9RTX

Mammalian AP3 complex on tubular membranes (ARF1 centered Beta3-ARF1 dimer-Beta3 interface)

Functional Information from GO Data

Chain	GOid	namespace	contents
d	0000139	cellular_component	Golgi membrane
d	0005737	cellular_component	cytoplasm
d	0005794	cellular_component	Golgi apparatus
d	0006886	biological_process	intracellular protein transport
d	0007041	biological_process	lysosomal transport
d	0010008	cellular_component	endosome membrane
d	0010496	biological_process	intercellular transport
d	0016050	biological_process	vesicle organization
D	0000139	cellular_component	Golgi membrane
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0006886	biological_process	intracellular protein transport
D	0007041	biological_process	lysosomal transport
D	0010008	cellular_component	endosome membrane
D	0010496	biological_process	intercellular transport
D	0016050	biological_process	vesicle organization
E	0000139	cellular_component	Golgi membrane
E	0000287	molecular_function	magnesium ion binding
E	0002090	biological_process	regulation of receptor internalization
E	0003723	molecular_function	RNA binding
E	0003924	molecular_function	GTPase activity
E	0003925	molecular_function	G protein activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005765	cellular_component	lysosomal membrane
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006878	biological_process	intracellular copper ion homeostasis
E	0006886	biological_process	intracellular protein transport
E	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
E	0012505	cellular_component	endomembrane system
E	0014069	cellular_component	postsynaptic density
E	0016192	biological_process	vesicle-mediated transport
E	0019904	molecular_function	protein domain specific binding
E	0030017	cellular_component	sarcomere
E	0031252	cellular_component	cell leading edge
E	0032991	cellular_component	protein-containing complex
E	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
E	0035964	biological_process	COPI-coated vesicle budding
E	0045202	cellular_component	synapse
E	0046836	biological_process	glycolipid transport
E	0060292	biological_process	long-term synaptic depression
E	0070062	cellular_component	extracellular exosome
E	0097061	biological_process	dendritic spine organization
E	0098586	biological_process	cellular response to virus
E	0160281	cellular_component	cytoplasmic side of trans-Golgi network membrane
E	1903292	biological_process	protein localization to Golgi membrane
E	1990386	biological_process	mitotic cleavage furrow ingression
F	0000139	cellular_component	Golgi membrane
F	0000287	molecular_function	magnesium ion binding
F	0002090	biological_process	regulation of receptor internalization
F	0003723	molecular_function	RNA binding
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005765	cellular_component	lysosomal membrane
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006878	biological_process	intracellular copper ion homeostasis
F	0006886	biological_process	intracellular protein transport
F	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
F	0012505	cellular_component	endomembrane system
F	0014069	cellular_component	postsynaptic density
F	0016192	biological_process	vesicle-mediated transport
F	0019904	molecular_function	protein domain specific binding
F	0030017	cellular_component	sarcomere
F	0031252	cellular_component	cell leading edge
F	0032991	cellular_component	protein-containing complex
F	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
F	0035964	biological_process	COPI-coated vesicle budding
F	0045202	cellular_component	synapse
F	0046836	biological_process	glycolipid transport
F	0060292	biological_process	long-term synaptic depression
F	0070062	cellular_component	extracellular exosome
F	0097061	biological_process	dendritic spine organization
F	0098586	biological_process	cellular response to virus
F	0160281	cellular_component	cytoplasmic side of trans-Golgi network membrane
F	1903292	biological_process	protein localization to Golgi membrane
F	1990386	biological_process	mitotic cleavage furrow ingression
G	0000139	cellular_component	Golgi membrane
G	0000287	molecular_function	magnesium ion binding
G	0002090	biological_process	regulation of receptor internalization
G	0003723	molecular_function	RNA binding
G	0003924	molecular_function	GTPase activity
G	0003925	molecular_function	G protein activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005765	cellular_component	lysosomal membrane
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006878	biological_process	intracellular copper ion homeostasis
G	0006886	biological_process	intracellular protein transport
G	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
G	0012505	cellular_component	endomembrane system
G	0014069	cellular_component	postsynaptic density
G	0016192	biological_process	vesicle-mediated transport
