9RP9

Crystal structure of mouse pVHL-ElonginB-ElonginC complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000151	cellular_component	ubiquitin ligase complex
A	0001525	biological_process	angiogenesis
A	0001666	biological_process	response to hypoxia
A	0003309	biological_process	type B pancreatic cell differentiation
A	0003310	biological_process	pancreatic A cell differentiation
A	0003711	molecular_function	transcription elongation factor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006582	biological_process	melanin metabolic process
A	0008285	biological_process	negative regulation of cell population proliferation
A	0009968	biological_process	negative regulation of signal transduction
A	0010468	biological_process	regulation of gene expression
A	0010498	biological_process	proteasomal protein catabolic process
A	0010507	biological_process	negative regulation of autophagy
A	0010629	biological_process	negative regulation of gene expression
A	0014069	cellular_component	postsynaptic density
A	0015031	biological_process	protein transport
A	0015630	cellular_component	microtubule cytoskeleton
A	0016567	biological_process	protein ubiquitination
A	0019899	molecular_function	enzyme binding
A	0030163	biological_process	protein catabolic process
A	0030182	biological_process	neuron differentiation
A	0030198	biological_process	extracellular matrix organization
A	0030891	cellular_component	VCB complex
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0032880	biological_process	regulation of protein localization
A	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
A	0042069	biological_process	regulation of catecholamine metabolic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043534	biological_process	blood vessel endothelial cell migration
A	0044877	molecular_function	protein-containing complex binding
A	0045471	biological_process	response to ethanol
A	0045602	biological_process	negative regulation of endothelial cell differentiation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046426	biological_process	negative regulation of receptor signaling pathway via JAK-STAT
A	0048069	biological_process	eye pigmentation
A	0048593	biological_process	camera-type eye morphogenesis
A	0048877	biological_process	homeostasis of number of retina cells
A	0050679	biological_process	positive regulation of epithelial cell proliferation
A	0060090	molecular_function	molecular adaptor activity
A	0061072	biological_process	iris morphogenesis
A	0061073	biological_process	ciliary body morphogenesis
A	0070243	biological_process	regulation of thymocyte apoptotic process
A	0070244	biological_process	negative regulation of thymocyte apoptotic process
A	0097542	cellular_component	ciliary tip
A	0098978	cellular_component	glutamatergic synapse
A	0099175	biological_process	regulation of postsynapse organization
A	0120283	molecular_function	protein serine/threonine kinase binding
A	0140252	biological_process	regulation protein catabolic process at postsynapse
A	0140297	molecular_function	DNA-binding transcription factor binding
A	1900037	biological_process	regulation of cellular response to hypoxia
A	1902072	biological_process	negative regulation of hypoxia-inducible factor-1alpha signaling pathway
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1990000	biological_process	amyloid fibril formation
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
A	2001233	biological_process	regulation of apoptotic signaling pathway

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	78
Details	Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"Q15370","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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