9T33
Cryo-EM structure of homo-hexameric hLRRC8A double mutation W168L/L402W
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30127360","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ZSU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DJB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 108 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30127360","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ZSU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DJB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 126 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30127360","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ZSU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DJB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 174 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 144 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30127360","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ZSU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DJB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Site: {"description":"Required for anion selectivity","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
