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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9R8O

Primed-state RyR1 in 0.05% POPC micelles, in complex with a nanobody and FKBP

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0008144molecular_functionobsolete drug binding
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0014802cellular_componentterminal cisterna
B0016529cellular_componentsarcoplasmic reticulum
B0016853molecular_functionisomerase activity
B0033017cellular_componentsarcoplasmic reticulum membrane
B0043231cellular_componentintracellular membrane-bounded organelle
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0000166molecular_functionnucleotide binding
C0003151biological_processoutflow tract morphogenesis
C0005219molecular_functionryanodine-sensitive calcium-release channel activity
C0005245molecular_functionvoltage-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005790cellular_componentsmooth endoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006936biological_processmuscle contraction
C0006941biological_processstriated muscle contraction
C0008144molecular_functionobsolete drug binding
C0014802cellular_componentterminal cisterna
C0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0015278molecular_functionintracellularly gated calcium channel activity
C0015643molecular_functiontoxic substance binding
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0030018cellular_componentZ disc
C0031090cellular_componentorganelle membrane
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034704cellular_componentcalcium channel complex
C0035381molecular_functionATP-gated ion channel activity
C0042383cellular_componentsarcolemma
C0042802molecular_functionidentical protein binding
C0043588biological_processskin development
C0043931biological_processossification involved in bone maturation
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0048741biological_processskeletal muscle fiber development
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0070588biological_processcalcium ion transmembrane transport
C0071277biological_processcellular response to calcium ion
C0071313biological_processcellular response to caffeine
C0097718molecular_functiondisordered domain specific binding
C1990425cellular_componentryanodine receptor complex
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0008144molecular_functionobsolete drug binding
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0014802cellular_componentterminal cisterna
E0016529cellular_componentsarcoplasmic reticulum
E0016853molecular_functionisomerase activity
E0033017cellular_componentsarcoplasmic reticulum membrane
E0043231cellular_componentintracellular membrane-bounded organelle
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0000166molecular_functionnucleotide binding
F0003151biological_processoutflow tract morphogenesis
F0005219molecular_functionryanodine-sensitive calcium-release channel activity
F0005245molecular_functionvoltage-gated calcium channel activity
F0005262molecular_functioncalcium channel activity
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005516molecular_functioncalmodulin binding
F0005524molecular_functionATP binding
F0005790cellular_componentsmooth endoplasmic reticulum
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0006816biological_processcalcium ion transport
F0006936biological_processmuscle contraction
F0006941biological_processstriated muscle contraction
F0008144molecular_functionobsolete drug binding
F0014802cellular_componentterminal cisterna
F0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0015278molecular_functionintracellularly gated calcium channel activity
F0015643molecular_functiontoxic substance binding
F0016020cellular_componentmembrane
F0016529cellular_componentsarcoplasmic reticulum
F0019722biological_processcalcium-mediated signaling
F0030018cellular_componentZ disc
F0031090cellular_componentorganelle membrane
F0033017cellular_componentsarcoplasmic reticulum membrane
F0034220biological_processmonoatomic ion transmembrane transport
F0034704cellular_componentcalcium channel complex
F0035381molecular_functionATP-gated ion channel activity
F0042383cellular_componentsarcolemma
F0042802molecular_functionidentical protein binding
F0043588biological_processskin development
F0043931biological_processossification involved in bone maturation
F0044325molecular_functiontransmembrane transporter binding
F0046872molecular_functionmetal ion binding
F0048741biological_processskeletal muscle fiber development
F0051209biological_processrelease of sequestered calcium ion into cytosol
F0051289biological_processprotein homotetramerization
F0070588biological_processcalcium ion transmembrane transport
F0071277biological_processcellular response to calcium ion
F0071313biological_processcellular response to caffeine
F0097718molecular_functiondisordered domain specific binding
F1990425cellular_componentryanodine receptor complex
H0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0008144molecular_functionobsolete drug binding
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0014802cellular_componentterminal cisterna
H0016529cellular_componentsarcoplasmic reticulum
H0016853molecular_functionisomerase activity
H0033017cellular_componentsarcoplasmic reticulum membrane
H0043231cellular_componentintracellular membrane-bounded organelle
H0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
I0000166molecular_functionnucleotide binding
I0003151biological_processoutflow tract morphogenesis
I0005219molecular_functionryanodine-sensitive calcium-release channel activity
I0005245molecular_functionvoltage-gated calcium channel activity
I0005262molecular_functioncalcium channel activity
I0005509molecular_functioncalcium ion binding
I0005515molecular_functionprotein binding
I0005516molecular_functioncalmodulin binding
I0005524molecular_functionATP binding
I0005790cellular_componentsmooth endoplasmic reticulum
I0005886cellular_componentplasma membrane
