9QDW

Crystal structure of human PLA2G5 in complex with a SMOL inhibitor (compound 1)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004623	molecular_function	A2-type glycerophospholipase activity
A	0005509	molecular_function	calcium ion binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0006644	biological_process	phospholipid metabolic process
A	0010518	biological_process	positive regulation of phospholipase activity
A	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
A	0019370	biological_process	leukotriene biosynthetic process
A	0032009	cellular_component	early phagosome
A	0032010	cellular_component	phagolysosome
A	0034374	biological_process	low-density lipoprotein particle remodeling
A	0034638	biological_process	phosphatidylcholine catabolic process
A	0042130	biological_process	negative regulation of T cell proliferation
A	0045335	cellular_component	phagocytic vesicle
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0050766	biological_process	positive regulation of phagocytosis
A	0055037	cellular_component	recycling endosome
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0090265	biological_process	positive regulation of immune complex clearance by monocytes and macrophages
A	0090385	biological_process	phagosome-lysosome fusion
A	1903028	biological_process	positive regulation of opsonization
A	1905036	biological_process	positive regulation of antifungal innate immune response
A	1905164	biological_process	positive regulation of phagosome maturation
B	0004623	molecular_function	A2-type glycerophospholipase activity
B	0005509	molecular_function	calcium ion binding
B	0005543	molecular_function	phospholipid binding
B	0005576	cellular_component	extracellular region
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0006644	biological_process	phospholipid metabolic process
B	0010518	biological_process	positive regulation of phospholipase activity
B	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
B	0019370	biological_process	leukotriene biosynthetic process
B	0032009	cellular_component	early phagosome
B	0032010	cellular_component	phagolysosome
B	0034374	biological_process	low-density lipoprotein particle remodeling
B	0034638	biological_process	phosphatidylcholine catabolic process
B	0042130	biological_process	negative regulation of T cell proliferation
B	0045335	cellular_component	phagocytic vesicle
B	0046470	biological_process	phosphatidylcholine metabolic process
B	0046471	biological_process	phosphatidylglycerol metabolic process
B	0050766	biological_process	positive regulation of phagocytosis
B	0055037	cellular_component	recycling endosome
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0090265	biological_process	positive regulation of immune complex clearance by monocytes and macrophages
B	0090385	biological_process	phagosome-lysosome fusion
B	1903028	biological_process	positive regulation of opsonization
B	1905036	biological_process	positive regulation of antifungal innate immune response
B	1905164	biological_process	positive regulation of phagosome maturation

Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCWaHDhC

Chain	Residue	Details
A	CYS63-CYS70

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site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. LCACDRKLvYC

Chain	Residue	Details
A	LEU107-CYS117

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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