9QEE

Cryo-EM structure of a DNA-bound XPF-ERCC1-SLX4(330-555)-SLX4IP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000109	cellular_component	nucleotide-excision repair complex
A	0000110	cellular_component	nucleotide-excision repair factor 1 complex
A	0000712	biological_process	resolution of meiotic recombination intermediates
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000781	cellular_component	chromosome, telomeric region
A	0001094	molecular_function	TFIID-class transcription factor complex binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0004520	molecular_function	DNA endonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006312	biological_process	mitotic recombination
A	0009411	biological_process	response to UV
A	0010521	molecular_function	telomerase inhibitor activity
A	0016604	cellular_component	nuclear body
A	0032205	biological_process	negative regulation of telomere maintenance
A	0034644	biological_process	cellular response to UV
A	0042802	molecular_function	identical protein binding
A	0061819	biological_process	telomeric DNA-containing double minutes formation
A	0070522	cellular_component	ERCC4-ERCC1 complex
A	1901255	biological_process	nucleotide-excision repair involved in interstrand cross-link repair
A	1904357	biological_process	negative regulation of telomere maintenance via telomere lengthening
A	1905765	biological_process	negative regulation of protection from non-homologous end joining at telomere
A	1990599	molecular_function	3' overhang single-stranded DNA endodeoxyribonuclease activity
A	1990841	molecular_function	promoter-specific chromatin binding
B	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
B	0000109	cellular_component	nucleotide-excision repair complex
B	0000110	cellular_component	nucleotide-excision repair factor 1 complex
B	0000723	biological_process	telomere maintenance
B	0000781	cellular_component	chromosome, telomeric region
B	0001094	molecular_function	TFIID-class transcription factor complex binding
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006281	biological_process	DNA repair
B	0006289	biological_process	nucleotide-excision repair
B	0006302	biological_process	double-strand break repair
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006310	biological_process	DNA recombination
B	0006312	biological_process	mitotic recombination
B	0006979	biological_process	response to oxidative stress
B	0032204	biological_process	regulation of telomere maintenance
B	0032205	biological_process	negative regulation of telomere maintenance
B	0061819	biological_process	telomeric DNA-containing double minutes formation
B	0070522	cellular_component	ERCC4-ERCC1 complex
B	0070914	biological_process	UV-damage excision repair
B	0090656	biological_process	t-circle formation
B	1904431	biological_process	positive regulation of t-circle formation
B	1905765	biological_process	negative regulation of protection from non-homologous end joining at telomere
B	1990599	molecular_function	3' overhang single-stranded DNA endodeoxyribonuclease activity
B	1990841	molecular_function	promoter-specific chromatin binding
C	0005515	molecular_function	protein binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	Domain: {"description":"ERCC4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	21
Details	Region: {"description":"Leucine-zipper 1","evidences":[{"source":"PubMed","id":"8887684","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	28
Details	Region: {"description":"Leucine-zipper 2","evidences":[{"source":"PubMed","id":"8887684","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	68
Details	Region: {"description":"HhH2, dimerization with ERCC1","evidences":[{"source":"PubMed","id":"16076955","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9QZD4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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