9QUB
Cryo-EM structure of the human NHA2-Fab complex
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| C | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 418 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| B | MET1-ARG86 | |
| A | LEU134-PRO144 | |
| A | LEU190-LEU200 | |
| A | ALA243-LEU270 | |
| A | GLN325-ARG339 | |
| A | ALA374-ALA390 | |
| A | CYS441-ALA461 | |
| A | GLY510-VAL537 | |
| B | LEU134-PRO144 | |
| B | LEU190-LEU200 | |
| B | ALA243-LEU270 | |
| B | GLN325-ARG339 | |
| B | ALA374-ALA390 | |
| B | CYS441-ALA461 | |
| B | GLY510-VAL537 | |
| A | MET1-ARG86 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | VAL87-ILE104 | |
| A | VAL87-ILE104 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 102 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| B | THR105-GLY113 | |
| A | GLY228-TRP233 | |
| A | GLY291-VAL300 | |
| A | GLY358-GLY361 | |
| A | SER412-THR417 | |
| A | THR474-TYR486 | |
| B | ILE162-LYS171 | |
| B | GLY228-TRP233 | |
| B | GLY291-VAL300 | |
| B | GLY358-GLY361 | |
| B | SER412-THR417 | |
| B | THR474-TYR486 | |
| A | THR105-GLY113 | |
| A | ILE162-LYS171 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | ASN114-GLY133 | |
| A | ASN114-GLY133 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | SER145-VAL161 | |
| A | SER145-VAL161 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | TRP172-GLY189 | |
| A | TRP172-GLY189 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | LYS201-LEU227 | |
| A | LYS201-LEU227 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | GLY234-GLY242 | |
| A | GLY234-GLY242 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | LEU271-LEU290 | |
| A | LEU271-LEU290 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | PHE301-ILE324 | |
| A | PHE301-ILE324 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | THR340-PHE357 | |
| A | THR340-PHE357 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | SER362-LEU373 | |
| A | SER362-LEU373 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | VAL391-ALA411 | |
| A | VAL391-ALA411 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | VAL418-VAL440 | |
| A | VAL418-VAL440 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=13 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | THR462-ASP473 | |
| A | THR462-ASP473 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=14 => ECO:0000250|UniProtKB:A0A6P3HVI0 |
| Chain | Residue | Details |
| B | GLY487-ILE509 | |
| A | GLY487-ILE509 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|Ref.12, ECO:0000312|PDB:7B4L |
| Chain | Residue | Details |
| B | VAL244 | |
| B | GLY275 | |
| B | ASP278 | |
| B | ASP279 | |
| A | VAL244 | |
| A | GLY275 | |
| A | ASP278 | |
| A | ASP279 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER49 | |
| A | SER49 |
