9PGO

Cryo-EM structure of brain-derived Tau fibril from Alzheimers disease patient tissue

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0001774	biological_process	microglial cell activation
A	0003677	molecular_function	DNA binding
A	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0003723	molecular_function	RNA binding
A	0003779	molecular_function	actin binding
A	0004857	molecular_function	enzyme inhibitor activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0006974	biological_process	DNA damage response
A	0007267	biological_process	cell-cell signaling
A	0007613	biological_process	memory
A	0008017	molecular_function	microtubule binding
A	0010288	biological_process	response to lead ion
A	0010506	biological_process	regulation of autophagy
A	0010629	biological_process	negative regulation of gene expression
A	0010917	biological_process	negative regulation of mitochondrial membrane potential
A	0015630	cellular_component	microtubule cytoskeleton
A	0016020	cellular_component	membrane
A	0016072	biological_process	rRNA metabolic process
A	0017124	molecular_function	SH3 domain binding
A	0019896	biological_process	axonal transport of mitochondrion
A	0019899	molecular_function	enzyme binding
A	0019901	molecular_function	protein kinase binding
A	0021954	biological_process	central nervous system neuron development
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0030426	cellular_component	growth cone
A	0030673	cellular_component	axolemma
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031110	biological_process	regulation of microtubule polymerization or depolymerization
A	0031113	biological_process	regulation of microtubule polymerization
A	0031116	biological_process	positive regulation of microtubule polymerization
A	0031122	biological_process	cytoplasmic microtubule organization
A	0031175	biological_process	neuron projection development
A	0032930	biological_process	positive regulation of superoxide anion generation
A	0033044	biological_process	regulation of chromosome organization
A	0034063	biological_process	stress granule assembly
A	0034185	molecular_function	apolipoprotein binding
A	0034399	cellular_component	nuclear periphery
A	0034452	molecular_function	dynactin binding
A	0034605	biological_process	cellular response to heat
A	0034614	biological_process	cellular response to reactive oxygen species
A	0035091	molecular_function	phosphatidylinositol binding
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0036477	cellular_component	somatodendritic compartment
A	0042802	molecular_function	identical protein binding
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043197	cellular_component	dendritic spine
A	0043565	molecular_function	sequence-specific DNA binding
A	0044297	cellular_component	cell body
A	0044304	cellular_component	main axon
A	0045121	cellular_component	membrane raft
A	0045298	cellular_component	tubulin complex
A	0045773	biological_process	positive regulation of axon extension
A	0046785	biological_process	microtubule polymerization
A	0048143	biological_process	astrocyte activation
A	0048167	biological_process	regulation of synaptic plasticity
A	0048312	biological_process	intracellular distribution of mitochondria
A	0048699	biological_process	generation of neurons
A	0050808	biological_process	synapse organization
A	0050848	biological_process	regulation of calcium-mediated signaling
A	0051087	molecular_function	protein-folding chaperone binding
A	0051258	biological_process	protein polymerization
A	0051721	molecular_function	protein phosphatase 2A binding
A	0051879	molecular_function	Hsp90 protein binding
A	0060632	biological_process	regulation of microtubule-based movement
A	0061564	biological_process	axon development
A	0070507	biological_process	regulation of microtubule cytoskeleton organization
A	0071813	molecular_function	lipoprotein particle binding
A	0072386	biological_process	plus-end-directed organelle transport along microtubule
A	0090140	biological_process	regulation of mitochondrial fission
A	0090258	biological_process	negative regulation of mitochondrial fission
A	0097386	cellular_component	glial cell projection
A	0097418	cellular_component	neurofibrillary tangle
A	0097435	biological_process	supramolecular fiber organization
A	0098930	biological_process	axonal transport
A	0099077	molecular_function	histone-dependent DNA binding
A	0099609	molecular_function	microtubule lateral binding
A	1900034	biological_process	regulation of cellular response to heat
A	1900452	biological_process	regulation of long-term synaptic depression
A	1902474	biological_process	positive regulation of protein localization to synapse
A	1902936	molecular_function	phosphatidylinositol bisphosphate binding
A	1902988	biological_process	neurofibrillary tangle assembly
A	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
A	1903829	biological_process	positive regulation of protein localization
A	1904115	cellular_component	axon cytoplasm
A	1990000	biological_process	amyloid fibril formation
A	1990090	biological_process	cellular response to nerve growth factor stimulus
A	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
B	0000226	biological_process	microtubule cytoskeleton organization
B	0001774	biological_process	microglial cell activation
B	0003677	molecular_function	DNA binding
B	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0003723	molecular_function	RNA binding
B	0003779	molecular_function	actin binding
B	0004857	molecular_function	enzyme inhibitor activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005886	cellular_component	plasma membrane
B	0006974	biological_process	DNA damage response
B	0007267	biological_process	cell-cell signaling
B	0007613	biological_process	memory
B	0008017	molecular_function	microtubule binding
B	0010288	biological_process	response to lead ion
B	0010506	biological_process	regulation of autophagy
B	0010629	biological_process	negative regulation of gene expression
B	0010917	biological_process	negative regulation of mitochondrial membrane potential
B	0015630	cellular_component	microtubule cytoskeleton
B	0016020	cellular_component	membrane
B	0016072	biological_process	rRNA metabolic process
B	0017124	molecular_function	SH3 domain binding
B	0019896	biological_process	axonal transport of mitochondrion
B	0019899	molecular_function	enzyme binding
B	0019901	molecular_function	protein kinase binding
B	0021954	biological_process	central nervous system neuron development
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0030426	cellular_component	growth cone
B	0030673	cellular_component	axolemma
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0031110	biological_process	regulation of microtubule polymerization or depolymerization
B	0031113	biological_process	regulation of microtubule polymerization
B	0031116	biological_process	positive regulation of microtubule polymerization
B	0031122	biological_process	cytoplasmic microtubule organization
B	0031175	biological_process	neuron projection development
B	0032930	biological_process	positive regulation of superoxide anion generation
B	0033044	biological_process	regulation of chromosome organization
B	0034063	biological_process	stress granule assembly
B	0034185	molecular_function	apolipoprotein binding
B	0034399	cellular_component	nuclear periphery
B	0034452	molecular_function	dynactin binding
B	0034605	biological_process	cellular response to heat
B	0034614	biological_process	cellular response to reactive oxygen species
B	0035091	molecular_function	phosphatidylinositol binding
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0036477	cellular_component	somatodendritic compartment
B	0042802	molecular_function	identical protein binding
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0043197	cellular_component	dendritic spine
B	0043565	molecular_function	sequence-specific DNA binding
B	0044297	cellular_component	cell body
B	0044304	cellular_component	main axon
B	0045121	cellular_component	membrane raft
B	0045298	cellular_component	tubulin complex
