9SYU

shutdown state non-muscle myosin 2A heads region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000146	molecular_function	microfilament motor activity
A	0000166	molecular_function	nucleotide binding
A	0000902	biological_process	cell morphogenesis
A	0001525	biological_process	angiogenesis
A	0001618	molecular_function	virus receptor activity
A	0001725	cellular_component	stress fiber
A	0001726	cellular_component	ruffle
A	0001772	cellular_component	immunological synapse
A	0001778	biological_process	plasma membrane repair
A	0001931	cellular_component	uropod
A	0003723	molecular_function	RNA binding
A	0003774	molecular_function	cytoskeletal motor activity
A	0003779	molecular_function	actin binding
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005819	cellular_component	spindle
A	0005826	cellular_component	actomyosin contractile ring
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005903	cellular_component	brush border
A	0005912	cellular_component	adherens junction
A	0005925	cellular_component	focal adhesion
A	0005938	cellular_component	cell cortex
A	0006509	biological_process	membrane protein ectodomain proteolysis
A	0006911	biological_process	phagocytosis, engulfment
A	0007010	biological_process	cytoskeleton organization
A	0007155	biological_process	cell adhesion
A	0007229	biological_process	integrin-mediated signaling pathway
A	0008180	cellular_component	COP9 signalosome
A	0008360	biological_process	regulation of cell shape
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0009986	cellular_component	cell surface
A	0015031	biological_process	protein transport
A	0015629	cellular_component	actin cytoskeleton
A	0016020	cellular_component	membrane
A	0016459	cellular_component	myosin complex
A	0016460	cellular_component	myosin II complex
A	0019904	molecular_function	protein domain specific binding
A	0030029	biological_process	actin filament-based process
A	0030036	biological_process	actin cytoskeleton organization
A	0030048	biological_process	actin filament-based movement
A	0030154	biological_process	cell differentiation
A	0030220	biological_process	platelet formation
A	0030224	biological_process	monocyte differentiation
A	0030863	cellular_component	cortical cytoskeleton
A	0031032	biological_process	actomyosin structure organization
A	0031252	cellular_component	cell leading edge
A	0031410	cellular_component	cytoplasmic vesicle
A	0031594	cellular_component	neuromuscular junction
A	0032154	cellular_component	cleavage furrow
A	0032418	biological_process	lysosome localization
A	0032506	biological_process	cytokinetic process
A	0032970	biological_process	regulation of actin filament-based process
A	0032982	cellular_component	myosin filament
A	0032991	cellular_component	protein-containing complex
A	0042641	cellular_component	actomyosin
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043495	molecular_function	protein-membrane adaptor activity
A	0043531	molecular_function	ADP binding
A	0043534	biological_process	blood vessel endothelial cell migration
A	0045055	biological_process	regulated exocytosis
A	0045296	molecular_function	cadherin binding
A	0046718	biological_process	symbiont entry into host cell
A	0050900	biological_process	leukocyte migration
A	0051015	molecular_function	actin filament binding
A	0060471	biological_process	cortical granule exocytosis
A	0060473	cellular_component	cortical granule
A	0070062	cellular_component	extracellular exosome
A	0070527	biological_process	platelet aggregation
A	0097513	cellular_component	myosin II filament
A	0099512	cellular_component	supramolecular fiber
A	1903919	biological_process	negative regulation of actin filament severing
A	1903923	biological_process	positive regulation of protein processing in phagocytic vesicle
A	1905684	biological_process	regulation of plasma membrane repair
B	0000146	molecular_function	microfilament motor activity
B	0000166	molecular_function	nucleotide binding
B	0000902	biological_process	cell morphogenesis
B	0001525	biological_process	angiogenesis
B	0001618	molecular_function	virus receptor activity
B	0001725	cellular_component	stress fiber
B	0001726	cellular_component	ruffle
B	0001772	cellular_component	immunological synapse
B	0001778	biological_process	plasma membrane repair
B	0001931	cellular_component	uropod
B	0003723	molecular_function	RNA binding
B	0003774	molecular_function	cytoskeletal motor activity
B	0003779	molecular_function	actin binding
B	0005178	molecular_function	integrin binding
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005819	cellular_component	spindle
B	0005826	cellular_component	actomyosin contractile ring
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0005903	cellular_component	brush border
B	0005912	cellular_component	adherens junction
B	0005925	cellular_component	focal adhesion
