9PD4

NER dual incision complex - DuIM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000112	cellular_component	nucleotide-excision repair factor 3 complex
A	0000439	cellular_component	transcription factor TFIIH core complex
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005669	cellular_component	transcription factor TFIID complex
A	0005675	cellular_component	transcription factor TFIIH holo complex
A	0006265	biological_process	DNA topological change
A	0006281	biological_process	DNA repair
A	0006283	biological_process	transcription-coupled nucleotide-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0006915	biological_process	apoptotic process
A	0006979	biological_process	response to oxidative stress
A	0008104	biological_process	intracellular protein localization
A	0009411	biological_process	response to UV
A	0016887	molecular_function	ATP hydrolysis activity
A	0035315	biological_process	hair cell differentiation
A	0043065	biological_process	positive regulation of apoptotic process
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0048568	biological_process	embryonic organ development
A	0097550	cellular_component	transcription preinitiation complex
A	1901990	biological_process	regulation of mitotic cell cycle phase transition
A	1990841	molecular_function	promoter-specific chromatin binding
B	0000439	cellular_component	transcription factor TFIIH core complex
B	0001666	biological_process	response to hypoxia
B	0003678	molecular_function	DNA helicase activity
B	0003684	molecular_function	damaged DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005669	cellular_component	transcription factor TFIID complex
B	0005675	cellular_component	transcription factor TFIIH holo complex
B	0005737	cellular_component	cytoplasm
B	0005819	cellular_component	spindle
B	0006283	biological_process	transcription-coupled nucleotide-excision repair
B	0006289	biological_process	nucleotide-excision repair
B	0006351	biological_process	DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006366	biological_process	transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006915	biological_process	apoptotic process
B	0006979	biological_process	response to oxidative stress
B	0007059	biological_process	chromosome segregation
B	0016887	molecular_function	ATP hydrolysis activity
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0035315	biological_process	hair cell differentiation
B	0043139	molecular_function	5'-3' DNA helicase activity
B	0045951	biological_process	positive regulation of mitotic recombination
B	0048568	biological_process	embryonic organ development
B	0070516	cellular_component	CAK-ERCC2 complex
B	0071817	cellular_component	MMXD complex
B	1901990	biological_process	regulation of mitotic cell cycle phase transition
C	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
C	0000439	cellular_component	transcription factor TFIIH core complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005675	cellular_component	transcription factor TFIIH holo complex
C	0006281	biological_process	DNA repair
C	0006289	biological_process	nucleotide-excision repair
C	0006360	biological_process	transcription by RNA polymerase I
C	0006366	biological_process	transcription by RNA polymerase II
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0009755	biological_process	hormone-mediated signaling pathway
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0046966	molecular_function	nuclear thyroid hormone receptor binding
D	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
D	0000439	cellular_component	transcription factor TFIIH core complex
D	0003690	molecular_function	double-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005669	cellular_component	transcription factor TFIID complex
D	0005675	cellular_component	transcription factor TFIIH holo complex
D	0006281	biological_process	DNA repair
D	0006289	biological_process	nucleotide-excision repair
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
D	0016607	cellular_component	nuclear speck
E	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
E	0000439	cellular_component	transcription factor TFIIH core complex
E	0002031	biological_process	G protein-coupled receptor internalization
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005669	cellular_component	transcription factor TFIID complex
E	0005675	cellular_component	transcription factor TFIIH holo complex
E	0006289	biological_process	nucleotide-excision repair
E	0006366	biological_process	transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0009411	biological_process	response to UV
E	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
E	0016607	cellular_component	nuclear speck
F	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
F	0000439	cellular_component	transcription factor TFIIH core complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005669	cellular_component	transcription factor TFIID complex
F	0005675	cellular_component	transcription factor TFIIH holo complex
F	0006281	biological_process	DNA repair
F	0006289	biological_process	nucleotide-excision repair
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
F	0097550	cellular_component	transcription preinitiation complex
G	0000439	cellular_component	transcription factor TFIIH core complex
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005669	cellular_component	transcription factor TFIID complex
G	0005675	cellular_component	transcription factor TFIIH holo complex
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006289	biological_process	nucleotide-excision repair
G	0006294	biological_process	nucleotide-excision repair, preincision complex assembly
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
K	0000110	cellular_component	nucleotide-excision repair factor 1 complex
K	0000715	biological_process	nucleotide-excision repair, DNA damage recognition
K	0003684	molecular_function	damaged DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005662	cellular_component	DNA replication factor A complex
K	0006281	biological_process	DNA repair
K	0006284	biological_process	base-excision repair
K	0006289	biological_process	nucleotide-excision repair
K	0009650	biological_process	UV protection
K	0016604	cellular_component	nuclear body
K	0019904	molecular_function	protein domain specific binding
K	0034504	biological_process	protein localization to nucleus
K	0042803	molecular_function	protein homodimerization activity
K	0070914	biological_process	UV-damage excision repair
K	1901255	biological_process	nucleotide-excision repair involved in interstrand cross-link repair
K	1990837	molecular_function	sequence-specific double-stranded DNA binding
N	0000228	cellular_component	nuclear chromosome
N	0000723	biological_process	telomere maintenance
N	0000724	biological_process	double-strand break repair via homologous recombination
N	0000781	cellular_component	chromosome, telomeric region
N	0000793	cellular_component	condensed chromosome
N	0000794	cellular_component	condensed nuclear chromosome
N	0000800	cellular_component	lateral element
N	0001673	cellular_component	male germ cell nucleus
N	0003682	molecular_function	chromatin binding
N	0003684	molecular_function	damaged DNA binding
N	0003697	molecular_function	single-stranded DNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005662	cellular_component	DNA replication factor A complex
N	0006260	biological_process	DNA replication
N	0006261	biological_process	DNA-templated DNA replication
N	0006281	biological_process	DNA repair
N	0006284	biological_process	base-excision repair
N	0006289	biological_process	nucleotide-excision repair
N	0006298	biological_process	mismatch repair
N	0006310	biological_process	DNA recombination