B	0045773	biological_process	positive regulation of axon extension
B	0046785	biological_process	microtubule polymerization
B	0048143	biological_process	astrocyte activation
B	0048167	biological_process	regulation of synaptic plasticity
B	0048312	biological_process	intracellular distribution of mitochondria
B	0048699	biological_process	generation of neurons
B	0050808	biological_process	synapse organization
B	0050848	biological_process	regulation of calcium-mediated signaling
B	0051087	molecular_function	protein-folding chaperone binding
B	0051258	biological_process	protein polymerization
B	0051721	molecular_function	protein phosphatase 2A binding
B	0051879	molecular_function	Hsp90 protein binding
B	0060632	biological_process	regulation of microtubule-based movement
B	0061564	biological_process	axon development
B	0070507	biological_process	regulation of microtubule cytoskeleton organization
B	0071813	molecular_function	lipoprotein particle binding
B	0072386	biological_process	plus-end-directed organelle transport along microtubule
B	0090140	biological_process	regulation of mitochondrial fission
B	0090258	biological_process	negative regulation of mitochondrial fission
B	0097386	cellular_component	glial cell projection
B	0097418	cellular_component	neurofibrillary tangle
B	0097435	biological_process	supramolecular fiber organization
B	0098930	biological_process	axonal transport
B	0099077	molecular_function	histone-dependent DNA binding
B	0099609	molecular_function	microtubule lateral binding
B	1900034	biological_process	regulation of cellular response to heat
B	1900452	biological_process	regulation of long-term synaptic depression
B	1902474	biological_process	positive regulation of protein localization to synapse
B	1902936	molecular_function	phosphatidylinositol bisphosphate binding
B	1902988	biological_process	neurofibrillary tangle assembly
B	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
B	1903829	biological_process	positive regulation of protein localization
B	1904115	cellular_component	axon cytoplasm
B	1990000	biological_process	amyloid fibril formation
B	1990090	biological_process	cellular response to nerve growth factor stimulus
B	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
C	0000226	biological_process	microtubule cytoskeleton organization
C	0001774	biological_process	microglial cell activation
C	0003677	molecular_function	DNA binding
C	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0003723	molecular_function	RNA binding
C	0003779	molecular_function	actin binding
C	0004857	molecular_function	enzyme inhibitor activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005886	cellular_component	plasma membrane
C	0006974	biological_process	DNA damage response
C	0007267	biological_process	cell-cell signaling
C	0007613	biological_process	memory
C	0008017	molecular_function	microtubule binding
C	0010288	biological_process	response to lead ion
C	0010506	biological_process	regulation of autophagy
C	0010629	biological_process	negative regulation of gene expression
C	0010917	biological_process	negative regulation of mitochondrial membrane potential
C	0015630	cellular_component	microtubule cytoskeleton
C	0016020	cellular_component	membrane
C	0016072	biological_process	rRNA metabolic process
C	0017124	molecular_function	SH3 domain binding
C	0019896	biological_process	axonal transport of mitochondrion
C	0019899	molecular_function	enzyme binding
C	0019901	molecular_function	protein kinase binding
C	0021954	biological_process	central nervous system neuron development
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0030426	cellular_component	growth cone
C	0030673	cellular_component	axolemma
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031110	biological_process	regulation of microtubule polymerization or depolymerization
C	0031113	biological_process	regulation of microtubule polymerization
C	0031116	biological_process	positive regulation of microtubule polymerization
C	0031122	biological_process	cytoplasmic microtubule organization
C	0031175	biological_process	neuron projection development
C	0032930	biological_process	positive regulation of superoxide anion generation
C	0033044	biological_process	regulation of chromosome organization
C	0034063	biological_process	stress granule assembly
C	0034185	molecular_function	apolipoprotein binding
C	0034399	cellular_component	nuclear periphery
C	0034452	molecular_function	dynactin binding
C	0034605	biological_process	cellular response to heat
C	0034614	biological_process	cellular response to reactive oxygen species
C	0035091	molecular_function	phosphatidylinositol binding
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0036477	cellular_component	somatodendritic compartment
C	0042802	molecular_function	identical protein binding
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0043197	cellular_component	dendritic spine
C	0043565	molecular_function	sequence-specific DNA binding
C	0044297	cellular_component	cell body
C	0044304	cellular_component	main axon
C	0045121	cellular_component	membrane raft
C	0045298	cellular_component	tubulin complex
C	0045773	biological_process	positive regulation of axon extension
C	0046785	biological_process	microtubule polymerization
C	0048143	biological_process	astrocyte activation
C	0048167	biological_process	regulation of synaptic plasticity
C	0048312	biological_process	intracellular distribution of mitochondria
C	0048699	biological_process	generation of neurons
C	0050808	biological_process	synapse organization
C	0050848	biological_process	regulation of calcium-mediated signaling
C	0051087	molecular_function	protein-folding chaperone binding
C	0051258	biological_process	protein polymerization
C	0051721	molecular_function	protein phosphatase 2A binding
C	0051879	molecular_function	Hsp90 protein binding
C	0060632	biological_process	regulation of microtubule-based movement
C	0061564	biological_process	axon development
C	0070507	biological_process	regulation of microtubule cytoskeleton organization
C	0071813	molecular_function	lipoprotein particle binding
C	0072386	biological_process	plus-end-directed organelle transport along microtubule
C	0090140	biological_process	regulation of mitochondrial fission
C	0090258	biological_process	negative regulation of mitochondrial fission
C	0097386	cellular_component	glial cell projection
C	0097418	cellular_component	neurofibrillary tangle
C	0097435	biological_process	supramolecular fiber organization
C	0098930	biological_process	axonal transport
C	0099077	molecular_function	histone-dependent DNA binding
C	0099609	molecular_function	microtubule lateral binding
C	1900034	biological_process	regulation of cellular response to heat
C	1900452	biological_process	regulation of long-term synaptic depression
C	1902474	biological_process	positive regulation of protein localization to synapse
C	1902936	molecular_function	phosphatidylinositol bisphosphate binding
C	1902988	biological_process	neurofibrillary tangle assembly
C	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
C	1903829	biological_process	positive regulation of protein localization
C	1904115	cellular_component	axon cytoplasm
C	1990000	biological_process	amyloid fibril formation
C	1990090	biological_process	cellular response to nerve growth factor stimulus
C	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
D	0000226	biological_process	microtubule cytoskeleton organization
D	0001774	biological_process	microglial cell activation
D	0003677	molecular_function	DNA binding
D	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
D	0003690	molecular_function	double-stranded DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0003723	molecular_function	RNA binding
D	0003779	molecular_function	actin binding
D	0004857	molecular_function	enzyme inhibitor activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0005886	cellular_component	plasma membrane
D	0006974	biological_process	DNA damage response
D	0007267	biological_process	cell-cell signaling
D	0007613	biological_process	memory