B	0005938	cellular_component	cell cortex
B	0006509	biological_process	membrane protein ectodomain proteolysis
B	0006911	biological_process	phagocytosis, engulfment
B	0007010	biological_process	cytoskeleton organization
B	0007155	biological_process	cell adhesion
B	0007229	biological_process	integrin-mediated signaling pathway
B	0008180	cellular_component	COP9 signalosome
B	0008360	biological_process	regulation of cell shape
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0009986	cellular_component	cell surface
B	0015031	biological_process	protein transport
B	0015629	cellular_component	actin cytoskeleton
B	0016020	cellular_component	membrane
B	0016459	cellular_component	myosin complex
B	0016460	cellular_component	myosin II complex
B	0019904	molecular_function	protein domain specific binding
B	0030029	biological_process	actin filament-based process
B	0030036	biological_process	actin cytoskeleton organization
B	0030048	biological_process	actin filament-based movement
B	0030154	biological_process	cell differentiation
B	0030220	biological_process	platelet formation
B	0030224	biological_process	monocyte differentiation
B	0030863	cellular_component	cortical cytoskeleton
B	0031032	biological_process	actomyosin structure organization
B	0031252	cellular_component	cell leading edge
B	0031410	cellular_component	cytoplasmic vesicle
B	0031594	cellular_component	neuromuscular junction
B	0032154	cellular_component	cleavage furrow
B	0032418	biological_process	lysosome localization
B	0032506	biological_process	cytokinetic process
B	0032970	biological_process	regulation of actin filament-based process
B	0032982	cellular_component	myosin filament
B	0032991	cellular_component	protein-containing complex
B	0042641	cellular_component	actomyosin
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043495	molecular_function	protein-membrane adaptor activity
B	0043531	molecular_function	ADP binding
B	0043534	biological_process	blood vessel endothelial cell migration
B	0045055	biological_process	regulated exocytosis
B	0045296	molecular_function	cadherin binding
B	0046718	biological_process	symbiont entry into host cell
B	0050900	biological_process	leukocyte migration
B	0051015	molecular_function	actin filament binding
B	0060471	biological_process	cortical granule exocytosis
B	0060473	cellular_component	cortical granule
B	0070062	cellular_component	extracellular exosome
B	0070527	biological_process	platelet aggregation
B	0097513	cellular_component	myosin II filament
B	0099512	cellular_component	supramolecular fiber
B	1903919	biological_process	negative regulation of actin filament severing
B	1903923	biological_process	positive regulation of protein processing in phagocytic vesicle
B	1905684	biological_process	regulation of plasma membrane repair
C	0000146	molecular_function	microfilament motor activity
C	0000287	molecular_function	magnesium ion binding
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005859	cellular_component	muscle myosin complex
C	0008307	molecular_function	structural constituent of muscle
C	0016459	cellular_component	myosin complex
C	0016460	cellular_component	myosin II complex
C	0030239	biological_process	myofibril assembly
C	0031032	biological_process	actomyosin structure organization
C	0032036	molecular_function	myosin heavy chain binding
C	0042641	cellular_component	actomyosin
C	0043531	molecular_function	ADP binding
C	0045159	molecular_function	myosin II binding
C	0051015	molecular_function	actin filament binding
C	0097513	cellular_component	myosin II filament
D	0000146	molecular_function	microfilament motor activity
D	0000287	molecular_function	magnesium ion binding
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0005859	cellular_component	muscle myosin complex
D	0008307	molecular_function	structural constituent of muscle
D	0016459	cellular_component	myosin complex
D	0016460	cellular_component	myosin II complex
D	0030239	biological_process	myofibril assembly
D	0031032	biological_process	actomyosin structure organization
D	0032036	molecular_function	myosin heavy chain binding
D	0042641	cellular_component	actomyosin
D	0043531	molecular_function	ADP binding
D	0045159	molecular_function	myosin II binding
D	0051015	molecular_function	actin filament binding
D	0097513	cellular_component	myosin II filament
E	0000146	molecular_function	microfilament motor activity
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005938	cellular_component	cell cortex
E	0016459	cellular_component	myosin complex
E	0016460	cellular_component	myosin II complex
E	0031032	biological_process	actomyosin structure organization
E	0032036	molecular_function	myosin heavy chain binding
E	0042641	cellular_component	actomyosin
E	0046872	molecular_function	metal ion binding
