9PUO

Neutralizing monoclonal antibody Fab fragment bound to leptin

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0001525	biological_process	angiogenesis
C	0001542	biological_process	ovulation from ovarian follicle
C	0001666	biological_process	response to hypoxia
C	0001819	biological_process	positive regulation of cytokine production
C	0001890	biological_process	placenta development
C	0001936	biological_process	regulation of endothelial cell proliferation
C	0002021	biological_process	response to dietary excess
C	0003300	biological_process	cardiac muscle hypertrophy
C	0003677	molecular_function	DNA binding
C	0005102	molecular_function	signaling receptor binding
C	0005179	molecular_function	hormone activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006112	biological_process	energy reserve metabolic process
C	0006114	biological_process	glycerol biosynthetic process
C	0006629	biological_process	lipid metabolic process
C	0006909	biological_process	phagocytosis
C	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
C	0007565	biological_process	female pregnancy
C	0007584	biological_process	response to nutrient
C	0007623	biological_process	circadian rhythm
C	0008217	biological_process	regulation of blood pressure
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008343	biological_process	adult feeding behavior
C	0009062	biological_process	fatty acid catabolic process
C	0009892	biological_process	negative regulation of metabolic process
C	0010507	biological_process	negative regulation of autophagy
C	0010888	biological_process	negative regulation of lipid storage
C	0014823	biological_process	response to activity
C	0019953	biological_process	sexual reproduction
C	0030217	biological_process	T cell differentiation
C	0031667	biological_process	response to nutrient levels
C	0032008	biological_process	positive regulation of TOR signaling
C	0032099	biological_process	negative regulation of appetite
C	0032310	biological_process	prostaglandin secretion
C	0032355	biological_process	response to estradiol
C	0032735	biological_process	positive regulation of interleukin-12 production
C	0032755	biological_process	positive regulation of interleukin-6 production
C	0032757	biological_process	positive regulation of interleukin-8 production
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0032814	biological_process	regulation of natural killer cell activation
C	0032817	biological_process	regulation of natural killer cell proliferation
C	0032868	biological_process	response to insulin
C	0033197	biological_process	response to vitamin E
C	0033210	biological_process	leptin-mediated signaling pathway
C	0033686	biological_process	positive regulation of luteinizing hormone secretion
C	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
C	0035556	biological_process	intracellular signal transduction
C	0035630	biological_process	bone mineralization involved in bone maturation
C	0038108	biological_process	negative regulation of appetite by leptin-mediated signaling pathway
C	0042102	biological_process	positive regulation of T cell proliferation
C	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
C	0042307	biological_process	positive regulation of protein import into nucleus
C	0043066	biological_process	negative regulation of apoptotic process
C	0043270	biological_process	positive regulation of monoatomic ion transport
C	0043410	biological_process	positive regulation of MAPK cascade
C	0044320	biological_process	cellular response to leptin stimulus
C	0045471	biological_process	response to ethanol
C	0045765	biological_process	regulation of angiogenesis
C	0045906	biological_process	negative regulation of vasoconstriction
C	0046325	biological_process	negative regulation of D-glucose import
C	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
C	0046628	biological_process	positive regulation of insulin receptor signaling pathway
C	0046850	biological_process	regulation of bone remodeling
C	0046881	biological_process	positive regulation of follicle-stimulating hormone secretion
C	0048639	biological_process	positive regulation of developmental growth
C	0050892	biological_process	intestinal absorption
C	0050901	biological_process	leukocyte tethering or rolling
C	0050999	biological_process	regulation of nitric-oxide synthase activity
C	0051051	biological_process	negative regulation of transport
C	0051428	molecular_function	peptide hormone receptor binding
C	0051726	biological_process	regulation of cell cycle
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0060587	biological_process	regulation of lipoprotein lipid oxidation
C	0061037	biological_process	negative regulation of cartilage development
C	0070093	biological_process	negative regulation of glucagon secretion
C	0071298	biological_process	cellular response to L-ascorbic acid
C	0071300	biological_process	cellular response to retinoic acid
C	0090335	biological_process	regulation of brown fat cell differentiation
C	0097009	biological_process	energy homeostasis
C	0097696	biological_process	cell surface receptor signaling pathway via STAT
C	0098868	biological_process	bone growth
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	1900015	biological_process	regulation of cytokine production involved in inflammatory response
C	1900745	biological_process	positive regulation of p38MAPK cascade
C	1904651	biological_process	positive regulation of fat cell apoptotic process
C	1990051	biological_process	activation of protein kinase C activity
C	1990460	molecular_function	leptin receptor binding
C	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
C	2000486	biological_process	negative regulation of glutamine transport
C	2000491	biological_process	positive regulation of hepatic stellate cell activation
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0001525	biological_process	angiogenesis
