9SWN

Cryo-EM structure of yeast telomerase holoenzyme

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000333	cellular_component	telomerase catalytic core complex
A	0000781	cellular_component	chromosome, telomeric region
A	0003720	molecular_function	telomerase activity
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005697	cellular_component	telomerase holoenzyme complex
A	0005730	cellular_component	nucleolus
A	0007004	biological_process	telomere maintenance via telomerase
A	0034061	molecular_function	DNA polymerase activity
A	0042162	molecular_function	telomeric repeat DNA binding
A	0070034	molecular_function	telomerase RNA binding
C	0000723	biological_process	telomere maintenance
C	0000781	cellular_component	chromosome, telomeric region
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005697	cellular_component	telomerase holoenzyme complex
C	0005829	cellular_component	cytosol
C	0007004	biological_process	telomere maintenance via telomerase
C	0033677	molecular_function	DNA/RNA helicase activity
C	0042162	molecular_function	telomeric repeat DNA binding
D	0000171	molecular_function	ribonuclease MRP activity
D	0000172	cellular_component	ribonuclease MRP complex
D	0000294	biological_process	nuclear-transcribed mRNA catabolic process, RNase MRP-dependent
D	0000447	biological_process	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D	0000460	biological_process	maturation of 5.8S rRNA
D	0001682	biological_process	tRNA 5'-leader removal
D	0003723	molecular_function	RNA binding
D	0004526	molecular_function	ribonuclease P activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005655	cellular_component	nucleolar ribonuclease P complex
D	0005697	cellular_component	telomerase holoenzyme complex
D	0005737	cellular_component	cytoplasm
D	0006364	biological_process	rRNA processing
D	0008033	biological_process	tRNA processing
D	0034965	biological_process	intronic box C/D snoRNA processing
E	0000171	molecular_function	ribonuclease MRP activity
E	0000172	cellular_component	ribonuclease MRP complex
E	0000294	biological_process	nuclear-transcribed mRNA catabolic process, RNase MRP-dependent
E	0000460	biological_process	maturation of 5.8S rRNA
E	0001682	biological_process	tRNA 5'-leader removal
E	0003723	molecular_function	RNA binding
E	0004526	molecular_function	ribonuclease P activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005655	cellular_component	nucleolar ribonuclease P complex
E	0005697	cellular_component	telomerase holoenzyme complex
E	0005829	cellular_component	cytosol
E	0006364	biological_process	rRNA processing
E	0008033	biological_process	tRNA processing
E	0034965	biological_process	intronic box C/D snoRNA processing
E	0042134	molecular_function	rRNA primary transcript binding
F	0000171	molecular_function	ribonuclease MRP activity
F	0000172	cellular_component	ribonuclease MRP complex
F	0000294	biological_process	nuclear-transcribed mRNA catabolic process, RNase MRP-dependent
F	0000460	biological_process	maturation of 5.8S rRNA
F	0001682	biological_process	tRNA 5'-leader removal
F	0003723	molecular_function	RNA binding
F	0004526	molecular_function	ribonuclease P activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005655	cellular_component	nucleolar ribonuclease P complex
F	0005697	cellular_component	telomerase holoenzyme complex
F	0006364	biological_process	rRNA processing
F	0008033	biological_process	tRNA processing
F	0034965	biological_process	intronic box C/D snoRNA processing
G	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
G	0000723	biological_process	telomere maintenance
G	0000781	cellular_component	chromosome, telomeric region
G	0003697	molecular_function	single-stranded DNA binding
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005697	cellular_component	telomerase holoenzyme complex
G	0005730	cellular_component	nucleolus
G	0007004	biological_process	telomere maintenance via telomerase
G	0032210	biological_process	regulation of telomere maintenance via telomerase
G	0042162	molecular_function	telomeric repeat DNA binding
G	0070034	molecular_function	telomerase RNA binding
G	0071919	biological_process	G-quadruplex DNA formation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	303
Details	Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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