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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9PLN

Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
R0001819biological_processpositive regulation of cytokine production
R0004930molecular_functionG protein-coupled receptor activity
R0004935molecular_functionadrenergic receptor activity
R0004938molecular_functionalpha2-adrenergic receptor activity
R0005515molecular_functionprotein binding
R0005737cellular_componentcytoplasm
R0005886cellular_componentplasma membrane
R0006260biological_processDNA replication
R0007165biological_processsignal transduction
R0007173biological_processepidermal growth factor receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R0007265biological_processRas protein signal transduction
R0007266biological_processRho protein signal transduction
R0007565biological_processfemale pregnancy
R0008284biological_processpositive regulation of cell population proliferation
R0010700biological_processnegative regulation of norepinephrine secretion
R0016323cellular_componentbasolateral plasma membrane
R0019901molecular_functionprotein kinase binding
R0030036biological_processactin cytoskeleton organization
R0030335biological_processpositive regulation of cell migration
R0031692molecular_functionalpha-1B adrenergic receptor binding
R0031696molecular_functionalpha-2C adrenergic receptor binding
R0031996molecular_functionthioesterase binding
R0032795molecular_functionheterotrimeric G-protein binding
R0032811biological_processnegative regulation of epinephrine secretion
R0032870biological_processcellular response to hormone stimulus
R0042311biological_processvasodilation
R0042593biological_processglucose homeostasis
R0042803molecular_functionprotein homodimerization activity
R0043025cellular_componentneuronal cell body
R0043235cellular_componentreceptor complex
R0043268biological_processpositive regulation of potassium ion transport
R0043278biological_processresponse to morphine
R0043410biological_processpositive regulation of MAPK cascade
R0043679cellular_componentaxon terminus
R0045211cellular_componentpostsynaptic membrane
R0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
R0045955biological_processnegative regulation of calcium ion-dependent exocytosis
R0046676biological_processnegative regulation of insulin secretion
R0048787cellular_componentpresynaptic active zone membrane
R0050892biological_processintestinal absorption
R0050955biological_processthermoception
R0050995biological_processnegative regulation of lipid catabolic process
R0051044biological_processpositive regulation of membrane protein ectodomain proteolysis
R0051379molecular_functionepinephrine binding
R0051380molecular_functionnorepinephrine binding
R0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
R0051926biological_processnegative regulation of calcium ion transport
R0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
R0070473biological_processnegative regulation of uterine smooth muscle contraction
R0071875biological_processadrenergic receptor signaling pathway
R0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
R0071881biological_processadenylate cyclase-inhibiting adrenergic receptor signaling pathway
R0071882biological_processphospholipase C-activating adrenergic receptor signaling pathway
R0090303biological_processpositive regulation of wound healing
R0097305biological_processresponse to alcohol
R0098691cellular_componentdopaminergic synapse
R0098839cellular_componentpostsynaptic density membrane
R0098978cellular_componentglutamatergic synapse
R0098982cellular_componentGABA-ergic synapse
R0099171biological_processpresynaptic modulation of chemical synaptic transmission
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIvHLCAISLDRYWsI
ChainResidueDetails
RSER134-ILE150
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"35245122","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EJ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues35
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"35245122","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EJ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues19
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"35245122","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EJ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues13
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"35245122","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EJ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"35245122","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EJ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"35245122","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EJ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"35245122","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EJ0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsSite: {"description":"Implicated in norepinephrine binding","evidences":[{"source":"PubMed","id":"1678850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35245122","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsSite: {"description":"Implicated in catechol and norepinephrine agonist binding and receptor activation","evidences":[{"source":"PubMed","id":"1678850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35245122","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsSite: {"description":"Implicated in catechol agonist binding and receptor activation","evidences":[{"source":"PubMed","id":"1678850","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues3
DetailsSite: {"description":"Implicated in norepinephrine binding and receptor activation","evidences":[{"source":"PubMed","id":"35245122","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

248942

PDB entries from 2026-02-11

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