F	0001542	biological_process	ovulation from ovarian follicle
F	0001666	biological_process	response to hypoxia
F	0001819	biological_process	positive regulation of cytokine production
F	0001890	biological_process	placenta development
F	0001936	biological_process	regulation of endothelial cell proliferation
F	0002021	biological_process	response to dietary excess
F	0003300	biological_process	cardiac muscle hypertrophy
F	0003677	molecular_function	DNA binding
F	0005102	molecular_function	signaling receptor binding
F	0005179	molecular_function	hormone activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006112	biological_process	energy reserve metabolic process
F	0006114	biological_process	glycerol biosynthetic process
F	0006629	biological_process	lipid metabolic process
F	0006909	biological_process	phagocytosis
F	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
F	0007565	biological_process	female pregnancy
F	0007584	biological_process	response to nutrient
F	0007623	biological_process	circadian rhythm
F	0008217	biological_process	regulation of blood pressure
F	0008284	biological_process	positive regulation of cell population proliferation
F	0008343	biological_process	adult feeding behavior
F	0009062	biological_process	fatty acid catabolic process
F	0009892	biological_process	negative regulation of metabolic process
F	0010507	biological_process	negative regulation of autophagy
F	0010888	biological_process	negative regulation of lipid storage
F	0014823	biological_process	response to activity
F	0019953	biological_process	sexual reproduction
F	0030217	biological_process	T cell differentiation
F	0031667	biological_process	response to nutrient levels
F	0032008	biological_process	positive regulation of TOR signaling
F	0032099	biological_process	negative regulation of appetite
F	0032310	biological_process	prostaglandin secretion
F	0032355	biological_process	response to estradiol
F	0032735	biological_process	positive regulation of interleukin-12 production
F	0032755	biological_process	positive regulation of interleukin-6 production
F	0032757	biological_process	positive regulation of interleukin-8 production
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0032814	biological_process	regulation of natural killer cell activation
F	0032817	biological_process	regulation of natural killer cell proliferation
F	0032868	biological_process	response to insulin
F	0033197	biological_process	response to vitamin E
F	0033210	biological_process	leptin-mediated signaling pathway
F	0033686	biological_process	positive regulation of luteinizing hormone secretion
F	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
F	0035556	biological_process	intracellular signal transduction
F	0035630	biological_process	bone mineralization involved in bone maturation
F	0038108	biological_process	negative regulation of appetite by leptin-mediated signaling pathway
F	0042102	biological_process	positive regulation of T cell proliferation
F	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
F	0042307	biological_process	positive regulation of protein import into nucleus
F	0043066	biological_process	negative regulation of apoptotic process
F	0043270	biological_process	positive regulation of monoatomic ion transport
F	0043410	biological_process	positive regulation of MAPK cascade
F	0044320	biological_process	cellular response to leptin stimulus
F	0045471	biological_process	response to ethanol
F	0045765	biological_process	regulation of angiogenesis
F	0045906	biological_process	negative regulation of vasoconstriction
F	0046325	biological_process	negative regulation of D-glucose import
F	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
F	0046628	biological_process	positive regulation of insulin receptor signaling pathway
F	0046850	biological_process	regulation of bone remodeling
F	0046881	biological_process	positive regulation of follicle-stimulating hormone secretion
F	0048639	biological_process	positive regulation of developmental growth
F	0050892	biological_process	intestinal absorption
F	0050901	biological_process	leukocyte tethering or rolling
F	0050999	biological_process	regulation of nitric-oxide synthase activity
F	0051051	biological_process	negative regulation of transport
F	0051428	molecular_function	peptide hormone receptor binding
F	0051726	biological_process	regulation of cell cycle
F	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F	0060587	biological_process	regulation of lipoprotein lipid oxidation
F	0061037	biological_process	negative regulation of cartilage development
F	0070093	biological_process	negative regulation of glucagon secretion
F	0071298	biological_process	cellular response to L-ascorbic acid
F	0071300	biological_process	cellular response to retinoic acid
F	0090335	biological_process	regulation of brown fat cell differentiation
F	0097009	biological_process	energy homeostasis
F	0097696	biological_process	cell surface receptor signaling pathway via STAT
F	0098868	biological_process	bone growth
F	0120162	biological_process	positive regulation of cold-induced thermogenesis
F	1900015	biological_process	regulation of cytokine production involved in inflammatory response
F	1900745	biological_process	positive regulation of p38MAPK cascade
F	1904651	biological_process	positive regulation of fat cell apoptotic process
F	1990051	biological_process	activation of protein kinase C activity
F	1990460	molecular_function	leptin receptor binding
F	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
F	2000486	biological_process	negative regulation of glutamine transport
F	2000491	biological_process	positive regulation of hepatic stellate cell activation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
A	TYR203-HIS209
B	TYR196-HIS202

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