component	protein-containing complex
E	0043130	molecular_function	ubiquitin binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0061136	biological_process	regulation of proteasomal protein catabolic process
E	0070390	cellular_component	transcription export complex 2
E	0071357	biological_process	cellular response to type I interferon

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	181
Details	Domain: {"description":"PCI","evidences":[{"source":"PROSITE-ProRule","id":"PRU01185","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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