E	0051015	molecular_function	actin filament binding
E	0097513	cellular_component	myosin II filament
F	0000146	molecular_function	microfilament motor activity
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005938	cellular_component	cell cortex
F	0016459	cellular_component	myosin complex
F	0016460	cellular_component	myosin II complex
F	0031032	biological_process	actomyosin structure organization
F	0032036	molecular_function	myosin heavy chain binding
F	0042641	cellular_component	actomyosin
F	0046872	molecular_function	metal ion binding
F	0051015	molecular_function	actin filament binding
F	0097513	cellular_component	myosin II filament
G	0000146	molecular_function	microfilament motor activity
G	0000166	molecular_function	nucleotide binding
G	0000902	biological_process	cell morphogenesis
G	0001525	biological_process	angiogenesis
G	0001618	molecular_function	virus receptor activity
G	0001725	cellular_component	stress fiber
G	0001726	cellular_component	ruffle
G	0001772	cellular_component	immunological synapse
G	0001778	biological_process	plasma membrane repair
G	0001931	cellular_component	uropod
G	0003723	molecular_function	RNA binding
G	0003774	molecular_function	cytoskeletal motor activity
G	0003779	molecular_function	actin binding
G	0005178	molecular_function	integrin binding
G	0005515	molecular_function	protein binding
G	0005516	molecular_function	calmodulin binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005794	cellular_component	Golgi apparatus
G	0005819	cellular_component	spindle
G	0005826	cellular_component	actomyosin contractile ring
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0005903	cellular_component	brush border
G	0005912	cellular_component	adherens junction
G	0005925	cellular_component	focal adhesion
G	0005938	cellular_component	cell cortex
G	0006509	biological_process	membrane protein ectodomain proteolysis
G	0006911	biological_process	phagocytosis, engulfment
G	0007010	biological_process	cytoskeleton organization
G	0007155	biological_process	cell adhesion
G	0007229	biological_process	integrin-mediated signaling pathway
G	0008180	cellular_component	COP9 signalosome
G	0008360	biological_process	regulation of cell shape
G	0009898	cellular_component	cytoplasmic side of plasma membrane
G	0009986	cellular_component	cell surface
G	0015031	biological_process	protein transport
G	0015629	cellular_component	actin cytoskeleton
G	0016020	cellular_component	membrane
G	0016459	cellular_component	myosin complex
G	0016460	cellular_component	myosin II complex
G	0019904	molecular_function	protein domain specific binding
G	0030029	biological_process	actin filament-based process
G	0030036	biological_process	actin cytoskeleton organization
G	0030048	biological_process	actin filament-based movement
G	0030154	biological_process	cell differentiation
G	0030220	biological_process	platelet formation
G	0030224	biological_process	monocyte differentiation
G	0030863	cellular_component	cortical cytoskeleton
G	0031032	biological_process	actomyosin structure organization
G	0031252	cellular_component	cell leading edge
G	0031410	cellular_component	cytoplasmic vesicle
G	0031594	cellular_component	neuromuscular junction
G	0032154	cellular_component	cleavage furrow
G	0032418	biological_process	lysosome localization
G	0032506	biological_process	cytokinetic process
G	0032970	biological_process	regulation of actin filament-based process
G	0032982	cellular_component	myosin filament
G	0032991	cellular_component	protein-containing complex
G	0042641	cellular_component	actomyosin
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043495	molecular_function	protein-membrane adaptor activity
G	0043531	molecular_function	ADP binding
G	0043534	biological_process	blood vessel endothelial cell migration
G	0045055	biological_process	regulated exocytosis
G	0045296	molecular_function	cadherin binding
G	0046718	biological_process	symbiont entry into host cell
G	0050900	biological_process	leukocyte migration
G	0051015	molecular_function	actin filament binding
G	0060471	biological_process	cortical granule exocytosis
G	0060473	cellular_component	cortical granule
G	0070062	cellular_component	extracellular exosome
G	0070527	biological_process	platelet aggregation
G	0097513	cellular_component	myosin II filament
G	0099512	cellular_component	supramolecular fiber
G	1903919	biological_process	negative regulation of actin filament severing
G	1903923	biological_process	positive regulation of protein processing in phagocytic vesicle
G	1905684	biological_process	regulation of plasma membrane repair
H	0000146	molecular_function	microfilament motor activity
H	0000166	molecular_function	nucleotide binding
H	0000902	biological_process	cell morphogenesis
H	0001525	biological_process	angiogenesis
H	0001618	molecular_function	virus receptor activity
