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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9RDK

Cryo-EM structure of the human SAGA co-activator complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000124cellular_componentSAGA complex
A0000375biological_processRNA splicing, via transesterification reactions
A0000387biological_processspliceosomal snRNP assembly
A0000388biological_processspliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
A0000398biological_processmRNA splicing, via spliceosome
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005681cellular_componentspliceosomal complex
A0005684cellular_componentU2-type spliceosomal complex
A0005686cellular_componentU2 snRNP
A0005689cellular_componentU12-type spliceosomal complex
A0005730cellular_componentnucleolus
A0006282biological_processregulation of DNA repair
A0008380biological_processRNA splicing
A0030620molecular_functionU2 snRNA binding
A0034693cellular_componentU11/U12 snRNP
A0042177biological_processnegative regulation of protein catabolic process
A0043484biological_processregulation of RNA splicing
A0044877molecular_functionprotein-containing complex binding
A0045893biological_processpositive regulation of DNA-templated transcription
A0071005cellular_componentU2-type precatalytic spliceosome
A0071006cellular_componentU2-type catalytic step 1 spliceosome
A0071011cellular_componentprecatalytic spliceosome
A0071013cellular_componentcatalytic step 2 spliceosome
A0071016cellular_componentU12-type precatalytic spliceosome
A0071018cellular_componentU12-type catalytic step 2 spliceosome
A1903241biological_processU2-type prespliceosome assembly
B0000124cellular_componentSAGA complex
B0000387biological_processspliceosomal snRNP assembly
B0000388biological_processspliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B0000398biological_processmRNA splicing, via spliceosome
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005681cellular_componentspliceosomal complex
B0005684cellular_componentU2-type spliceosomal complex
B0005686cellular_componentU2 snRNP
B0005689cellular_componentU12-type spliceosomal complex
B0006282biological_processregulation of DNA repair
B0034693cellular_componentU11/U12 snRNP
B0043484biological_processregulation of RNA splicing
B0045893biological_processpositive regulation of DNA-templated transcription
B0071005cellular_componentU2-type precatalytic spliceosome
B0071006cellular_componentU2-type catalytic step 1 spliceosome
B0071011cellular_componentprecatalytic spliceosome
B0071016cellular_componentU12-type precatalytic spliceosome
B0071018cellular_componentU12-type catalytic step 2 spliceosome
B1903241biological_processU2-type prespliceosome assembly
B1990935molecular_functionsplicing factor binding
C0000124cellular_componentSAGA complex
C0000786cellular_componentnucleosome
C0000812cellular_componentSwr1 complex
C0003712molecular_functiontranscription coregulator activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0006282biological_processregulation of DNA repair
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0016301molecular_functionkinase activity
C0033276cellular_componenttranscription factor TFTC complex
C0035267cellular_componentNuA4 histone acetyltransferase complex
C0042981biological_processregulation of apoptotic process
C0043484biological_processregulation of RNA splicing
C0045893biological_processpositive regulation of DNA-templated transcription
C0051726biological_processregulation of cell cycle
C0080135biological_processregulation of cellular response to stress
C0140861biological_processDNA repair-dependent chromatin remodeling
C1905168biological_processpositive regulation of double-strand break repair via homologous recombination
C2000779biological_processregulation of double-strand break repair
D0000124cellular_componentSAGA complex
D0003713molecular_functiontranscription coactivator activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0006282biological_processregulation of DNA repair
D0043484biological_processregulation of RNA splicing
D0045893biological_processpositive regulation of DNA-templated transcription
D0051457biological_processmaintenance of protein location in nucleus
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0003714molecular_functiontranscription corepressor activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005669cellular_componenttranscription factor TFIID complex
E0006366biological_processtranscription by RNA polymerase II
E0016251molecular_functionRNA polymerase II general transcription initiation factor activity
E0030307biological_processpositive regulation of cell growth
E0033276cellular_componenttranscription factor TFTC complex
E0043066biological_processnegative regulation of apoptotic process
E0050821biological_processprotein stabilization
E1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
G0000124cellular_componentSAGA complex
G0003677molecular_functionDNA binding
G0003713molecular_functiontranscription coactivator activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005669cellular_componenttranscription factor TFIID complex
G0006282biological_processregulation of DNA repair
G0006352biological_processDNA-templated transcription initiation
G0006355biological_processregulation of DNA-templated transcription
G0006357biological_processregulation of transcription by RNA polymerase II
G0006366biological_processtranscription by RNA polymerase II
G0006367biological_processtranscription initiation at RNA polymerase II promoter
G0016251molecular_functionRNA polymerase II general transcription initiation factor activity
G0017025molecular_functionTBP-class protein binding
G0033276cellular_componenttranscription factor TFTC complex
G0042789biological_processmRNA transcription by RNA polymerase II
G0043484biological_processregulation of RNA splicing
G0045893biological_processpositive regulation of DNA-templated transcription
G0045944biological_processpositive regulation of transcription by RNA polymerase II
G0051123biological_processRNA polymerase II preinitiation complex assembly
G0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
G0140297molecular_functionDNA-binding transcription factor binding
H0000124cellular_componentSAGA complex
H0001701biological_processin utero embryonic development
H0001756biological_processsomitogenesis
H0001892biological_processembryonic placenta development
H0003677molecular_functionDNA binding
H0004402molecular_functionhistone acetyltransferase activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005669cellular_componenttranscription factor TFIID complex
H0005737cellular_componentcytoplasm
H0006282biological_processregulation of DNA repair
H0006338biological_processchromatin remodeling
H0006352biological_processDNA-templated transcription initiation
H0006355biological_processregulation of DNA-templated transcription
H0006357biological_processregulation of transcription by RNA polymerase II
H0006366biological_processtranscription by RNA polymerase II
