Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9T5N

Structure of heteromeric mouse LRRC8A/D Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1, Conformation 1

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	116
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	44
Details	Repeat: {"description":"LRR 1","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	88
Details	Repeat: {"description":"LRR 2","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	84
Details	Repeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	92
Details	Repeat: {"description":"LRR 4","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	88
Details	Repeat: {"description":"LRR 5","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	96
Details	Repeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	88
Details	Repeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	88
Details	Repeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	92
Details	Repeat: {"description":"LRR 9","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	92
Details	Repeat: {"description":"LRR 10","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	88
Details	Repeat: {"description":"LRR 11","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	88
Details	Repeat: {"description":"LRR 12","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	84
Details	Repeat: {"description":"LRR 13","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	88
Details	Repeat: {"description":"LRR 14","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	84
Details	Repeat: {"description":"LRR 15","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	88
Details	Repeat: {"description":"LRR 16","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	92
Details	Repeat: {"description":"LRR 17","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	4
Details	Motif: {"description":"Di-leucine motif","evidences":[{"source":"UniProtKB","id":"Q8IWT6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	4
Details	Site: {"description":"Required for anion selectivity","evidences":[{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000303"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8IWT6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"Q7L1W4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"Q7L1W4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"UniProtKB","id":"Q7L1W4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	58
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"Q7L1W4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"Q7L1W4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	40
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	42
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	42
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	40
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	40
Details	Repeat: {"description":"LRR 5"}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	42
Details	Repeat: {"description":"LRR 6"}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	42
Details	Repeat: {"description":"LRR 7"}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	42
Details	Repeat: {"description":"LRR 8"}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	42
Details	Repeat: {"description":"LRR 9"}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	42
Details	Repeat: {"description":"LRR 10"}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	42
Details	Repeat: {"description":"LRR 11"}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	42
Details	Repeat: {"description":"LRR 12"}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	42
Details	Repeat: {"description":"LRR 13"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)