9RHM

Phospho-MCM double hexamer bound to Sld3-Sld7-Cdc45 on ARS1 DNA

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0003678	molecular_function	DNA helicase activity
2	0003682	molecular_function	chromatin binding
2	0003688	molecular_function	DNA replication origin binding
2	0003697	molecular_function	single-stranded DNA binding
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005656	cellular_component	nuclear pre-replicative complex
2	0005737	cellular_component	cytoplasm
2	0006260	biological_process	DNA replication
2	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
2	0006271	biological_process	DNA strand elongation involved in DNA replication
2	0006279	biological_process	premeiotic DNA replication
2	0006974	biological_process	DNA damage response
2	0008270	molecular_function	zinc ion binding
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0031261	cellular_component	DNA replication preinitiation complex
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0043596	cellular_component	nuclear replication fork
2	0071162	cellular_component	CMG complex
2	1902975	biological_process	mitotic DNA replication initiation
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000781	cellular_component	chromosome, telomeric region
3	0003678	molecular_function	DNA helicase activity
3	0003682	molecular_function	chromatin binding
3	0003688	molecular_function	DNA replication origin binding
3	0003697	molecular_function	single-stranded DNA binding
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005656	cellular_component	nuclear pre-replicative complex
3	0005737	cellular_component	cytoplasm
3	0006260	biological_process	DNA replication
3	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006279	biological_process	premeiotic DNA replication
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030466	biological_process	silent mating-type cassette heterochromatin formation
3	0031261	cellular_component	DNA replication preinitiation complex
3	0031509	biological_process	subtelomeric heterochromatin formation
3	0042555	cellular_component	MCM complex
3	0043596	cellular_component	nuclear replication fork
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
3	1904931	molecular_function	MCM complex binding
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0003678	molecular_function	DNA helicase activity
4	0003688	molecular_function	DNA replication origin binding
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005656	cellular_component	nuclear pre-replicative complex
4	0005737	cellular_component	cytoplasm
4	0006260	biological_process	DNA replication
4	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006279	biological_process	premeiotic DNA replication
4	0008270	molecular_function	zinc ion binding
4	0009378	molecular_function	four-way junction helicase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0031261	cellular_component	DNA replication preinitiation complex
4	0033260	biological_process	nuclear DNA replication
4	0042555	cellular_component	MCM complex
4	0043138	molecular_function	3'-5' DNA helicase activity
4	0043596	cellular_component	nuclear replication fork
4	0071162	cellular_component	CMG complex
4	0097373	cellular_component	MCM core complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0000781	cellular_component	chromosome, telomeric region
5	0003678	molecular_function	DNA helicase activity
5	0003682	molecular_function	chromatin binding
5	0003688	molecular_function	DNA replication origin binding
5	0003697	molecular_function	single-stranded DNA binding
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005656	cellular_component	nuclear pre-replicative complex
5	0005737	cellular_component	cytoplasm
5	0006260	biological_process	DNA replication
5	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
5	0006270	biological_process	DNA replication initiation
5	0006279	biological_process	premeiotic DNA replication
5	0006368	biological_process	transcription elongation by RNA polymerase II
5	0008270	molecular_function	zinc ion binding
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030174	biological_process	regulation of DNA-templated DNA replication initiation
5	0031261	cellular_component	DNA replication preinitiation complex
5	0031507	biological_process	heterochromatin formation
5	0031509	biological_process	subtelomeric heterochromatin formation
5	0033260	biological_process	nuclear DNA replication
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0043596	cellular_component	nuclear replication fork
5	0071162	cellular_component	CMG complex
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0003678	molecular_function	DNA helicase activity
6	0003688	molecular_function	DNA replication origin binding
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005656	cellular_component	nuclear pre-replicative complex
6	0005737	cellular_component	cytoplasm
6	0005777	cellular_component	peroxisome
6	0006260	biological_process	DNA replication
6	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
6	0006271	biological_process	DNA strand elongation involved in DNA replication
6	0006279	biological_process	premeiotic DNA replication
6	0008270	molecular_function	zinc ion binding
6	0009378	molecular_function	four-way junction helicase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0017116	molecular_function	single-stranded DNA helicase activity
6	0031261	cellular_component	DNA replication preinitiation complex
6	0042555	cellular_component	MCM complex
6	0043138	molecular_function	3'-5' DNA helicase activity
6	0043596	cellular_component	nuclear replication fork
6	0071162	cellular_component	CMG complex
6	0097373	cellular_component	MCM core complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0000781	cellular_component	chromosome, telomeric region
7	0003678	molecular_function	DNA helicase activity
7	0003682	molecular_function	chromatin binding
7	0003688	molecular_function	DNA replication origin binding
7	0003697	molecular_function	single-stranded DNA binding
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005656	cellular_component	nuclear pre-replicative complex
