9PR7
Cryo-EM structure of the human inward-rectifier potassium 7.1 channel (Kir7.1) with enantiomer of 17-hydroxyprogesterone caproate
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005242 | molecular_function | inward rectifier potassium channel activity |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0030007 | biological_process | intracellular potassium ion homeostasis |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0042391 | biological_process | regulation of membrane potential |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0005242 | molecular_function | inward rectifier potassium channel activity |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0030007 | biological_process | intracellular potassium ion homeostasis |
| B | 0034702 | cellular_component | monoatomic ion channel complex |
| B | 0042391 | biological_process | regulation of membrane potential |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
| C | 0005242 | molecular_function | inward rectifier potassium channel activity |
| C | 0005267 | molecular_function | potassium channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0030007 | biological_process | intracellular potassium ion homeostasis |
| C | 0034702 | cellular_component | monoatomic ion channel complex |
| C | 0042391 | biological_process | regulation of membrane potential |
| C | 1990573 | biological_process | potassium ion import across plasma membrane |
| D | 0005242 | molecular_function | inward rectifier potassium channel activity |
| D | 0005267 | molecular_function | potassium channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0030007 | biological_process | intracellular potassium ion homeostasis |
| D | 0034702 | cellular_component | monoatomic ion channel complex |
| D | 0042391 | biological_process | regulation of membrane potential |
| D | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 104 |
| Details | Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 140 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 64 |
| Details | Intramembrane: {"description":"Helical; Pore-forming","evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 100 |
| Details | Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"18976636","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"18976636","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