G	0019904	molecular_function	protein domain specific binding
G	0030017	cellular_component	sarcomere
G	0031252	cellular_component	cell leading edge
G	0032991	cellular_component	protein-containing complex
G	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
G	0035964	biological_process	COPI-coated vesicle budding
G	0045202	cellular_component	synapse
G	0046836	biological_process	glycolipid transport
G	0060292	biological_process	long-term synaptic depression
G	0070062	cellular_component	extracellular exosome
G	0097061	biological_process	dendritic spine organization
G	0098586	biological_process	cellular response to virus
G	0160281	cellular_component	cytoplasmic side of trans-Golgi network membrane
G	1903292	biological_process	protein localization to Golgi membrane
G	1990386	biological_process	mitotic cleavage furrow ingression
H	0000139	cellular_component	Golgi membrane
H	0000287	molecular_function	magnesium ion binding
H	0002090	biological_process	regulation of receptor internalization
H	0003723	molecular_function	RNA binding
H	0003924	molecular_function	GTPase activity
H	0003925	molecular_function	G protein activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005765	cellular_component	lysosomal membrane
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006878	biological_process	intracellular copper ion homeostasis
H	0006886	biological_process	intracellular protein transport
H	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
H	0012505	cellular_component	endomembrane system
H	0014069	cellular_component	postsynaptic density
H	0016192	biological_process	vesicle-mediated transport
H	0019904	molecular_function	protein domain specific binding
H	0030017	cellular_component	sarcomere
H	0031252	cellular_component	cell leading edge
H	0032991	cellular_component	protein-containing complex
H	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
H	0035964	biological_process	COPI-coated vesicle budding
H	0045202	cellular_component	synapse
H	0046836	biological_process	glycolipid transport
H	0060292	biological_process	long-term synaptic depression
H	0070062	cellular_component	extracellular exosome
H	0097061	biological_process	dendritic spine organization
H	0098586	biological_process	cellular response to virus
H	0160281	cellular_component	cytoplasmic side of trans-Golgi network membrane
H	1903292	biological_process	protein localization to Golgi membrane
H	1990386	biological_process	mitotic cleavage furrow ingression
I	0000139	cellular_component	Golgi membrane
I	0000287	molecular_function	magnesium ion binding
I	0002090	biological_process	regulation of receptor internalization
I	0003723	molecular_function	RNA binding
I	0003924	molecular_function	GTPase activity
I	0003925	molecular_function	G protein activity
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005765	cellular_component	lysosomal membrane
I	0005794	cellular_component	Golgi apparatus
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0005925	cellular_component	focal adhesion
I	0006878	biological_process	intracellular copper ion homeostasis
I	0006886	biological_process	intracellular protein transport
I	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
I	0012505	cellular_component	endomembrane system
I	0014069	cellular_component	postsynaptic density
I	0016192	biological_process	vesicle-mediated transport
I	0019904	molecular_function	protein domain specific binding
I	0030017	cellular_component	sarcomere
I	0031252	cellular_component	cell leading edge
I	0032991	cellular_component	protein-containing complex
I	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
I	0035964	biological_process	COPI-coated vesicle budding
I	0045202	cellular_component	synapse
I	0046836	biological_process	glycolipid transport
I	0060292	biological_process	long-term synaptic depression
I	0070062	cellular_component	extracellular exosome
I	0097061	biological_process	dendritic spine organization
I	0098586	biological_process	cellular response to virus
I	0160281	cellular_component	cytoplasmic side of trans-Golgi network membrane
I	1903292	biological_process	protein localization to Golgi membrane
I	1990386	biological_process	mitotic cleavage furrow ingression
J	0000139	cellular_component	Golgi membrane
J	0000287	molecular_function	magnesium ion binding
J	0002090	biological_process	regulation of receptor internalization
J	0003723	molecular_function	RNA binding
J	0003924	molecular_function	GTPase activity
J	0003925	molecular_function	G protein activity
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005765	cellular_component	lysosomal membrane
J	0005794	cellular_component	Golgi apparatus
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0005925	cellular_component	focal adhesion
J	0006878	biological_process	intracellular copper ion homeostasis