D	0008017	molecular_function	microtubule binding
D	0010288	biological_process	response to lead ion
D	0010506	biological_process	regulation of autophagy
D	0010629	biological_process	negative regulation of gene expression
D	0010917	biological_process	negative regulation of mitochondrial membrane potential
D	0015630	cellular_component	microtubule cytoskeleton
D	0016020	cellular_component	membrane
D	0016072	biological_process	rRNA metabolic process
D	0017124	molecular_function	SH3 domain binding
D	0019896	biological_process	axonal transport of mitochondrion
D	0019899	molecular_function	enzyme binding
D	0019901	molecular_function	protein kinase binding
D	0021954	biological_process	central nervous system neuron development
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0030426	cellular_component	growth cone
D	0030673	cellular_component	axolemma
D	0030674	molecular_function	protein-macromolecule adaptor activity
D	0031110	biological_process	regulation of microtubule polymerization or depolymerization
D	0031113	biological_process	regulation of microtubule polymerization
D	0031116	biological_process	positive regulation of microtubule polymerization
D	0031122	biological_process	cytoplasmic microtubule organization
D	0031175	biological_process	neuron projection development
D	0032930	biological_process	positive regulation of superoxide anion generation
D	0033044	biological_process	regulation of chromosome organization
D	0034063	biological_process	stress granule assembly
D	0034185	molecular_function	apolipoprotein binding
D	0034399	cellular_component	nuclear periphery
D	0034452	molecular_function	dynactin binding
D	0034605	biological_process	cellular response to heat
D	0034614	biological_process	cellular response to reactive oxygen species
D	0035091	molecular_function	phosphatidylinositol binding
D	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
D	0036477	cellular_component	somatodendritic compartment
D	0042802	molecular_function	identical protein binding
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0043197	cellular_component	dendritic spine
D	0043565	molecular_function	sequence-specific DNA binding
D	0044297	cellular_component	cell body
D	0044304	cellular_component	main axon
D	0045121	cellular_component	membrane raft
D	0045298	cellular_component	tubulin complex
D	0045773	biological_process	positive regulation of axon extension
D	0046785	biological_process	microtubule polymerization
D	0048143	biological_process	astrocyte activation
D	0048167	biological_process	regulation of synaptic plasticity
D	0048312	biological_process	intracellular distribution of mitochondria
D	0048699	biological_process	generation of neurons
D	0050808	biological_process	synapse organization
D	0050848	biological_process	regulation of calcium-mediated signaling
D	0051087	molecular_function	protein-folding chaperone binding
D	0051258	biological_process	protein polymerization
D	0051721	molecular_function	protein phosphatase 2A binding
D	0051879	molecular_function	Hsp90 protein binding
D	0060632	biological_process	regulation of microtubule-based movement
D	0061564	biological_process	axon development
D	0070507	biological_process	regulation of microtubule cytoskeleton organization
D	0071813	molecular_function	lipoprotein particle binding
D	0072386	biological_process	plus-end-directed organelle transport along microtubule
D	0090140	biological_process	regulation of mitochondrial fission
D	0090258	biological_process	negative regulation of mitochondrial fission
D	0097386	cellular_component	glial cell projection
D	0097418	cellular_component	neurofibrillary tangle
D	0097435	biological_process	supramolecular fiber organization
D	0098930	biological_process	axonal transport
D	0099077	molecular_function	histone-dependent DNA binding
D	0099609	molecular_function	microtubule lateral binding
D	1900034	biological_process	regulation of cellular response to heat
D	1900452	biological_process	regulation of long-term synaptic depression
D	1902474	biological_process	positive regulation of protein localization to synapse
D	1902936	molecular_function	phosphatidylinositol bisphosphate binding
D	1902988	biological_process	neurofibrillary tangle assembly
D	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
D	1903829	biological_process	positive regulation of protein localization
D	1904115	cellular_component	axon cytoplasm
D	1990000	biological_process	amyloid fibril formation
D	1990090	biological_process	cellular response to nerve growth factor stimulus
D	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
E	0000226	biological_process	microtubule cytoskeleton organization
E	0001774	biological_process	microglial cell activation
E	0003677	molecular_function	DNA binding
E	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
E	0003690	molecular_function	double-stranded DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0003723	molecular_function	RNA binding
E	0003779	molecular_function	actin binding
E	0004857	molecular_function	enzyme inhibitor activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005886	cellular_component	plasma membrane
E	0006974	biological_process	DNA damage response
E	0007267	biological_process	cell-cell signaling
E	0007613	biological_process	memory
E	0008017	molecular_function	microtubule binding
E	0010288	biological_process	response to lead ion
E	0010506	biological_process	regulation of autophagy
E	0010629	biological_process	negative regulation of gene expression
E	0010917	biological_process	negative regulation of mitochondrial membrane potential
E	0015630	cellular_component	microtubule cytoskeleton
E	0016020	cellular_component	membrane
E	0016072	biological_process	rRNA metabolic process
E	0017124	molecular_function	SH3 domain binding
E	0019896	biological_process	axonal transport of mitochondrion
E	0019899	molecular_function	enzyme binding
E	0019901	molecular_function	protein kinase binding
E	0021954	biological_process	central nervous system neuron development
E	0030424	cellular_component	axon
E	0030425	cellular_component	dendrite
E	0030426	cellular_component	growth cone
E	0030673	cellular_component	axolemma
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031110	biological_process	regulation of microtubule polymerization or depolymerization
E	0031113	biological_process	regulation of microtubule polymerization
E	0031116	biological_process	positive regulation of microtubule polymerization
E	0031122	biological_process	cytoplasmic microtubule organization
E	0031175	biological_process	neuron projection development
E	0032930	biological_process	positive regulation of superoxide anion generation
E	0033044	biological_process	regulation of chromosome organization
E	0034063	biological_process	stress granule assembly
E	0034185	molecular_function	apolipoprotein binding
E	0034399	cellular_component	nuclear periphery
E	0034452	molecular_function	dynactin binding
E	0034605	biological_process	cellular response to heat
E	0034614	biological_process	cellular response to reactive oxygen species
E	0035091	molecular_function	phosphatidylinositol binding
E	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
E	0036477	cellular_component	somatodendritic compartment
E	0042802	molecular_function	identical protein binding
E	0043005	cellular_component	neuron projection
E	0043025	cellular_component	neuronal cell body
E	0043197	cellular_component	dendritic spine
E	0043565	molecular_function	sequence-specific DNA binding
E	0044297	cellular_component	cell body
E	0044304	cellular_component	main axon
E	0045121	cellular_component	membrane raft
E	0045298	cellular_component	tubulin complex
E	0045773	biological_process	positive regulation of axon extension
E	0046785	biological_process	microtubule polymerization
E	0048143	biological_process	astrocyte activation
E	0048167	biological_process	regulation of synaptic plasticity
E	0048312	biological_process	intracellular distribution of mitochondria
E	0048699	biological_process	generation of neurons
E	0050808	biological_process	synapse organization
