9PRW
Cryo-EM structure of human DNMT3A/3L
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000792 | cellular_component | heterochromatin |
| B | 0000794 | cellular_component | condensed nuclear chromosome |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006346 | biological_process | DNA methylation-dependent constitutive heterochromatin formation |
| B | 0007141 | biological_process | male meiosis I |
| B | 0007283 | biological_process | spermatogenesis |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0010468 | biological_process | regulation of gene expression |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0035098 | cellular_component | ESC/E(Z) complex |
| B | 0045814 | biological_process | negative regulation of gene expression, epigenetic |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0048863 | biological_process | stem cell differentiation |
| B | 0071514 | biological_process | genomic imprinting |
| B | 0090310 | biological_process | negative regulation of DNA methylation-dependent heterochromatin formation |
| B | 0141005 | biological_process | transposable element silencing by heterochromatin formation |
| B | 0141196 | biological_process | transposable element silencing by piRNA-mediated DNA methylation |
| B | 1902494 | cellular_component | catalytic complex |
| C | 0000792 | cellular_component | heterochromatin |
| C | 0000794 | cellular_component | condensed nuclear chromosome |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006346 | biological_process | DNA methylation-dependent constitutive heterochromatin formation |
| C | 0007141 | biological_process | male meiosis I |
| C | 0007283 | biological_process | spermatogenesis |
| C | 0008047 | molecular_function | enzyme activator activity |
| C | 0010468 | biological_process | regulation of gene expression |
| C | 0019899 | molecular_function | enzyme binding |
| C | 0035098 | cellular_component | ESC/E(Z) complex |
| C | 0045814 | biological_process | negative regulation of gene expression, epigenetic |
| C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| C | 0048863 | biological_process | stem cell differentiation |
| C | 0071514 | biological_process | genomic imprinting |
| C | 0090310 | biological_process | negative regulation of DNA methylation-dependent heterochromatin formation |
| C | 0141005 | biological_process | transposable element silencing by heterochromatin formation |
| C | 0141196 | biological_process | transposable element silencing by piRNA-mediated DNA methylation |
| C | 1902494 | cellular_component | catalytic complex |
Functional Information from PROSITE/UniProt
| site_id | PS00094 |
| Number of Residues | 13 |
| Details | C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS |
| Chain | Residue | Details |
| A | ASP702-SER714 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 396 |
| Details | Domain: {"description":"ADD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00865","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 556 |
| Details | Domain: {"description":"SAM-dependent MTase C5-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 120 |
| Details | Zinc finger: {"description":"GATA-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00865","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 224 |
| Details | Zinc finger: {"description":"PHD-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00865","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 184 |
| Details | Region: {"description":"Interaction with the PRC2/EED-EZH2 complex","evidences":[{"source":"UniProtKB","id":"O88508","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10018","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17713477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QRV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-methylcysteine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"O88508","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 58 |
| Details | Domain: {"description":"PWWP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00162","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