J	0006886	biological_process	intracellular protein transport
J	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
J	0012505	cellular_component	endomembrane system
J	0014069	cellular_component	postsynaptic density
J	0016192	biological_process	vesicle-mediated transport
J	0019904	molecular_function	protein domain specific binding
J	0030017	cellular_component	sarcomere
J	0031252	cellular_component	cell leading edge
J	0032991	cellular_component	protein-containing complex
J	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
J	0035964	biological_process	COPI-coated vesicle budding
J	0045202	cellular_component	synapse
J	0046836	biological_process	glycolipid transport
J	0060292	biological_process	long-term synaptic depression
J	0070062	cellular_component	extracellular exosome
J	0097061	biological_process	dendritic spine organization
J	0098586	biological_process	cellular response to virus
J	0160281	cellular_component	cytoplasmic side of trans-Golgi network membrane
J	1903292	biological_process	protein localization to Golgi membrane
J	1990386	biological_process	mitotic cleavage furrow ingression
m	0005794	cellular_component	Golgi apparatus
m	0006886	biological_process	intracellular protein transport
m	0030131	cellular_component	clathrin adaptor complex
m	0030659	cellular_component	cytoplasmic vesicle membrane
M	0005794	cellular_component	Golgi apparatus
M	0006886	biological_process	intracellular protein transport
M	0030131	cellular_component	clathrin adaptor complex
M	0030659	cellular_component	cytoplasmic vesicle membrane
s	0005515	molecular_function	protein binding
s	0005769	cellular_component	early endosome
s	0005794	cellular_component	Golgi apparatus
s	0008089	biological_process	anterograde axonal transport
s	0008286	biological_process	insulin receptor signaling pathway
s	0016020	cellular_component	membrane
s	0016183	biological_process	synaptic vesicle coating
s	0016192	biological_process	vesicle-mediated transport
s	0030119	cellular_component	AP-type membrane coat adaptor complex
s	0030123	cellular_component	AP-3 adaptor complex
s	0030133	cellular_component	transport vesicle
s	0030659	cellular_component	cytoplasmic vesicle membrane
s	0035651	molecular_function	AP-3 adaptor complex binding
s	0035654	biological_process	clathrin-coated vesicle cargo loading, AP-3-mediated
s	0036465	biological_process	synaptic vesicle recycling
s	0048490	biological_process	anterograde synaptic vesicle transport
s	0060155	biological_process	platelet dense granule organization
s	0098793	cellular_component	presynapse
s	1903232	biological_process	melanosome assembly
s	1904115	cellular_component	axon cytoplasm
S	0005515	molecular_function	protein binding
S	0005769	cellular_component	early endosome
S	0005794	cellular_component	Golgi apparatus
S	0008089	biological_process	anterograde axonal transport
S	0008286	biological_process	insulin receptor signaling pathway
S	0016020	cellular_component	membrane
S	0016183	biological_process	synaptic vesicle coating
S	0016192	biological_process	vesicle-mediated transport
S	0030119	cellular_component	AP-type membrane coat adaptor complex
S	0030123	cellular_component	AP-3 adaptor complex
S	0030133	cellular_component	transport vesicle
S	0030659	cellular_component	cytoplasmic vesicle membrane
S	0035651	molecular_function	AP-3 adaptor complex binding
S	0035654	biological_process	clathrin-coated vesicle cargo loading, AP-3-mediated
S	0036465	biological_process	synaptic vesicle recycling
S	0048490	biological_process	anterograde synaptic vesicle transport
S	0060155	biological_process	platelet dense granule organization
S	0098793	cellular_component	presynapse
S	1903232	biological_process	melanosome assembly
S	1904115	cellular_component	axon cytoplasm

Functional Information from PROSITE/UniProt

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. LIYRhyatLYF

Chain	Residue	Details
s	LEU63-PHE73

---

site_id	PS00990
Number of Residues	21
Details	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IPWRra.GvkYtnNeAYFDVVE

Chain	Residue	Details
m	ILE165-GLU185

---

site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. LsFIPPdGnFrLisY

Chain	Residue	Details
m	LEU248-TYR262

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14690595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15308674","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of ARFGAP1-ARF1 fusion protein.","authoringGroup":["Structural genomics consortium (SGC)."]}},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3O47","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15308674","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of ARFGAP1-ARF1 fusion protein.","authoringGroup":["Structural genomics consortium (SGC)."]}},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3O47","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---