H0006367biological_processtranscription initiation at RNA polymerase II promoter
H0010467biological_processgene expression
H0016251molecular_functionRNA polymerase II general transcription initiation factor activity
H0019899molecular_functionenzyme binding
H0030331molecular_functionnuclear estrogen receptor binding
H0033276cellular_componenttranscription factor TFTC complex
H0036285biological_processSAGA complex assembly
H0042789biological_processmRNA transcription by RNA polymerase II
H0042802molecular_functionidentical protein binding
H0043484biological_processregulation of RNA splicing
H0045893biological_processpositive regulation of DNA-templated transcription
H0048371biological_processlateral mesodermal cell differentiation
H0048471cellular_componentperinuclear region of cytoplasm
H0051123biological_processRNA polymerase II preinitiation complex assembly
H0060173biological_processlimb development
H0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
H0070063molecular_functionRNA polymerase binding
H0097550cellular_componenttranscription preinitiation complex
H1905069biological_processallantois development
H1990841molecular_functionpromoter-specific chromatin binding
I0000124cellular_componentSAGA complex
I0003713molecular_functiontranscription coactivator activity
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0006282biological_processregulation of DNA repair
I0006355biological_processregulation of DNA-templated transcription
I0006357biological_processregulation of transcription by RNA polymerase II
I0006366biological_processtranscription by RNA polymerase II
I0033276cellular_componenttranscription factor TFTC complex
I0043484biological_processregulation of RNA splicing
I0045893biological_processpositive regulation of DNA-templated transcription
J0000124cellular_componentSAGA complex
J0003713molecular_functiontranscription coactivator activity
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0006282biological_processregulation of DNA repair
J0006357biological_processregulation of transcription by RNA polymerase II
J0043484biological_processregulation of RNA splicing
J0045893biological_processpositive regulation of DNA-templated transcription
K0000118cellular_componenthistone deacetylase complex
K0000124cellular_componentSAGA complex
K0003677molecular_functionDNA binding
K0003713molecular_functiontranscription coactivator activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0006282biological_processregulation of DNA repair
K0006338biological_processchromatin remodeling
K0006355biological_processregulation of DNA-templated transcription
K0006357biological_processregulation of transcription by RNA polymerase II
K0043484biological_processregulation of RNA splicing
K0045893biological_processpositive regulation of DNA-templated transcription
K0051123biological_processRNA polymerase II preinitiation complex assembly
K0070062cellular_componentextracellular exosome
K1904672biological_processregulation of somatic stem cell population maintenance
L0000124cellular_componentSAGA complex
L0003713molecular_functiontranscription coactivator activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0006282biological_processregulation of DNA repair
L0006355biological_processregulation of DNA-templated transcription
L0006357biological_processregulation of transcription by RNA polymerase II
L0006366biological_processtranscription by RNA polymerase II
L0016607cellular_componentnuclear speck
L0033276cellular_componenttranscription factor TFTC complex
L0043484biological_processregulation of RNA splicing
L0045893biological_processpositive regulation of DNA-templated transcription
L1904672biological_processregulation of somatic stem cell population maintenance
M0000124cellular_componentSAGA complex
M0003712molecular_functiontranscription coregulator activity
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0006282biological_processregulation of DNA repair
M0006357biological_processregulation of transcription by RNA polymerase II
M0043484biological_processregulation of RNA splicing
M0045893biological_processpositive regulation of DNA-templated transcription
M0070461cellular_componentSAGA-type complex
N0000124cellular_componentSAGA complex
N0000226biological_processmicrotubule cytoskeleton organization
N0003682molecular_functionchromatin binding
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005730cellular_componentnucleolus
N0005737cellular_componentcytoplasm
N0005829cellular_componentcytosol
N0005856cellular_componentcytoskeleton
N0006282biological_processregulation of DNA repair
N0006357biological_processregulation of transcription by RNA polymerase II
N0006997biological_processnucleus organization
N0007026biological_processnegative regulation of microtubule depolymerization
N0007601biological_processvisual perception
N0015630cellular_componentmicrotubule cytoskeleton
N0016363cellular_componentnuclear matrix
N0033276cellular_componenttranscription factor TFTC complex
N0043484biological_processregulation of RNA splicing
N0045893biological_processpositive regulation of DNA-templated transcription
N0045944biological_processpositive regulation of transcription by RNA polymerase II
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH
ChainResidueDetails
APHE287-HIS293
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LASAgeDqRLKLWDL
ChainResidueDetails
LLEU483-LEU497
LILE525-ILE539
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues39
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues39
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues39
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues39
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues39
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues37
DetailsRegion: {"description":"Interaction with PHF5A, SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues56
DetailsRegion: {"description":"Interaction with SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues21
DetailsRegion: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues23
DetailsRegion: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues5
DetailsSite: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsSite: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues32
DetailsDomain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues6
DetailsRegion: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues8
DetailsRegion: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues25
DetailsRegion: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues67
DetailsDomain: {"description":"Histone-fold","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsModified residue: {"description":"N6,N6,N6-trimethyllysine; alternate","evidences":[{"source":"PubMed","id":"15099517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16415881","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25959397","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q7TT00","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2026-05-27

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