E	0050848	biological_process	regulation of calcium-mediated signaling
E	0051087	molecular_function	protein-folding chaperone binding
E	0051258	biological_process	protein polymerization
E	0051721	molecular_function	protein phosphatase 2A binding
E	0051879	molecular_function	Hsp90 protein binding
E	0060632	biological_process	regulation of microtubule-based movement
E	0061564	biological_process	axon development
E	0070507	biological_process	regulation of microtubule cytoskeleton organization
E	0071813	molecular_function	lipoprotein particle binding
E	0072386	biological_process	plus-end-directed organelle transport along microtubule
E	0090140	biological_process	regulation of mitochondrial fission
E	0090258	biological_process	negative regulation of mitochondrial fission
E	0097386	cellular_component	glial cell projection
E	0097418	cellular_component	neurofibrillary tangle
E	0097435	biological_process	supramolecular fiber organization
E	0098930	biological_process	axonal transport
E	0099077	molecular_function	histone-dependent DNA binding
E	0099609	molecular_function	microtubule lateral binding
E	1900034	biological_process	regulation of cellular response to heat
E	1900452	biological_process	regulation of long-term synaptic depression
E	1902474	biological_process	positive regulation of protein localization to synapse
E	1902936	molecular_function	phosphatidylinositol bisphosphate binding
E	1902988	biological_process	neurofibrillary tangle assembly
E	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
E	1903829	biological_process	positive regulation of protein localization
E	1904115	cellular_component	axon cytoplasm
E	1990000	biological_process	amyloid fibril formation
E	1990090	biological_process	cellular response to nerve growth factor stimulus
E	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
F	0000226	biological_process	microtubule cytoskeleton organization
F	0001774	biological_process	microglial cell activation
F	0003677	molecular_function	DNA binding
F	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
F	0003690	molecular_function	double-stranded DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0003723	molecular_function	RNA binding
F	0003779	molecular_function	actin binding
F	0004857	molecular_function	enzyme inhibitor activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0005886	cellular_component	plasma membrane
F	0006974	biological_process	DNA damage response
F	0007267	biological_process	cell-cell signaling
F	0007613	biological_process	memory
F	0008017	molecular_function	microtubule binding
F	0010288	biological_process	response to lead ion
F	0010506	biological_process	regulation of autophagy
F	0010629	biological_process	negative regulation of gene expression
F	0010917	biological_process	negative regulation of mitochondrial membrane potential
F	0015630	cellular_component	microtubule cytoskeleton
F	0016020	cellular_component	membrane
F	0016072	biological_process	rRNA metabolic process
F	0017124	molecular_function	SH3 domain binding
F	0019896	biological_process	axonal transport of mitochondrion
F	0019899	molecular_function	enzyme binding
F	0019901	molecular_function	protein kinase binding
F	0021954	biological_process	central nervous system neuron development
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0030426	cellular_component	growth cone
F	0030673	cellular_component	axolemma
F	0030674	molecular_function	protein-macromolecule adaptor activity
F	0031110	biological_process	regulation of microtubule polymerization or depolymerization
F	0031113	biological_process	regulation of microtubule polymerization
F	0031116	biological_process	positive regulation of microtubule polymerization
F	0031122	biological_process	cytoplasmic microtubule organization
F	0031175	biological_process	neuron projection development
F	0032930	biological_process	positive regulation of superoxide anion generation
F	0033044	biological_process	regulation of chromosome organization
F	0034063	biological_process	stress granule assembly
F	0034185	molecular_function	apolipoprotein binding
F	0034399	cellular_component	nuclear periphery
F	0034452	molecular_function	dynactin binding
F	0034605	biological_process	cellular response to heat
F	0034614	biological_process	cellular response to reactive oxygen species
F	0035091	molecular_function	phosphatidylinositol binding
F	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
F	0036477	cellular_component	somatodendritic compartment
F	0042802	molecular_function	identical protein binding
F	0043005	cellular_component	neuron projection
F	0043025	cellular_component	neuronal cell body
F	0043197	cellular_component	dendritic spine
F	0043565	molecular_function	sequence-specific DNA binding
F	0044297	cellular_component	cell body
F	0044304	cellular_component	main axon
F	0045121	cellular_component	membrane raft
F	0045298	cellular_component	tubulin complex
F	0045773	biological_process	positive regulation of axon extension
F	0046785	biological_process	microtubule polymerization
F	0048143	biological_process	astrocyte activation
F	0048167	biological_process	regulation of synaptic plasticity
F	0048312	biological_process	intracellular distribution of mitochondria
F	0048699	biological_process	generation of neurons
F	0050808	biological_process	synapse organization
F	0050848	biological_process	regulation of calcium-mediated signaling
F	0051087	molecular_function	protein-folding chaperone binding
F	0051258	biological_process	protein polymerization
F	0051721	molecular_function	protein phosphatase 2A binding
F	0051879	molecular_function	Hsp90 protein binding
F	0060632	biological_process	regulation of microtubule-based movement
F	0061564	biological_process	axon development
F	0070507	biological_process	regulation of microtubule cytoskeleton organization
F	0071813	molecular_function	lipoprotein particle binding
F	0072386	biological_process	plus-end-directed organelle transport along microtubule
F	0090140	biological_process	regulation of mitochondrial fission
F	0090258	biological_process	negative regulation of mitochondrial fission
F	0097386	cellular_component	glial cell projection
F	0097418	cellular_component	neurofibrillary tangle
F	0097435	biological_process	supramolecular fiber organization
F	0098930	biological_process	axonal transport
F	0099077	molecular_function	histone-dependent DNA binding
F	0099609	molecular_function	microtubule lateral binding
F	1900034	biological_process	regulation of cellular response to heat
F	1900452	biological_process	regulation of long-term synaptic depression
F	1902474	biological_process	positive regulation of protein localization to synapse
F	1902936	molecular_function	phosphatidylinositol bisphosphate binding
F	1902988	biological_process	neurofibrillary tangle assembly
F	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
F	1903829	biological_process	positive regulation of protein localization
F	1904115	cellular_component	axon cytoplasm
F	1990000	biological_process	amyloid fibril formation
F	1990090	biological_process	cellular response to nerve growth factor stimulus
F	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
G	0000226	biological_process	microtubule cytoskeleton organization
G	0001774	biological_process	microglial cell activation
G	0003677	molecular_function	DNA binding
G	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
G	0003690	molecular_function	double-stranded DNA binding
G	0003697	molecular_function	single-stranded DNA binding
G	0003723	molecular_function	RNA binding
G	0003779	molecular_function	actin binding
G	0004857	molecular_function	enzyme inhibitor activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005886	cellular_component	plasma membrane
G	0006974	biological_process	DNA damage response
G	0007267	biological_process	cell-cell signaling
G	0007613	biological_process	memory
G	0008017	molecular_function	microtubule binding
G	0010288	biological_process	response to lead ion
G	0010506	biological_process	regulation of autophagy
G	0010629	biological_process	negative regulation of gene expression
