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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9S2F

Human debranched intron spliceosome (DIS)

This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues165
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues177
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsMotif: {"description":"DEAH box"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues491
DetailsRegion: {"description":"Reverse transcriptase homology domain"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues273
DetailsRegion: {"description":"Linker"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues13
DetailsRegion: {"description":"Important for branch point selection","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues171
DetailsRegion: {"description":"Restriction endonuclease homology domain"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues10
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues9
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues15
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues282
DetailsDomain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues14
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues157
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues156
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues160
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues154
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues156
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues159
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues101
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues19
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues32
DetailsRepeat: {"description":"HAT 2","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues32
DetailsRepeat: {"description":"HAT 3","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues34
DetailsRepeat: {"description":"HAT 4","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues32
DetailsRepeat: {"description":"HAT 5","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues67
DetailsRepeat: {"description":"HAT 6"}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues67
DetailsRepeat: {"description":"HAT 7"}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues67
DetailsRepeat: {"description":"HAT 8"}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues72
DetailsRepeat: {"description":"HAT 9"}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues68
DetailsRepeat: {"description":"HAT 10"}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues65
DetailsRepeat: {"description":"HAT 11"}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues66
DetailsRepeat: {"description":"HAT 12"}
ChainResidueDetails
site_idSWS_FT_FI38
Number of Residues68
DetailsRepeat: {"description":"HAT 13"}
ChainResidueDetails
site_idSWS_FT_FI39
Number of Residues65
DetailsRepeat: {"description":"HAT 14"}
ChainResidueDetails
site_idSWS_FT_FI40
Number of Residues32
DetailsRepeat: {"description":"HAT 1"}
ChainResidueDetails
site_idSWS_FT_FI41
Number of Residues32
DetailsRepeat: {"description":"HAT 2"}
ChainResidueDetails
site_idSWS_FT_FI42
Number of Residues32
DetailsRepeat: {"description":"HAT 3"}
ChainResidueDetails
site_idSWS_FT_FI43
Number of Residues31
DetailsRepeat: {"description":"HAT 4"}
ChainResidueDetails
site_idSWS_FT_FI44
Number of Residues31
DetailsRepeat: {"description":"HAT 5"}
ChainResidueDetails
site_idSWS_FT_FI45
Number of Residues41
DetailsRepeat: {"description":"HAT 15"}
ChainResidueDetails
site_idSWS_FT_FI46
Number of Residues217
DetailsRegion: {"description":"Mediates interaction with HSP90","evidences":[{"source":"UniProtKB","id":"P63154","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI47
Number of Residues51
DetailsDomain: {"description":"HTH myb-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI48
Number of Residues45
DetailsDNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI49
Number of Residues94
DetailsRegion: {"description":"Interaction with PLRG1","evidences":[{"source":"PubMed","id":"11544257","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI50
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18583928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI51
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18583928","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI52
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI53
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI54
Number of Residues8
DetailsRegion: {"description":"Interaction with AR","evidences":[{"source":"PubMed","id":"28076346","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI55
Number of Residues8
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI56
Number of Residues27
DetailsZinc finger: {"description":"C3H1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00723","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI57
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI58
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI59
Number of Residues332
DetailsDomain: {"description":"UPF1-type SF1B helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01433","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI60
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25599396","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PJ3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI61
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01433","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25599396","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PJ3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI62
Number of Residues20
DetailsRegion: {"description":"Interaction with PPIL1","evidences":[{"source":"PubMed","id":"16595688","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI63
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Dozynkiewicz M.","Norman J.C."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI64
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI65
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI66
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI67
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI68
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI69
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI70
Number of Residues154
DetailsDomain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI71
Number of Residues23
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16595688","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI72
Number of Residues27
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI73
Number of Residues290
DetailsDomain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI74
Number of Residues1
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI75
Number of Residues2
DetailsModified residue: {"description":"Omega-N-methylarginine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI76
Number of Residues79
DetailsRegion: {"description":"Sufficient for interaction with CLNS1A","evidences":[{"source":"PubMed","id":"11747828","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI77
Number of Residues1
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}
ChainResidueDetails
site_idSWS_FT_FI78
Number of Residues2
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2010","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI79
Number of Residues71
DetailsDomain: {"description":"U-box"}
ChainResidueDetails

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PDB entries from 2026-07-29

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