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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9PTU

Cryo-EM structure of the DCAF11 E3 ligase bound to the DDX18 helicase mediated by GSH-M12

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0016567biological_processprotein ubiquitination
A0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
A0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
A0080135biological_processregulation of cellular response to stress
A1902412biological_processregulation of mitotic cytokinesis
Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VIDEADRiL
ChainResidueDetails
CVAL331-LEU339
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues42
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues39
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues40
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues39
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues45
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues46
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues45
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues51
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues52
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues44
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues52
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues46
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues60
DetailsRepeat: {"description":"WD 17","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues39
DetailsRepeat: {"description":"WD 18","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues42
DetailsRepeat: {"description":"WD 19","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues342
DetailsRegion: {"description":"WD40 beta-propeller A"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2026-10-07

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