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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9R5N

FKBP12 in complex with binfunctional ligand b3c and the first bromodomain of BRD4

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
C0003007biological_processheart morphogenesis
C0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
C0005160molecular_functiontransforming growth factor beta receptor binding
C0005246molecular_functioncalcium channel regulator activity
C0005515molecular_functionprotein binding
C0005527molecular_functionmacrolide binding
C0005528molecular_functionFK506 binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006457biological_processprotein folding
C0006458biological_process'de novo' protein folding
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0014802cellular_componentterminal cisterna
C0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0030018cellular_componentZ disc
C0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
C0030547molecular_functionsignaling receptor inhibitor activity
C0032880biological_processregulation of protein localization
C0032926biological_processnegative regulation of activin receptor signaling pathway
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034713molecular_functiontype I transforming growth factor beta receptor binding
C0042026biological_processprotein refolding
C0042110biological_processT cell activation
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0044325molecular_functiontransmembrane transporter binding
C0050776biological_processregulation of immune response
C0051604biological_processprotein maturation
C0055010biological_processventricular cardiac muscle tissue morphogenesis
C0060347biological_processheart trabecula formation
C0070411molecular_functionI-SMAD binding
C0070697molecular_functionactivin receptor binding
C0097435biological_processsupramolecular fiber organization
C0098562cellular_componentcytoplasmic side of membrane
C1902991biological_processregulation of amyloid precursor protein catabolic process
C1990000biological_processamyloid fibril formation
C1990425cellular_componentryanodine receptor complex
D0003007biological_processheart morphogenesis
D0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
D0005160molecular_functiontransforming growth factor beta receptor binding
D0005246molecular_functioncalcium channel regulator activity
D0005515molecular_functionprotein binding
D0005527molecular_functionmacrolide binding
D0005528molecular_functionFK506 binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006457biological_processprotein folding
D0006458biological_process'de novo' protein folding
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0014802cellular_componentterminal cisterna
D0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0030018cellular_componentZ disc
D0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
D0030547molecular_functionsignaling receptor inhibitor activity
D0032880biological_processregulation of protein localization
D0032926biological_processnegative regulation of activin receptor signaling pathway
D0033017cellular_componentsarcoplasmic reticulum membrane
D0034713molecular_functiontype I transforming growth factor beta receptor binding
D0042026biological_processprotein refolding
D0042110biological_processT cell activation
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0044325molecular_functiontransmembrane transporter binding
D0050776biological_processregulation of immune response
D0051604biological_processprotein maturation
D0055010biological_processventricular cardiac muscle tissue morphogenesis
D0060347biological_processheart trabecula formation
D0070411molecular_functionI-SMAD binding
D0070697molecular_functionactivin receptor binding
D0097435biological_processsupramolecular fiber organization
D0098562cellular_componentcytoplasmic side of membrane
D1902991biological_processregulation of amyloid precursor protein catabolic process
D1990000biological_processamyloid fibril formation
D1990425cellular_componentryanodine receptor complex
Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA38-TYR97
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues176
DetailsDomain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P26883","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails
CTYR26electrostatic destabiliser, steric role
CPHE36electrostatic destabiliser, polar/non-polar interaction, steric role
CASP37electrostatic stabiliser, steric role
CILE56electrostatic stabiliser, steric role
CTYR82electrostatic stabiliser, steric role
CPHE99electrostatic destabiliser, polar/non-polar interaction, steric role
site_idMCSA2
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails
DTYR26electrostatic destabiliser, steric role
DPHE36electrostatic destabiliser, polar/non-polar interaction, steric role
DASP37electrostatic stabiliser, steric role
DILE56electrostatic stabiliser, steric role
DTYR82electrostatic stabiliser, steric role
DPHE99electrostatic destabiliser, polar/non-polar interaction, steric role

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PDB entries from 2026-06-17

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