9PTU

Cryo-EM structure of the DCAF11 E3 ligase bound to the DDX18 helicase mediated by GSH-M12

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0016567	biological_process	protein ubiquitination
A	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
A	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
A	0080135	biological_process	regulation of cellular response to stress
A	1902412	biological_process	regulation of mitotic cytokinesis

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VIDEADRiL

Chain	Residue	Details
C	VAL331-LEU339

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Repeat: {"description":"WD 1"}

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site_id	SWS_FT_FI2
Number of Residues	42
Details	Repeat: {"description":"WD 2"}

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site_id	SWS_FT_FI3
Number of Residues	39
Details	Repeat: {"description":"WD 3"}

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site_id	SWS_FT_FI4
Number of Residues	40
Details	Repeat: {"description":"WD 4"}

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site_id	SWS_FT_FI5
Number of Residues	39
Details	Repeat: {"description":"WD 5"}

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site_id	SWS_FT_FI6
Number of Residues	45
Details	Repeat: {"description":"WD 6"}

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site_id	SWS_FT_FI7
Number of Residues	343
Details	Region: {"description":"WD repeat beta-propeller A"}

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site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

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site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

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site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI11
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

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