N	0006325	biological_process	chromatin organization
N	0006974	biological_process	DNA damage response
N	0007004	biological_process	telomere maintenance via telomerase
N	0016605	cellular_component	PML body
N	0034502	biological_process	protein localization to chromosome
N	0035861	cellular_component	site of double-strand break
N	0043047	molecular_function	single-stranded telomeric DNA binding
N	0090734	cellular_component	site of DNA damage
N	0098505	molecular_function	G-rich strand telomeric DNA binding
N	0140463	molecular_function	chromatin-protein adaptor activity
N	1990166	biological_process	protein localization to site of double-strand break
O	0000077	biological_process	DNA damage checkpoint signaling
O	0000723	biological_process	telomere maintenance
O	0000724	biological_process	double-strand break repair via homologous recombination
O	0000781	cellular_component	chromosome, telomeric region
O	0000785	cellular_component	chromatin
O	0003677	molecular_function	DNA binding
O	0003684	molecular_function	damaged DNA binding
O	0003697	molecular_function	single-stranded DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005662	cellular_component	DNA replication factor A complex
O	0006260	biological_process	DNA replication
O	0006284	biological_process	base-excision repair
O	0006289	biological_process	nucleotide-excision repair
O	0006298	biological_process	mismatch repair
O	0010569	biological_process	regulation of double-strand break repair via homologous recombination
O	0016604	cellular_component	nuclear body
O	0016605	cellular_component	PML body
O	0019899	molecular_function	enzyme binding
O	0019903	molecular_function	protein phosphatase binding
O	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
O	0031625	molecular_function	ubiquitin protein ligase binding
O	0034502	biological_process	protein localization to chromosome
O	0035861	cellular_component	site of double-strand break
O	0042162	molecular_function	telomeric repeat DNA binding
O	0098505	molecular_function	G-rich strand telomeric DNA binding
O	2000001	biological_process	regulation of DNA damage checkpoint
P	0000723	biological_process	telomere maintenance
P	0000724	biological_process	double-strand break repair via homologous recombination
P	0003684	molecular_function	damaged DNA binding
P	0003697	molecular_function	single-stranded DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005662	cellular_component	DNA replication factor A complex
P	0006260	biological_process	DNA replication
P	0006281	biological_process	DNA repair
P	0006284	biological_process	base-excision repair
P	0006289	biological_process	nucleotide-excision repair
P	0006298	biological_process	mismatch repair
P	0035861	cellular_component	site of double-strand break
Q	0000109	cellular_component	nucleotide-excision repair complex
Q	0000110	cellular_component	nucleotide-excision repair factor 1 complex
Q	0000712	biological_process	resolution of meiotic recombination intermediates
Q	0000723	biological_process	telomere maintenance
Q	0000724	biological_process	double-strand break repair via homologous recombination
Q	0000781	cellular_component	chromosome, telomeric region
Q	0001094	molecular_function	TFIID-class transcription factor complex binding
Q	0003677	molecular_function	DNA binding
Q	0003684	molecular_function	damaged DNA binding
Q	0003697	molecular_function	single-stranded DNA binding
Q	0004520	molecular_function	DNA endonuclease activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005694	cellular_component	chromosome
Q	0006281	biological_process	DNA repair
Q	0006289	biological_process	nucleotide-excision repair
Q	0006303	biological_process	double-strand break repair via nonhomologous end joining
Q	0006312	biological_process	mitotic recombination
Q	0009411	biological_process	response to UV
Q	0010521	molecular_function	telomerase inhibitor activity
Q	0016604	cellular_component	nuclear body
Q	0032205	biological_process	negative regulation of telomere maintenance
Q	0034644	biological_process	cellular response to UV
Q	0042802	molecular_function	identical protein binding
Q	0061819	biological_process	telomeric DNA-containing double minutes formation
Q	0070522	cellular_component	ERCC4-ERCC1 complex
Q	1901255	biological_process	nucleotide-excision repair involved in interstrand cross-link repair
Q	1904357	biological_process	negative regulation of telomere maintenance via telomere lengthening
Q	1905765	biological_process	negative regulation of protection from non-homologous end joining at telomere
Q	1990599	molecular_function	3' overhang single-stranded DNA endonuclease activity
Q	1990841	molecular_function	promoter-specific chromatin binding
R	0000014	molecular_function	single-stranded DNA endonuclease activity
R	0000109	cellular_component	nucleotide-excision repair complex
R	0000110	cellular_component	nucleotide-excision repair factor 1 complex
R	0000723	biological_process	telomere maintenance
R	0000781	cellular_component	chromosome, telomeric region
R	0001094	molecular_function	TFIID-class transcription factor complex binding
R	0003677	molecular_function	DNA binding
R	0003684	molecular_function	damaged DNA binding
R	0003697	molecular_function	single-stranded DNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0006281	biological_process	DNA repair
R	0006289	biological_process	nucleotide-excision repair
R	0006302	biological_process	double-strand break repair
R	0006303	biological_process	double-strand break repair via nonhomologous end joining
R	0006310	biological_process	DNA recombination
R	0006312	biological_process	mitotic recombination
R	0006979	biological_process	response to oxidative stress
R	0032204	biological_process	regulation of telomere maintenance
R	0032205	biological_process	negative regulation of telomere maintenance
R	0061819	biological_process	telomeric DNA-containing double minutes formation
R	0070522	cellular_component	ERCC4-ERCC1 complex
R	0070914	biological_process	UV-damage excision repair
R	0090656	biological_process	t-circle formation
R	1904431	biological_process	positive regulation of t-circle formation
R	1905765	biological_process	negative regulation of protection from non-homologous end joining at telomere
R	1990599	molecular_function	3' overhang single-stranded DNA endonuclease activity
R	1990841	molecular_function	promoter-specific chromatin binding
S	0000109	cellular_component	nucleotide-excision repair complex
S	0000405	molecular_function	bubble DNA binding
S	0000724	biological_process	double-strand break repair via homologous recombination
S	0000993	molecular_function	RNA polymerase II complex binding
S	0003684	molecular_function	damaged DNA binding
S	0003690	molecular_function	double-stranded DNA binding
S	0003697	molecular_function	single-stranded DNA binding
S	0004519	molecular_function	endonuclease activity
S	0004520	molecular_function	DNA endonuclease activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005662	cellular_component	DNA replication factor A complex
S	0005694	cellular_component	chromosome
S	0006283	biological_process	transcription-coupled nucleotide-excision repair
S	0006285	biological_process	base-excision repair, AP site formation
S	0006289	biological_process	nucleotide-excision repair
S	0006310	biological_process	DNA recombination
S	0008047	molecular_function	enzyme activator activity
S	0009411	biological_process	response to UV
S	0010225	biological_process	response to UV-C
S	0032991	cellular_component	protein-containing complex
S	0042803	molecular_function	protein homodimerization activity
S	0043066	biological_process	negative regulation of apoptotic process
S	0044877	molecular_function	protein-containing complex binding