7	0005737	cellular_component	cytoplasm
7	0006260	biological_process	DNA replication
7	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0006279	biological_process	premeiotic DNA replication
7	0008270	molecular_function	zinc ion binding
7	0009378	molecular_function	four-way junction helicase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0030466	biological_process	silent mating-type cassette heterochromatin formation
7	0031261	cellular_component	DNA replication preinitiation complex
7	0031509	biological_process	subtelomeric heterochromatin formation
7	0033260	biological_process	nuclear DNA replication
7	0042555	cellular_component	MCM complex
7	0043138	molecular_function	3'-5' DNA helicase activity
7	0043596	cellular_component	nuclear replication fork
7	0071162	cellular_component	CMG complex
7	0097373	cellular_component	MCM core complex
7	1904931	molecular_function	MCM complex binding
a	0000727	biological_process	double-strand break repair via break-induced replication
a	0003678	molecular_function	DNA helicase activity
a	0003682	molecular_function	chromatin binding
a	0003688	molecular_function	DNA replication origin binding
a	0003697	molecular_function	single-stranded DNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005656	cellular_component	nuclear pre-replicative complex
a	0005737	cellular_component	cytoplasm
a	0006260	biological_process	DNA replication
a	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
a	0006271	biological_process	DNA strand elongation involved in DNA replication
a	0006279	biological_process	premeiotic DNA replication
a	0006974	biological_process	DNA damage response
a	0008270	molecular_function	zinc ion binding
a	0016887	molecular_function	ATP hydrolysis activity
a	0017116	molecular_function	single-stranded DNA helicase activity
a	0031261	cellular_component	DNA replication preinitiation complex
a	0042555	cellular_component	MCM complex
a	0043138	molecular_function	3'-5' DNA helicase activity
a	0043596	cellular_component	nuclear replication fork
a	0071162	cellular_component	CMG complex
a	1902975	biological_process	mitotic DNA replication initiation
A	0000775	cellular_component	chromosome, centromeric region
A	0000922	cellular_component	spindle pole
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0031261	cellular_component	DNA replication preinitiation complex
b	0000727	biological_process	double-strand break repair via break-induced replication
b	0000781	cellular_component	chromosome, telomeric region
b	0003678	molecular_function	DNA helicase activity
b	0003682	molecular_function	chromatin binding
b	0003688	molecular_function	DNA replication origin binding
b	0003697	molecular_function	single-stranded DNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005656	cellular_component	nuclear pre-replicative complex
b	0005737	cellular_component	cytoplasm
b	0006260	biological_process	DNA replication
b	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
b	0006270	biological_process	DNA replication initiation
b	0006271	biological_process	DNA strand elongation involved in DNA replication
b	0006279	biological_process	premeiotic DNA replication
b	0016887	molecular_function	ATP hydrolysis activity
b	0017116	molecular_function	single-stranded DNA helicase activity
b	0030466	biological_process	silent mating-type cassette heterochromatin formation
b	0031261	cellular_component	DNA replication preinitiation complex
b	0031509	biological_process	subtelomeric heterochromatin formation
b	0042555	cellular_component	MCM complex
b	0043596	cellular_component	nuclear replication fork
b	0071162	cellular_component	CMG complex
b	1902975	biological_process	mitotic DNA replication initiation
b	1904931	molecular_function	MCM complex binding
c	0000727	biological_process	double-strand break repair via break-induced replication
c	0003678	molecular_function	DNA helicase activity
c	0003688	molecular_function	DNA replication origin binding
c	0003697	molecular_function	single-stranded DNA binding
c	0004386	molecular_function	helicase activity
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005656	cellular_component	nuclear pre-replicative complex
c	0005737	cellular_component	cytoplasm
c	0006260	biological_process	DNA replication
c	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
c	0006270	biological_process	DNA replication initiation
c	0006271	biological_process	DNA strand elongation involved in DNA replication
c	0006279	biological_process	premeiotic DNA replication
c	0008270	molecular_function	zinc ion binding
c	0009378	molecular_function	four-way junction helicase activity
c	0016887	molecular_function	ATP hydrolysis activity
c	0017116	molecular_function	single-stranded DNA helicase activity
c	0031261	cellular_component	DNA replication preinitiation complex
c	0033260	biological_process	nuclear DNA replication
c	0042555	cellular_component	MCM complex
c	0043138	molecular_function	3'-5' DNA helicase activity
c	0043596	cellular_component	nuclear replication fork
c	0071162	cellular_component	CMG complex
c	0097373	cellular_component	MCM core complex
c	1902975	biological_process	mitotic DNA replication initiation
d	0000727	biological_process	double-strand break repair via break-induced replication
d	0000781	cellular_component	chromosome, telomeric region
d	0003678	molecular_function	DNA helicase activity
d	0003682	molecular_function	chromatin binding
d	0003688	molecular_function	DNA replication origin binding
d	0003697	molecular_function	single-stranded DNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005656	cellular_component	nuclear pre-replicative complex
d	0005737	cellular_component	cytoplasm
d	0006260	biological_process	DNA replication
d	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
d	0006270	biological_process	DNA replication initiation
d	0006279	biological_process	premeiotic DNA replication
d	0006368	biological_process	transcription elongation by RNA polymerase II
d	0008270	molecular_function	zinc ion binding
d	0016887	molecular_function	ATP hydrolysis activity
d	0017116	molecular_function	single-stranded DNA helicase activity