G	0010917	biological_process	negative regulation of mitochondrial membrane potential
G	0015630	cellular_component	microtubule cytoskeleton
G	0016020	cellular_component	membrane
G	0016072	biological_process	rRNA metabolic process
G	0017124	molecular_function	SH3 domain binding
G	0019896	biological_process	axonal transport of mitochondrion
G	0019899	molecular_function	enzyme binding
G	0019901	molecular_function	protein kinase binding
G	0021954	biological_process	central nervous system neuron development
G	0030424	cellular_component	axon
G	0030425	cellular_component	dendrite
G	0030426	cellular_component	growth cone
G	0030673	cellular_component	axolemma
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0031110	biological_process	regulation of microtubule polymerization or depolymerization
G	0031113	biological_process	regulation of microtubule polymerization
G	0031116	biological_process	positive regulation of microtubule polymerization
G	0031122	biological_process	cytoplasmic microtubule organization
G	0031175	biological_process	neuron projection development
G	0032930	biological_process	positive regulation of superoxide anion generation
G	0033044	biological_process	regulation of chromosome organization
G	0034063	biological_process	stress granule assembly
G	0034185	molecular_function	apolipoprotein binding
G	0034399	cellular_component	nuclear periphery
G	0034452	molecular_function	dynactin binding
G	0034605	biological_process	cellular response to heat
G	0034614	biological_process	cellular response to reactive oxygen species
G	0035091	molecular_function	phosphatidylinositol binding
G	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
G	0036477	cellular_component	somatodendritic compartment
G	0042802	molecular_function	identical protein binding
G	0043005	cellular_component	neuron projection
G	0043025	cellular_component	neuronal cell body
G	0043197	cellular_component	dendritic spine
G	0043565	molecular_function	sequence-specific DNA binding
G	0044297	cellular_component	cell body
G	0044304	cellular_component	main axon
G	0045121	cellular_component	membrane raft
G	0045298	cellular_component	tubulin complex
G	0045773	biological_process	positive regulation of axon extension
G	0046785	biological_process	microtubule polymerization
G	0048143	biological_process	astrocyte activation
G	0048167	biological_process	regulation of synaptic plasticity
G	0048312	biological_process	intracellular distribution of mitochondria
G	0048699	biological_process	generation of neurons
G	0050808	biological_process	synapse organization
G	0050848	biological_process	regulation of calcium-mediated signaling
G	0051087	molecular_function	protein-folding chaperone binding
G	0051258	biological_process	protein polymerization
G	0051721	molecular_function	protein phosphatase 2A binding
G	0051879	molecular_function	Hsp90 protein binding
G	0060632	biological_process	regulation of microtubule-based movement
G	0061564	biological_process	axon development
G	0070507	biological_process	regulation of microtubule cytoskeleton organization
G	0071813	molecular_function	lipoprotein particle binding
G	0072386	biological_process	plus-end-directed organelle transport along microtubule
G	0090140	biological_process	regulation of mitochondrial fission
G	0090258	biological_process	negative regulation of mitochondrial fission
G	0097386	cellular_component	glial cell projection
G	0097418	cellular_component	neurofibrillary tangle
G	0097435	biological_process	supramolecular fiber organization
G	0098930	biological_process	axonal transport
G	0099077	molecular_function	histone-dependent DNA binding
G	0099609	molecular_function	microtubule lateral binding
G	1900034	biological_process	regulation of cellular response to heat
G	1900452	biological_process	regulation of long-term synaptic depression
G	1902474	biological_process	positive regulation of protein localization to synapse
G	1902936	molecular_function	phosphatidylinositol bisphosphate binding
G	1902988	biological_process	neurofibrillary tangle assembly
G	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
G	1903829	biological_process	positive regulation of protein localization
G	1904115	cellular_component	axon cytoplasm
G	1990000	biological_process	amyloid fibril formation
G	1990090	biological_process	cellular response to nerve growth factor stimulus
G	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
H	0000226	biological_process	microtubule cytoskeleton organization
H	0001774	biological_process	microglial cell activation
H	0003677	molecular_function	DNA binding
H	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
H	0003690	molecular_function	double-stranded DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0003723	molecular_function	RNA binding
H	0003779	molecular_function	actin binding
H	0004857	molecular_function	enzyme inhibitor activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005886	cellular_component	plasma membrane
H	0006974	biological_process	DNA damage response
H	0007267	biological_process	cell-cell signaling
H	0007613	biological_process	memory
H	0008017	molecular_function	microtubule binding
H	0010288	biological_process	response to lead ion
H	0010506	biological_process	regulation of autophagy
H	0010629	biological_process	negative regulation of gene expression
H	0010917	biological_process	negative regulation of mitochondrial membrane potential
H	0015630	cellular_component	microtubule cytoskeleton
H	0016020	cellular_component	membrane
H	0016072	biological_process	rRNA metabolic process
H	0017124	molecular_function	SH3 domain binding
H	0019896	biological_process	axonal transport of mitochondrion
H	0019899	molecular_function	enzyme binding
H	0019901	molecular_function	protein kinase binding
H	0021954	biological_process	central nervous system neuron development
H	0030424	cellular_component	axon
H	0030425	cellular_component	dendrite
H	0030426	cellular_component	growth cone
H	0030673	cellular_component	axolemma
H	0030674	molecular_function	protein-macromolecule adaptor activity
H	0031110	biological_process	regulation of microtubule polymerization or depolymerization
H	0031113	biological_process	regulation of microtubule polymerization
H	0031116	biological_process	positive regulation of microtubule polymerization
H	0031122	biological_process	cytoplasmic microtubule organization
H	0031175	biological_process	neuron projection development
H	0032930	biological_process	positive regulation of superoxide anion generation
H	0033044	biological_process	regulation of chromosome organization
H	0034063	biological_process	stress granule assembly
H	0034185	molecular_function	apolipoprotein binding
H	0034399	cellular_component	nuclear periphery
H	0034452	molecular_function	dynactin binding
H	0034605	biological_process	cellular response to heat
H	0034614	biological_process	cellular response to reactive oxygen species
H	0035091	molecular_function	phosphatidylinositol binding
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0036477	cellular_component	somatodendritic compartment
H	0042802	molecular_function	identical protein binding
H	0043005	cellular_component	neuron projection
H	0043025	cellular_component	neuronal cell body
H	0043197	cellular_component	dendritic spine
H	0043565	molecular_function	sequence-specific DNA binding
H	0044297	cellular_component	cell body
H	0044304	cellular_component	main axon
H	0045121	cellular_component	membrane raft
H	0045298	cellular_component	tubulin complex
H	0045773	biological_process	positive regulation of axon extension
H	0046785	biological_process	microtubule polymerization
H	0048143	biological_process	astrocyte activation
H	0048167	biological_process	regulation of synaptic plasticity
H	0048312	biological_process	intracellular distribution of mitochondria
H	0048699	biological_process	generation of neurons
H	0050808	biological_process	synapse organization
H	0050848	biological_process	regulation of calcium-mediated signaling
H	0051087	molecular_function	protein-folding chaperone binding
H	0051258	biological_process	protein polymerization