I0006811biological_processmonoatomic ion transport
I0006816biological_processcalcium ion transport
I0006936biological_processmuscle contraction
I0006941biological_processstriated muscle contraction
I0008144molecular_functionobsolete drug binding
I0014802cellular_componentterminal cisterna
I0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0015278molecular_functionintracellularly gated calcium channel activity
I0015643molecular_functiontoxic substance binding
I0016020cellular_componentmembrane
I0016529cellular_componentsarcoplasmic reticulum
I0019722biological_processcalcium-mediated signaling
I0030018cellular_componentZ disc
I0031090cellular_componentorganelle membrane
I0033017cellular_componentsarcoplasmic reticulum membrane
I0034220biological_processmonoatomic ion transmembrane transport
I0034704cellular_componentcalcium channel complex
I0035381molecular_functionATP-gated ion channel activity
I0042383cellular_componentsarcolemma
I0042802molecular_functionidentical protein binding
I0043588biological_processskin development
I0043931biological_processossification involved in bone maturation
I0044325molecular_functiontransmembrane transporter binding
I0046872molecular_functionmetal ion binding
I0048741biological_processskeletal muscle fiber development
I0051209biological_processrelease of sequestered calcium ion into cytosol
I0051289biological_processprotein homotetramerization
I0070588biological_processcalcium ion transmembrane transport
I0071277biological_processcellular response to calcium ion
I0071313biological_processcellular response to caffeine
I0097718molecular_functiondisordered domain specific binding
I1990425cellular_componentryanodine receptor complex
J0000166molecular_functionnucleotide binding
J0003151biological_processoutflow tract morphogenesis
J0005219molecular_functionryanodine-sensitive calcium-release channel activity
J0005245molecular_functionvoltage-gated calcium channel activity
J0005262molecular_functioncalcium channel activity
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005516molecular_functioncalmodulin binding
J0005524molecular_functionATP binding
J0005790cellular_componentsmooth endoplasmic reticulum
J0005886cellular_componentplasma membrane
J0006811biological_processmonoatomic ion transport
J0006816biological_processcalcium ion transport
J0006936biological_processmuscle contraction
J0006941biological_processstriated muscle contraction
J0008144molecular_functionobsolete drug binding
J0014802cellular_componentterminal cisterna
J0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0015278molecular_functionintracellularly gated calcium channel activity
J0015643molecular_functiontoxic substance binding
J0016020cellular_componentmembrane
J0016529cellular_componentsarcoplasmic reticulum
J0019722biological_processcalcium-mediated signaling
J0030018cellular_componentZ disc
J0031090cellular_componentorganelle membrane
J0033017cellular_componentsarcoplasmic reticulum membrane
J0034220biological_processmonoatomic ion transmembrane transport
J0034704cellular_componentcalcium channel complex
J0035381molecular_functionATP-gated ion channel activity
J0042383cellular_componentsarcolemma
J0042802molecular_functionidentical protein binding
J0043588biological_processskin development
J0043931biological_processossification involved in bone maturation
J0044325molecular_functiontransmembrane transporter binding
J0046872molecular_functionmetal ion binding
J0048741biological_processskeletal muscle fiber development
J0051209biological_processrelease of sequestered calcium ion into cytosol
J0051289biological_processprotein homotetramerization
J0070588biological_processcalcium ion transmembrane transport
J0071277biological_processcellular response to calcium ion
J0071313biological_processcellular response to caffeine
J0097718molecular_functiondisordered domain specific binding
J1990425cellular_componentryanodine receptor complex
L0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0008144molecular_functionobsolete drug binding
L0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L0014802cellular_componentterminal cisterna
L0016529cellular_componentsarcoplasmic reticulum
L0016853molecular_functionisomerase activity
L0033017cellular_componentsarcoplasmic reticulum membrane
L0043231cellular_componentintracellular membrane-bounded organelle
L0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues352
DetailsDomain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues908
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues168
DetailsTopological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues64
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues76
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues220
DetailsDomain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues180
DetailsDomain: {"description":"MIR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues216
DetailsDomain: {"description":"MIR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues864
DetailsDomain: {"description":"B30.2/SPRY 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00548","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues452
DetailsRepeat: {"description":"1"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues112
DetailsDomain: {"description":"EF-hand","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues44
DetailsRegion: {"description":"Interaction with FKBP1A","evidences":[{"source":"PubMed","id":"26245150","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues24
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5TA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues60
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5T9V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5TAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"F1LMY4","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P21817","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P21817","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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