9R3I

Structure of liver pyruvate kinase in complex with fluorescent probe 4c

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004743	molecular_function	pyruvate kinase activity
A	0006096	biological_process	glycolytic process
A	0030955	molecular_function	potassium ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004743	molecular_function	pyruvate kinase activity
B	0006096	biological_process	glycolytic process
B	0030955	molecular_function	potassium ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004743	molecular_function	pyruvate kinase activity
C	0006096	biological_process	glycolytic process
C	0030955	molecular_function	potassium ion binding
D	0000287	molecular_function	magnesium ion binding
D	0004743	molecular_function	pyruvate kinase activity
D	0006096	biological_process	glycolytic process
D	0030955	molecular_function	potassium ion binding

Functional Information from PROSITE/UniProt

site_id	PS00110
Number of Residues	13
Details	PYRUVATE_KINASE Pyruvate kinase active site signature. IkIISKIENhEGV

Chain	Residue	Details
A	ILE277-VAL289

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11960989","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VGB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	80
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11960989","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VGF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P00549","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---