H	0051721	molecular_function	protein phosphatase 2A binding
H	0051879	molecular_function	Hsp90 protein binding
H	0060632	biological_process	regulation of microtubule-based movement
H	0061564	biological_process	axon development
H	0070507	biological_process	regulation of microtubule cytoskeleton organization
H	0071813	molecular_function	lipoprotein particle binding
H	0072386	biological_process	plus-end-directed organelle transport along microtubule
H	0090140	biological_process	regulation of mitochondrial fission
H	0090258	biological_process	negative regulation of mitochondrial fission
H	0097386	cellular_component	glial cell projection
H	0097418	cellular_component	neurofibrillary tangle
H	0097435	biological_process	supramolecular fiber organization
H	0098930	biological_process	axonal transport
H	0099077	molecular_function	histone-dependent DNA binding
H	0099609	molecular_function	microtubule lateral binding
H	1900034	biological_process	regulation of cellular response to heat
H	1900452	biological_process	regulation of long-term synaptic depression
H	1902474	biological_process	positive regulation of protein localization to synapse
H	1902936	molecular_function	phosphatidylinositol bisphosphate binding
H	1902988	biological_process	neurofibrillary tangle assembly
H	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
H	1903829	biological_process	positive regulation of protein localization
H	1904115	cellular_component	axon cytoplasm
H	1990000	biological_process	amyloid fibril formation
H	1990090	biological_process	cellular response to nerve growth factor stimulus
H	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
I	0000226	biological_process	microtubule cytoskeleton organization
I	0001774	biological_process	microglial cell activation
I	0003677	molecular_function	DNA binding
I	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
I	0003690	molecular_function	double-stranded DNA binding
I	0003697	molecular_function	single-stranded DNA binding
I	0003723	molecular_function	RNA binding
I	0003779	molecular_function	actin binding
I	0004857	molecular_function	enzyme inhibitor activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0005886	cellular_component	plasma membrane
I	0006974	biological_process	DNA damage response
I	0007267	biological_process	cell-cell signaling
I	0007613	biological_process	memory
I	0008017	molecular_function	microtubule binding
I	0010288	biological_process	response to lead ion
I	0010506	biological_process	regulation of autophagy
I	0010629	biological_process	negative regulation of gene expression
I	0010917	biological_process	negative regulation of mitochondrial membrane potential
I	0015630	cellular_component	microtubule cytoskeleton
I	0016020	cellular_component	membrane
I	0016072	biological_process	rRNA metabolic process
I	0017124	molecular_function	SH3 domain binding
I	0019896	biological_process	axonal transport of mitochondrion
I	0019899	molecular_function	enzyme binding
I	0019901	molecular_function	protein kinase binding
I	0021954	biological_process	central nervous system neuron development
I	0030424	cellular_component	axon
I	0030425	cellular_component	dendrite
I	0030426	cellular_component	growth cone
I	0030673	cellular_component	axolemma
I	0030674	molecular_function	protein-macromolecule adaptor activity
I	0031110	biological_process	regulation of microtubule polymerization or depolymerization
I	0031113	biological_process	regulation of microtubule polymerization
I	0031116	biological_process	positive regulation of microtubule polymerization
I	0031122	biological_process	cytoplasmic microtubule organization
I	0031175	biological_process	neuron projection development
I	0032930	biological_process	positive regulation of superoxide anion generation
I	0033044	biological_process	regulation of chromosome organization
I	0034063	biological_process	stress granule assembly
I	0034185	molecular_function	apolipoprotein binding
I	0034399	cellular_component	nuclear periphery
I	0034452	molecular_function	dynactin binding
I	0034605	biological_process	cellular response to heat
I	0034614	biological_process	cellular response to reactive oxygen species
I	0035091	molecular_function	phosphatidylinositol binding
I	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
I	0036477	cellular_component	somatodendritic compartment
I	0042802	molecular_function	identical protein binding
I	0043005	cellular_component	neuron projection
I	0043025	cellular_component	neuronal cell body
I	0043197	cellular_component	dendritic spine
I	0043565	molecular_function	sequence-specific DNA binding
I	0044297	cellular_component	cell body
I	0044304	cellular_component	main axon
I	0045121	cellular_component	membrane raft
I	0045298	cellular_component	tubulin complex
I	0045773	biological_process	positive regulation of axon extension
I	0046785	biological_process	microtubule polymerization
I	0048143	biological_process	astrocyte activation
I	0048167	biological_process	regulation of synaptic plasticity
I	0048312	biological_process	intracellular distribution of mitochondria
I	0048699	biological_process	generation of neurons
I	0050808	biological_process	synapse organization
I	0050848	biological_process	regulation of calcium-mediated signaling
I	0051087	molecular_function	protein-folding chaperone binding
I	0051258	biological_process	protein polymerization
I	0051721	molecular_function	protein phosphatase 2A binding
I	0051879	molecular_function	Hsp90 protein binding
I	0060632	biological_process	regulation of microtubule-based movement
I	0061564	biological_process	axon development
I	0070507	biological_process	regulation of microtubule cytoskeleton organization
I	0071813	molecular_function	lipoprotein particle binding
I	0072386	biological_process	plus-end-directed organelle transport along microtubule
I	0090140	biological_process	regulation of mitochondrial fission
I	0090258	biological_process	negative regulation of mitochondrial fission
I	0097386	cellular_component	glial cell projection
I	0097418	cellular_component	neurofibrillary tangle
I	0097435	biological_process	supramolecular fiber organization
I	0098930	biological_process	axonal transport
I	0099077	molecular_function	histone-dependent DNA binding
I	0099609	molecular_function	microtubule lateral binding
I	1900034	biological_process	regulation of cellular response to heat
I	1900452	biological_process	regulation of long-term synaptic depression
I	1902474	biological_process	positive regulation of protein localization to synapse
I	1902936	molecular_function	phosphatidylinositol bisphosphate binding
I	1902988	biological_process	neurofibrillary tangle assembly
I	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
I	1903829	biological_process	positive regulation of protein localization
I	1904115	cellular_component	axon cytoplasm
I	1990000	biological_process	amyloid fibril formation
I	1990090	biological_process	cellular response to nerve growth factor stimulus
I	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
J	0000226	biological_process	microtubule cytoskeleton organization
J	0001774	biological_process	microglial cell activation
J	0003677	molecular_function	DNA binding
J	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
J	0003690	molecular_function	double-stranded DNA binding
J	0003697	molecular_function	single-stranded DNA binding
J	0003723	molecular_function	RNA binding
J	0003779	molecular_function	actin binding
J	0004857	molecular_function	enzyme inhibitor activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005886	cellular_component	plasma membrane
J	0006974	biological_process	DNA damage response
J	0007267	biological_process	cell-cell signaling
J	0007613	biological_process	memory
J	0008017	molecular_function	microtubule binding
J	0010288	biological_process	response to lead ion
J	0010506	biological_process	regulation of autophagy
J	0010629	biological_process	negative regulation of gene expression
J	0010917	biological_process	negative regulation of mitochondrial membrane potential
J	0015630	cellular_component	microtubule cytoskeleton
J	0016020	cellular_component	membrane
