9PFR
Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) in NTP-bound elongation state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001172 | biological_process | RNA-templated transcription |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| A | 0039689 | biological_process | negative stranded viral RNA replication |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0062105 | molecular_function | RNA 2'-O-methyltransferase activity |
| A | 0106005 | biological_process | RNA 5'-cap (guanine-N7)-methylation |
| B | 0001172 | biological_process | RNA-templated transcription |
| B | 0030430 | cellular_component | host cell cytoplasm |
| C | 0001172 | biological_process | RNA-templated transcription |
| C | 0030430 | cellular_component | host cell cytoplasm |
| D | 0001172 | biological_process | RNA-templated transcription |
| D | 0030430 | cellular_component | host cell cytoplasm |
| E | 0001172 | biological_process | RNA-templated transcription |
| E | 0030430 | cellular_component | host cell cytoplasm |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 184 |
| Details | Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 188 |
| Details | Domain: {"description":"Mononegavirus-type SAM-dependent 2'-O-MTase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00923","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; for GDP polyribonucleotidyltransferase activity","evidences":[{"source":"UniProtKB","id":"P03523","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For mRNA (guanine-N(7)-)-methyltransferase and mRNA (nucleoside-2'-O-)-methyltransferase","evidences":[{"source":"UniProtKB","id":"Q6WB93","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31495574","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31953395","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q6WB93","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
