Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9RAI

Structure of the S.aureus MecA/ClpC/ClpP degradation system

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000166	molecular_function	nucleotide binding
a	0005524	molecular_function	ATP binding
a	0006457	biological_process	protein folding
a	0044183	molecular_function	protein folding chaperone
a	1990169	biological_process	stress response to copper ion
a	1990170	biological_process	stress response to cadmium ion
A	0030674	molecular_function	protein-macromolecule adaptor activity
b	0000166	molecular_function	nucleotide binding
b	0005524	molecular_function	ATP binding
b	0006457	biological_process	protein folding
b	0044183	molecular_function	protein folding chaperone
b	1990169	biological_process	stress response to copper ion
b	1990170	biological_process	stress response to cadmium ion
B	0030674	molecular_function	protein-macromolecule adaptor activity
c	0000166	molecular_function	nucleotide binding
c	0005524	molecular_function	ATP binding
c	0006457	biological_process	protein folding
c	0044183	molecular_function	protein folding chaperone
c	1990169	biological_process	stress response to copper ion
c	1990170	biological_process	stress response to cadmium ion
C	0030674	molecular_function	protein-macromolecule adaptor activity
d	0000166	molecular_function	nucleotide binding
d	0005524	molecular_function	ATP binding
d	0006457	biological_process	protein folding
d	0044183	molecular_function	protein folding chaperone
d	1990169	biological_process	stress response to copper ion
d	1990170	biological_process	stress response to cadmium ion
D	0030674	molecular_function	protein-macromolecule adaptor activity
e	0000166	molecular_function	nucleotide binding
e	0005524	molecular_function	ATP binding
e	0006457	biological_process	protein folding
e	0044183	molecular_function	protein folding chaperone
e	1990169	biological_process	stress response to copper ion
e	1990170	biological_process	stress response to cadmium ion
E	0030674	molecular_function	protein-macromolecule adaptor activity
f	0000166	molecular_function	nucleotide binding
f	0005524	molecular_function	ATP binding
f	0006457	biological_process	protein folding
f	0044183	molecular_function	protein folding chaperone
f	1990169	biological_process	stress response to copper ion
f	1990170	biological_process	stress response to cadmium ion
F	0030674	molecular_function	protein-macromolecule adaptor activity
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0016787	molecular_function	hydrolase activity
G	0042802	molecular_function	identical protein binding
G	0051117	molecular_function	ATPase binding
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008233	molecular_function	peptidase activity
H	0008236	molecular_function	serine-type peptidase activity
H	0009368	cellular_component	endopeptidase Clp complex
H	0016787	molecular_function	hydrolase activity
H	0042802	molecular_function	identical protein binding
H	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0016787	molecular_function	hydrolase activity
I	0042802	molecular_function	identical protein binding
I	0051117	molecular_function	ATPase binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008233	molecular_function	peptidase activity
J	0008236	molecular_function	serine-type peptidase activity
J	0009368	cellular_component	endopeptidase Clp complex
J	0016787	molecular_function	hydrolase activity
J	0042802	molecular_function	identical protein binding
J	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0016787	molecular_function	hydrolase activity
K	0042802	molecular_function	identical protein binding
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008233	molecular_function	peptidase activity
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0016787	molecular_function	hydrolase activity
L	0042802	molecular_function	identical protein binding
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008233	molecular_function	peptidase activity
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0016787	molecular_function	hydrolase activity
M	0042802	molecular_function	identical protein binding
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008233	molecular_function	peptidase activity
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0016787	molecular_function	hydrolase activity
N	0042802	molecular_function	identical protein binding
N	0051117	molecular_function	ATPase binding
O	0004176	molecular_function	ATP-dependent peptidase activity
O	0004252	molecular_function	serine-type endopeptidase activity
O	0005737	cellular_component	cytoplasm
O	0006508	biological_process	proteolysis
O	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
O	0008233	molecular_function	peptidase activity
O	0008236	molecular_function	serine-type peptidase activity
O	0009368	cellular_component	endopeptidase Clp complex
O	0016787	molecular_function	hydrolase activity
O	0042802	molecular_function	identical protein binding
O	0051117	molecular_function	ATPase binding
P	0004176	molecular_function	ATP-dependent peptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0005737	cellular_component	cytoplasm
P	0006508	biological_process	proteolysis
P	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
P	0008233	molecular_function	peptidase activity
P	0008236	molecular_function	serine-type peptidase activity
P	0009368	cellular_component	endopeptidase Clp complex
P	0016787	molecular_function	hydrolase activity
P	0042802	molecular_function	identical protein binding
P	0051117	molecular_function	ATPase binding
Q	0004176	molecular_function	ATP-dependent peptidase activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0005737	cellular_component	cytoplasm
Q	0006508	biological_process	proteolysis
Q	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Q	0008233	molecular_function	peptidase activity
Q	0008236	molecular_function	serine-type peptidase activity
Q	0009368	cellular_component	endopeptidase Clp complex
Q	0016787	molecular_function	hydrolase activity
Q	0042802	molecular_function	identical protein binding
Q	0051117	molecular_function	ATPase binding
R	0004176	molecular_function	ATP-dependent peptidase activity
R	0004252	molecular_function	serine-type endopeptidase activity
R	0005737	cellular_component	cytoplasm
R	0006508	biological_process	proteolysis
R	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
R	0008233	molecular_function	peptidase activity
R	0008236	molecular_function	serine-type peptidase activity
R	0009368	cellular_component	endopeptidase Clp complex
R	0016787	molecular_function	hydrolase activity
R	0042802	molecular_function	identical protein binding
R	0051117	molecular_function	ATPase binding
T	0004176	molecular_function	ATP-dependent peptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0005737	cellular_component	cytoplasm
T	0006508	biological_process	proteolysis
T	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
T	0008233	molecular_function	peptidase activity
T	0008236	molecular_function	serine-type peptidase activity
T	0009368	cellular_component	endopeptidase Clp complex
T	0016787	molecular_function	hydrolase activity
T	0042802	molecular_function	identical protein binding
T	0051117	molecular_function	ATPase binding
U	0004176	molecular_function	ATP-dependent peptidase activity
U	0004252	molecular_function	serine-type endopeptidase activity
U	0005737	cellular_component	cytoplasm
U	0006508	biological_process	proteolysis
U	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
U	0008233	molecular_function	peptidase activity
U	0008236	molecular_function	serine-type peptidase activity
U	0009368	cellular_component	endopeptidase Clp complex
U	0016787	molecular_function	hydrolase activity
U	0042802	molecular_function	identical protein binding
U	0051117	molecular_function	ATPase binding

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TicIGmAASMGS

Chain	Residue	Details
U	THR90-SER101

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfalPnaeVMIHQP

Chain	Residue	Details
U	ARG112-PRO125

site_id	PS00870
Number of Residues	13
Details	CLPAB_1 Chaperonins clpA/B signature 1. DASNILKPaLarG

Chain	Residue	Details
a	ASP295-GLY307

site_id	PS00871
Number of Residues	19
Details	CLPAB_2 Chaperonins clpA/B signature 2. RVDmSEFmEKhAvSRLvGA

Chain	Residue	Details
a	ARG571-ALA589

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	210
Details	Domain: {"description":"UVR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00217","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	384
Details	Region: {"description":"Repeat 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01251","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	84
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	764
Details	Region: {"description":"II"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	14
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	14
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)