d	0030174	biological_process	regulation of DNA-templated DNA replication initiation
d	0031261	cellular_component	DNA replication preinitiation complex
d	0031507	biological_process	heterochromatin formation
d	0031509	biological_process	subtelomeric heterochromatin formation
d	0033260	biological_process	nuclear DNA replication
d	0042555	cellular_component	MCM complex
d	0043138	molecular_function	3'-5' DNA helicase activity
d	0043596	cellular_component	nuclear replication fork
d	0071162	cellular_component	CMG complex
e	0000727	biological_process	double-strand break repair via break-induced replication
e	0003678	molecular_function	DNA helicase activity
e	0003688	molecular_function	DNA replication origin binding
e	0003697	molecular_function	single-stranded DNA binding
e	0004386	molecular_function	helicase activity
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005656	cellular_component	nuclear pre-replicative complex
e	0005737	cellular_component	cytoplasm
e	0005777	cellular_component	peroxisome
e	0006260	biological_process	DNA replication
e	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
e	0006271	biological_process	DNA strand elongation involved in DNA replication
e	0006279	biological_process	premeiotic DNA replication
e	0008270	molecular_function	zinc ion binding
e	0009378	molecular_function	four-way junction helicase activity
e	0016887	molecular_function	ATP hydrolysis activity
e	0017116	molecular_function	single-stranded DNA helicase activity
e	0031261	cellular_component	DNA replication preinitiation complex
e	0042555	cellular_component	MCM complex
e	0043138	molecular_function	3'-5' DNA helicase activity
e	0043596	cellular_component	nuclear replication fork
e	0071162	cellular_component	CMG complex
e	0097373	cellular_component	MCM core complex
e	1902969	biological_process	mitotic DNA replication
e	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
f	0000727	biological_process	double-strand break repair via break-induced replication
f	0000781	cellular_component	chromosome, telomeric region
f	0003678	molecular_function	DNA helicase activity
f	0003682	molecular_function	chromatin binding
f	0003688	molecular_function	DNA replication origin binding
f	0003697	molecular_function	single-stranded DNA binding
f	0005515	molecular_function	protein binding
f	0005524	molecular_function	ATP binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005656	cellular_component	nuclear pre-replicative complex
f	0005737	cellular_component	cytoplasm
f	0006260	biological_process	DNA replication
f	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
f	0006270	biological_process	DNA replication initiation
f	0006271	biological_process	DNA strand elongation involved in DNA replication
f	0006279	biological_process	premeiotic DNA replication
f	0008270	molecular_function	zinc ion binding
f	0009378	molecular_function	four-way junction helicase activity
f	0016887	molecular_function	ATP hydrolysis activity
f	0017116	molecular_function	single-stranded DNA helicase activity
f	0030466	biological_process	silent mating-type cassette heterochromatin formation
f	0031261	cellular_component	DNA replication preinitiation complex
f	0031509	biological_process	subtelomeric heterochromatin formation
f	0033260	biological_process	nuclear DNA replication
f	0042555	cellular_component	MCM complex
f	0043138	molecular_function	3'-5' DNA helicase activity
f	0043596	cellular_component	nuclear replication fork
f	0071162	cellular_component	CMG complex
f	0097373	cellular_component	MCM core complex
f	1904931	molecular_function	MCM complex binding
H	0000727	biological_process	double-strand break repair via break-induced replication
H	0000775	cellular_component	chromosome, centromeric region
H	0000785	cellular_component	chromatin
H	0003682	molecular_function	chromatin binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0006260	biological_process	DNA replication
H	0006270	biological_process	DNA replication initiation
H	0031261	cellular_component	DNA replication preinitiation complex
H	0033314	biological_process	mitotic DNA replication checkpoint signaling
H	1903466	biological_process	regulation of mitotic DNA replication initiation
I	0000727	biological_process	double-strand break repair via break-induced replication
I	0000775	cellular_component	chromosome, centromeric region
I	0000785	cellular_component	chromatin
I	0003682	molecular_function	chromatin binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0006260	biological_process	DNA replication
I	0006270	biological_process	DNA replication initiation
I	0031261	cellular_component	DNA replication preinitiation complex
I	0033314	biological_process	mitotic DNA replication checkpoint signaling
I	1903466	biological_process	regulation of mitotic DNA replication initiation
R	0000775	cellular_component	chromosome, centromeric region
R	0000922	cellular_component	spindle pole
R	0003674	molecular_function	molecular_function
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005635	cellular_component	nuclear envelope
R	0005737	cellular_component	cytoplasm
R	0005783	cellular_component	endoplasmic reticulum
R	0030174	biological_process	regulation of DNA-templated DNA replication initiation
R	0031261	cellular_component	DNA replication preinitiation complex

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVVCIDEFD

Chain	Residue	Details
5	GLY475-ASP483
4	GLY627-ASP635
7	GLY519-ASP527
2	GLY602-ASP610
3	GLY468-ASP476

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	52
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	84
Details	Motif: {"description":"Walker A","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Motif: {"description":"Walker B","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	70
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Site: {"description":"Arginine finger","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	690
Details	Domain: {"description":"MCM C-terminal AAA(+) ATPase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P33993","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---