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H

Chain	Residue	Details
E	CYS360-HIS380

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN

Chain	Residue	Details
B	ALA229-ASN238

---

site_id	PS00752
Number of Residues	25
Details	XPA_1 XPA protein signature 1. CeECgkeFm.DsyLmnhFdlptCdnC

Chain	Residue	Details
K	CYS105-CYS129

---

site_id	PS00753
Number of Residues	17
Details	XPA_2 XPA protein signature 2. LITKTEaKqEYLLkDcD

Chain	Residue	Details
K	LEU138-ASP154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	437
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	160
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	199
Details	Region: {"description":"Mediates interaction with MMS19"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	13
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	176
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	34
Details	Zinc finger: {"description":"C4-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"A0JN27","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	24
Details	Zinc finger: {"evidences":[{"source":"PubMed","id":"2234061","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D4U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16540648","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	158
Details	DNA binding: {"description":"OB"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	22
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	13
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"26474068","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"20705237","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"26474068","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	Modified residue: {"description":"N-acetylvaline","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	80
Details	Domain: {"description":"ERCC4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	21
Details	Region: {"description":"Leucine-zipper 1","evidences":[{"source":"PubMed","id":"8887684","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9QZD4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	22
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	35
Details	Domain: {"description":"UBM","evidences":[{"source":"PROSITE-ProRule","id":"PRU01409","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	95
Details	Region: {"description":"I-domain","evidences":[{"source":"PubMed","id":"32522879","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	16
Details	Region: {"description":"DNA-binding; may bind to the undamaged single-strand DNA of the DNA repair bubble","evidences":[{"source":"PubMed","id":"32821917","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TUW","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6TUX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	32
Details	Region: {"description":"DNA-binding; H2TH (helix-2turn-helix) motif which binds double-stranded DNA","evidences":[{"source":"PubMed","id":"32821917","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TUW","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6TUX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	6
Details	Region: {"description":"DNA-binding; may bind double-stranded DNA","evidences":[{"source":"PubMed","id":"32821917","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TUW","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6TUX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P39748","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---