H	0001725	cellular_component	stress fiber
H	0001726	cellular_component	ruffle
H	0001772	cellular_component	immunological synapse
H	0001778	biological_process	plasma membrane repair
H	0001931	cellular_component	uropod
H	0003723	molecular_function	RNA binding
H	0003774	molecular_function	cytoskeletal motor activity
H	0003779	molecular_function	actin binding
H	0005178	molecular_function	integrin binding
H	0005515	molecular_function	protein binding
H	0005516	molecular_function	calmodulin binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005794	cellular_component	Golgi apparatus
H	0005819	cellular_component	spindle
H	0005826	cellular_component	actomyosin contractile ring
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0005903	cellular_component	brush border
H	0005912	cellular_component	adherens junction
H	0005925	cellular_component	focal adhesion
H	0005938	cellular_component	cell cortex
H	0006509	biological_process	membrane protein ectodomain proteolysis
H	0006911	biological_process	phagocytosis, engulfment
H	0007010	biological_process	cytoskeleton organization
H	0007155	biological_process	cell adhesion
H	0007229	biological_process	integrin-mediated signaling pathway
H	0008180	cellular_component	COP9 signalosome
H	0008360	biological_process	regulation of cell shape
H	0009898	cellular_component	cytoplasmic side of plasma membrane
H	0009986	cellular_component	cell surface
H	0015031	biological_process	protein transport
H	0015629	cellular_component	actin cytoskeleton
H	0016020	cellular_component	membrane
H	0016459	cellular_component	myosin complex
H	0016460	cellular_component	myosin II complex
H	0019904	molecular_function	protein domain specific binding
H	0030029	biological_process	actin filament-based process
H	0030036	biological_process	actin cytoskeleton organization
H	0030048	biological_process	actin filament-based movement
H	0030154	biological_process	cell differentiation
H	0030220	biological_process	platelet formation
H	0030224	biological_process	monocyte differentiation
H	0030863	cellular_component	cortical cytoskeleton
H	0031032	biological_process	actomyosin structure organization
H	0031252	cellular_component	cell leading edge
H	0031410	cellular_component	cytoplasmic vesicle
H	0031594	cellular_component	neuromuscular junction
H	0032154	cellular_component	cleavage furrow
H	0032418	biological_process	lysosome localization
H	0032506	biological_process	cytokinetic process
H	0032970	biological_process	regulation of actin filament-based process
H	0032982	cellular_component	myosin filament
H	0032991	cellular_component	protein-containing complex
H	0042641	cellular_component	actomyosin
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0043495	molecular_function	protein-membrane adaptor activity
H	0043531	molecular_function	ADP binding
H	0043534	biological_process	blood vessel endothelial cell migration
H	0045055	biological_process	regulated exocytosis
H	0045296	molecular_function	cadherin binding
H	0046718	biological_process	symbiont entry into host cell
H	0050900	biological_process	leukocyte migration
H	0051015	molecular_function	actin filament binding
H	0060471	biological_process	cortical granule exocytosis
H	0060473	cellular_component	cortical granule
H	0070062	cellular_component	extracellular exosome
H	0070527	biological_process	platelet aggregation
H	0097513	cellular_component	myosin II filament
H	0099512	cellular_component	supramolecular fiber
H	1903919	biological_process	negative regulation of actin filament severing
H	1903923	biological_process	positive regulation of protein processing in phagocytic vesicle
H	1905684	biological_process	regulation of plasma membrane repair

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DQNRDGFIDkeDL

Chain	Residue	Details
E	ASP41-LEU53

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	Domain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	58
Details	Domain: {"description":"IQ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	44
Details	Region: {"description":"Actin-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Claeys R."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P35580","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDD5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDD5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	64
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"N-acetylcysteine","evidences":[{"source":"PubMed","id":"6870825","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by MLCK, CIT and ROCK2","evidences":[{"source":"UniProtKB","id":"P24844","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CDC42BP, CIT, MLCK, PAK1, ROCK1, ROCK2, DAPK1, DAPK2 and ZIPK/DAPK3","evidences":[{"source":"UniProtKB","id":"P24844","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---