J	0016072	biological_process	rRNA metabolic process
J	0017124	molecular_function	SH3 domain binding
J	0019896	biological_process	axonal transport of mitochondrion
J	0019899	molecular_function	enzyme binding
J	0019901	molecular_function	protein kinase binding
J	0021954	biological_process	central nervous system neuron development
J	0030424	cellular_component	axon
J	0030425	cellular_component	dendrite
J	0030426	cellular_component	growth cone
J	0030673	cellular_component	axolemma
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0031110	biological_process	regulation of microtubule polymerization or depolymerization
J	0031113	biological_process	regulation of microtubule polymerization
J	0031116	biological_process	positive regulation of microtubule polymerization
J	0031122	biological_process	cytoplasmic microtubule organization
J	0031175	biological_process	neuron projection development
J	0032930	biological_process	positive regulation of superoxide anion generation
J	0033044	biological_process	regulation of chromosome organization
J	0034063	biological_process	stress granule assembly
J	0034185	molecular_function	apolipoprotein binding
J	0034399	cellular_component	nuclear periphery
J	0034452	molecular_function	dynactin binding
J	0034605	biological_process	cellular response to heat
J	0034614	biological_process	cellular response to reactive oxygen species
J	0035091	molecular_function	phosphatidylinositol binding
J	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
J	0036477	cellular_component	somatodendritic compartment
J	0042802	molecular_function	identical protein binding
J	0043005	cellular_component	neuron projection
J	0043025	cellular_component	neuronal cell body
J	0043197	cellular_component	dendritic spine
J	0043565	molecular_function	sequence-specific DNA binding
J	0044297	cellular_component	cell body
J	0044304	cellular_component	main axon
J	0045121	cellular_component	membrane raft
J	0045298	cellular_component	tubulin complex
J	0045773	biological_process	positive regulation of axon extension
J	0046785	biological_process	microtubule polymerization
J	0048143	biological_process	astrocyte activation
J	0048167	biological_process	regulation of synaptic plasticity
J	0048312	biological_process	intracellular distribution of mitochondria
J	0048699	biological_process	generation of neurons
J	0050808	biological_process	synapse organization
J	0050848	biological_process	regulation of calcium-mediated signaling
J	0051087	molecular_function	protein-folding chaperone binding
J	0051258	biological_process	protein polymerization
J	0051721	molecular_function	protein phosphatase 2A binding
J	0051879	molecular_function	Hsp90 protein binding
J	0060632	biological_process	regulation of microtubule-based movement
J	0061564	biological_process	axon development
J	0070507	biological_process	regulation of microtubule cytoskeleton organization
J	0071813	molecular_function	lipoprotein particle binding
J	0072386	biological_process	plus-end-directed organelle transport along microtubule
J	0090140	biological_process	regulation of mitochondrial fission
J	0090258	biological_process	negative regulation of mitochondrial fission
J	0097386	cellular_component	glial cell projection
J	0097418	cellular_component	neurofibrillary tangle
J	0097435	biological_process	supramolecular fiber organization
J	0098930	biological_process	axonal transport
J	0099077	molecular_function	histone-dependent DNA binding
J	0099609	molecular_function	microtubule lateral binding
J	1900034	biological_process	regulation of cellular response to heat
J	1900452	biological_process	regulation of long-term synaptic depression
J	1902474	biological_process	positive regulation of protein localization to synapse
J	1902936	molecular_function	phosphatidylinositol bisphosphate binding
J	1902988	biological_process	neurofibrillary tangle assembly
J	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
J	1903829	biological_process	positive regulation of protein localization
J	1904115	cellular_component	axon cytoplasm
J	1990000	biological_process	amyloid fibril formation
J	1990090	biological_process	cellular response to nerve growth factor stimulus
J	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
K	0000226	biological_process	microtubule cytoskeleton organization
K	0001774	biological_process	microglial cell activation
K	0003677	molecular_function	DNA binding
K	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
K	0003690	molecular_function	double-stranded DNA binding
K	0003697	molecular_function	single-stranded DNA binding
K	0003723	molecular_function	RNA binding
K	0003779	molecular_function	actin binding
K	0004857	molecular_function	enzyme inhibitor activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0005886	cellular_component	plasma membrane
K	0006974	biological_process	DNA damage response
K	0007267	biological_process	cell-cell signaling
K	0007613	biological_process	memory
K	0008017	molecular_function	microtubule binding
K	0010288	biological_process	response to lead ion
K	0010506	biological_process	regulation of autophagy
K	0010629	biological_process	negative regulation of gene expression
K	0010917	biological_process	negative regulation of mitochondrial membrane potential
K	0015630	cellular_component	microtubule cytoskeleton
K	0016020	cellular_component	membrane
K	0016072	biological_process	rRNA metabolic process
K	0017124	molecular_function	SH3 domain binding
K	0019896	biological_process	axonal transport of mitochondrion
K	0019899	molecular_function	enzyme binding
K	0019901	molecular_function	protein kinase binding
K	0021954	biological_process	central nervous system neuron development
K	0030424	cellular_component	axon
K	0030425	cellular_component	dendrite
K	0030426	cellular_component	growth cone
K	0030673	cellular_component	axolemma
K	0030674	molecular_function	protein-macromolecule adaptor activity
K	0031110	biological_process	regulation of microtubule polymerization or depolymerization
K	0031113	biological_process	regulation of microtubule polymerization
K	0031116	biological_process	positive regulation of microtubule polymerization
K	0031122	biological_process	cytoplasmic microtubule organization
K	0031175	biological_process	neuron projection development
K	0032930	biological_process	positive regulation of superoxide anion generation
K	0033044	biological_process	regulation of chromosome organization
K	0034063	biological_process	stress granule assembly
K	0034185	molecular_function	apolipoprotein binding
K	0034399	cellular_component	nuclear periphery
K	0034452	molecular_function	dynactin binding
K	0034605	biological_process	cellular response to heat
K	0034614	biological_process	cellular response to reactive oxygen species
K	0035091	molecular_function	phosphatidylinositol binding
K	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
K	0036477	cellular_component	somatodendritic compartment
K	0042802	molecular_function	identical protein binding
K	0043005	cellular_component	neuron projection
K	0043025	cellular_component	neuronal cell body
K	0043197	cellular_component	dendritic spine
K	0043565	molecular_function	sequence-specific DNA binding
K	0044297	cellular_component	cell body
K	0044304	cellular_component	main axon
K	0045121	cellular_component	membrane raft
K	0045298	cellular_component	tubulin complex
K	0045773	biological_process	positive regulation of axon extension
K	0046785	biological_process	microtubule polymerization
K	0048143	biological_process	astrocyte activation
K	0048167	biological_process	regulation of synaptic plasticity
K	0048312	biological_process	intracellular distribution of mitochondria
K	0048699	biological_process	generation of neurons
K	0050808	biological_process	synapse organization
K	0050848	biological_process	regulation of calcium-mediated signaling
K	0051087	molecular_function	protein-folding chaperone binding
K	0051258	biological_process	protein polymerization
K	0051721	molecular_function	protein phosphatase 2A binding
K	0051879	molecular_function	Hsp90 protein binding
