9SRX
Cryo-EM structure of the Mlc repressor in complex with the glucose-specific IICB transporter
Functional Information from PROSITE/UniProt
| site_id | PS01035 |
| Number of Residues | 18 |
| Details | PTS_EIIB_TYPE_1_CYS PTS EIIB domains cysteine phosphorylation site signature. NItnldaCiTRLrVsVaD |
| Chain | Residue | Details |
| K | ASN414-ASP431 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 800 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00426","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 292 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 280 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Phosphocysteine intermediate; for EIIB activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00421","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12716891","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18319344","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"3129430","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphocysteine","evidences":[{"source":"PubMed","id":"8505292","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 36 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15929984","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18319344","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BP8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