K	0060632	biological_process	regulation of microtubule-based movement
K	0061564	biological_process	axon development
K	0070507	biological_process	regulation of microtubule cytoskeleton organization
K	0071813	molecular_function	lipoprotein particle binding
K	0072386	biological_process	plus-end-directed organelle transport along microtubule
K	0090140	biological_process	regulation of mitochondrial fission
K	0090258	biological_process	negative regulation of mitochondrial fission
K	0097386	cellular_component	glial cell projection
K	0097418	cellular_component	neurofibrillary tangle
K	0097435	biological_process	supramolecular fiber organization
K	0098930	biological_process	axonal transport
K	0099077	molecular_function	histone-dependent DNA binding
K	0099609	molecular_function	microtubule lateral binding
K	1900034	biological_process	regulation of cellular response to heat
K	1900452	biological_process	regulation of long-term synaptic depression
K	1902474	biological_process	positive regulation of protein localization to synapse
K	1902936	molecular_function	phosphatidylinositol bisphosphate binding
K	1902988	biological_process	neurofibrillary tangle assembly
K	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
K	1903829	biological_process	positive regulation of protein localization
K	1904115	cellular_component	axon cytoplasm
K	1990000	biological_process	amyloid fibril formation
K	1990090	biological_process	cellular response to nerve growth factor stimulus
K	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
L	0000226	biological_process	microtubule cytoskeleton organization
L	0001774	biological_process	microglial cell activation
L	0003677	molecular_function	DNA binding
L	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
L	0003690	molecular_function	double-stranded DNA binding
L	0003697	molecular_function	single-stranded DNA binding
L	0003723	molecular_function	RNA binding
L	0003779	molecular_function	actin binding
L	0004857	molecular_function	enzyme inhibitor activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0005886	cellular_component	plasma membrane
L	0006974	biological_process	DNA damage response
L	0007267	biological_process	cell-cell signaling
L	0007613	biological_process	memory
L	0008017	molecular_function	microtubule binding
L	0010288	biological_process	response to lead ion
L	0010506	biological_process	regulation of autophagy
L	0010629	biological_process	negative regulation of gene expression
L	0010917	biological_process	negative regulation of mitochondrial membrane potential
L	0015630	cellular_component	microtubule cytoskeleton
L	0016020	cellular_component	membrane
L	0016072	biological_process	rRNA metabolic process
L	0017124	molecular_function	SH3 domain binding
L	0019896	biological_process	axonal transport of mitochondrion
L	0019899	molecular_function	enzyme binding
L	0019901	molecular_function	protein kinase binding
L	0021954	biological_process	central nervous system neuron development
L	0030424	cellular_component	axon
L	0030425	cellular_component	dendrite
L	0030426	cellular_component	growth cone
L	0030673	cellular_component	axolemma
L	0030674	molecular_function	protein-macromolecule adaptor activity
L	0031110	biological_process	regulation of microtubule polymerization or depolymerization
L	0031113	biological_process	regulation of microtubule polymerization
L	0031116	biological_process	positive regulation of microtubule polymerization
L	0031122	biological_process	cytoplasmic microtubule organization
L	0031175	biological_process	neuron projection development
L	0032930	biological_process	positive regulation of superoxide anion generation
L	0033044	biological_process	regulation of chromosome organization
L	0034063	biological_process	stress granule assembly
L	0034185	molecular_function	apolipoprotein binding
L	0034399	cellular_component	nuclear periphery
L	0034452	molecular_function	dynactin binding
L	0034605	biological_process	cellular response to heat
L	0034614	biological_process	cellular response to reactive oxygen species
L	0035091	molecular_function	phosphatidylinositol binding
L	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
L	0036477	cellular_component	somatodendritic compartment
L	0042802	molecular_function	identical protein binding
L	0043005	cellular_component	neuron projection
L	0043025	cellular_component	neuronal cell body
L	0043197	cellular_component	dendritic spine
L	0043565	molecular_function	sequence-specific DNA binding
L	0044297	cellular_component	cell body
L	0044304	cellular_component	main axon
L	0045121	cellular_component	membrane raft
L	0045298	cellular_component	tubulin complex
L	0045773	biological_process	positive regulation of axon extension
L	0046785	biological_process	microtubule polymerization
L	0048143	biological_process	astrocyte activation
L	0048167	biological_process	regulation of synaptic plasticity
L	0048312	biological_process	intracellular distribution of mitochondria
L	0048699	biological_process	generation of neurons
L	0050808	biological_process	synapse organization
L	0050848	biological_process	regulation of calcium-mediated signaling
L	0051087	molecular_function	protein-folding chaperone binding
L	0051258	biological_process	protein polymerization
L	0051721	molecular_function	protein phosphatase 2A binding
L	0051879	molecular_function	Hsp90 protein binding
L	0060632	biological_process	regulation of microtubule-based movement
L	0061564	biological_process	axon development
L	0070507	biological_process	regulation of microtubule cytoskeleton organization
L	0071813	molecular_function	lipoprotein particle binding
L	0072386	biological_process	plus-end-directed organelle transport along microtubule
L	0090140	biological_process	regulation of mitochondrial fission
L	0090258	biological_process	negative regulation of mitochondrial fission
L	0097386	cellular_component	glial cell projection
L	0097418	cellular_component	neurofibrillary tangle
L	0097435	biological_process	supramolecular fiber organization
L	0098930	biological_process	axonal transport
L	0099077	molecular_function	histone-dependent DNA binding
L	0099609	molecular_function	microtubule lateral binding
L	1900034	biological_process	regulation of cellular response to heat
L	1900452	biological_process	regulation of long-term synaptic depression
L	1902474	biological_process	positive regulation of protein localization to synapse
L	1902936	molecular_function	phosphatidylinositol bisphosphate binding
L	1902988	biological_process	neurofibrillary tangle assembly
L	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
L	1903829	biological_process	positive regulation of protein localization
L	1904115	cellular_component	axon cytoplasm
L	1990000	biological_process	amyloid fibril formation
L	1990090	biological_process	cellular response to nerve growth factor stimulus
L	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus

Functional Information from PROSITE/UniProt

site_id	PS00229
Number of Residues	13
Details	TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG

Chain	Residue	Details
A	GLY261-GLY273
A	GLY292-GLY304
A	GLY323-GLY335
A	GLY355-GLY367

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	Repeat: {"description":"Tau/MAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00824","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	372
Details	Repeat: {"description":"Tau/MAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00824","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	96
Details	Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine; by PHK","evidences":[{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8999860","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	84
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine; by PHK","evidences":[{"source":"PubMed","id":"8999860","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	36
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau","evidences":[{"source":"PubMed","id":"16443603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	72
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---