9OX7

In situ microtubule structure in the axon of a human neuron

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0000793	cellular_component	condensed chromosome
A	0001764	biological_process	neuron migration
A	0001964	biological_process	startle response
A	0003924	molecular_function	GTPase activity
A	0005198	molecular_function	structural molecule activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005879	cellular_component	axonemal microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006457	biological_process	protein folding
A	0006458	biological_process	'de novo' protein folding
A	0006886	biological_process	intracellular protein transport
A	0007017	biological_process	microtubule-based process
A	0007098	biological_process	centrosome cycle
A	0007224	biological_process	smoothened signaling pathway
A	0007613	biological_process	memory
A	0007626	biological_process	locomotory behavior
A	0008017	molecular_function	microtubule binding
A	0008344	biological_process	adult locomotory behavior
A	0008542	biological_process	visual learning
A	0009612	biological_process	response to mechanical stimulus
A	0010001	biological_process	glial cell differentiation
A	0010467	biological_process	gene expression
A	0015630	cellular_component	microtubule cytoskeleton
A	0021542	biological_process	dentate gyrus development
A	0021696	biological_process	cerebellar cortex morphogenesis
A	0021766	biological_process	hippocampus development
A	0021859	biological_process	pyramidal neuron differentiation
A	0021987	biological_process	cerebral cortex development
A	0022008	biological_process	neurogenesis
A	0030182	biological_process	neuron differentiation
A	0030317	biological_process	flagellated sperm motility
A	0030534	biological_process	adult behavior
A	0030705	biological_process	cytoskeleton-dependent intracellular transport
A	0031594	cellular_component	neuromuscular junction
A	0034612	biological_process	response to tumor necrosis factor
A	0035371	cellular_component	microtubule plus-end
A	0035641	biological_process	locomotory exploration behavior
A	0036126	cellular_component	sperm flagellum
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0045202	cellular_component	synapse
A	0046785	biological_process	microtubule polymerization
A	0046982	molecular_function	protein heterodimerization activity
A	0048853	biological_process	forebrain morphogenesis
A	0048873	biological_process	homeostasis of number of cells within a tissue
A	0050807	biological_process	regulation of synapse organization
A	0050808	biological_process	synapse organization
A	0050821	biological_process	protein stabilization
A	0051087	molecular_function	protein-folding chaperone binding
A	0051301	biological_process	cell division
A	0051402	biological_process	neuron apoptotic process
A	0055037	cellular_component	recycling endosome
A	0061744	biological_process	motor behavior
A	0070062	cellular_component	extracellular exosome
A	0071277	biological_process	cellular response to calcium ion
A	0072384	biological_process	organelle transport along microtubule
A	0140058	biological_process	neuron projection arborization
A	1902065	biological_process	response to L-glutamate
B	0000278	biological_process	mitotic cell cycle
B	0001764	biological_process	neuron migration
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005929	cellular_component	cilium
B	0007010	biological_process	cytoskeleton organization
B	0007017	biological_process	microtubule-based process
B	0015630	cellular_component	microtubule cytoskeleton
B	0045171	cellular_component	intercellular bridge
B	0046982	molecular_function	protein heterodimerization activity
B	0072686	cellular_component	mitotic spindle
B	0097228	cellular_component	sperm principal piece
B	0097229	cellular_component	sperm end piece
B	0097542	cellular_component	ciliary tip
B	1902669	biological_process	positive regulation of axon guidance
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0000793	cellular_component	condensed chromosome
C	0001764	biological_process	neuron migration
C	0001964	biological_process	startle response
C	0003924	molecular_function	GTPase activity
C	0005198	molecular_function	structural molecule activity
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005879	cellular_component	axonemal microtubule
C	0005881	cellular_component	cytoplasmic microtubule
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006457	biological_process	protein folding
C	0006458	biological_process	'de novo' protein folding
C	0006886	biological_process	intracellular protein transport
C	0007017	biological_process	microtubule-based process
C	0007098	biological_process	centrosome cycle
C	0007224	biological_process	smoothened signaling pathway
C	0007613	biological_process	memory
C	0007626	biological_process	locomotory behavior
C	0008017	molecular_function	microtubule binding
C	0008344	biological_process	adult locomotory behavior
C	0008542	biological_process	visual learning
C	0009612	biological_process	response to mechanical stimulus
C	0010001	biological_process	glial cell differentiation
C	0010467	biological_process	gene expression
C	0015630	cellular_component	microtubule cytoskeleton
C	0021542	biological_process	dentate gyrus development
C	0021696	biological_process	cerebellar cortex morphogenesis
C	0021766	biological_process	hippocampus development
C	0021859	biological_process	pyramidal neuron differentiation
C	0021987	biological_process	cerebral cortex development
C	0022008	biological_process	neurogenesis
C	0030182	biological_process	neuron differentiation
C	0030317	biological_process	flagellated sperm motility
C	0030534	biological_process	adult behavior
C	0030705	biological_process	cytoskeleton-dependent intracellular transport
C	0031594	cellular_component	neuromuscular junction
C	0034612	biological_process	response to tumor necrosis factor
C	0035371	cellular_component	microtubule plus-end
C	0035641	biological_process	locomotory exploration behavior
C	0036126	cellular_component	sperm flagellum
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0042802	molecular_function	identical protein binding
C	0044877	molecular_function	protein-containing complex binding
C	0045202	cellular_component	synapse
C	0046785	biological_process	microtubule polymerization
C	0046982	molecular_function	protein heterodimerization activity
C	0048853	biological_process	forebrain morphogenesis
C	0048873	biological_process	homeostasis of number of cells within a tissue
C	0050807	biological_process	regulation of synapse organization
C	0050808	biological_process	synapse organization
C	0050821	biological_process	protein stabilization
C	0051087	molecular_function	protein-folding chaperone binding
C	0051301	biological_process	cell division
C	0051402	biological_process	neuron apoptotic process
C	0055037	cellular_component	recycling endosome
C	0061744	biological_process	motor behavior
C	0070062	cellular_component	extracellular exosome
C	0071277	biological_process	cellular response to calcium ion
C	0072384	biological_process	organelle transport along microtubule
C	0140058	biological_process	neuron projection arborization
C	1902065	biological_process	response to L-glutamate
D	0000278	biological_process	mitotic cell cycle
D	0001764	biological_process	neuron migration
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0005929	cellular_component	cilium
D	0007010	biological_process	cytoskeleton organization
D	0007017	biological_process	microtubule-based process
D	0015630	cellular_component	microtubule cytoskeleton
D	0045171	cellular_component	intercellular bridge
D	0046982	molecular_function	protein heterodimerization activity
D	0072686	cellular_component	mitotic spindle
D	0097228	cellular_component	sperm principal piece
D	0097229	cellular_component	sperm end piece
D	0097542	cellular_component	ciliary tip
D	1902669	biological_process	positive regulation of axon guidance
E	0000278	biological_process	mitotic cell cycle
E	0001764	biological_process	neuron migration
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005929	cellular_component	cilium
E	0007010	biological_process	cytoskeleton organization
E	0007017	biological_process	microtubule-based process
E	0015630	cellular_component	microtubule cytoskeleton
E	0045171	cellular_component	intercellular bridge
E	0046982	molecular_function	protein heterodimerization activity
E	0072686	cellular_component	mitotic spindle
E	0097228	cellular_component	sperm principal piece
E	0097229	cellular_component	sperm end piece
E	0097542	cellular_component	ciliary tip
E	1902669	biological_process	positive regulation of axon guidance
F	0000278	biological_process	mitotic cell cycle
F	0001764	biological_process	neuron migration
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0005929	cellular_component	cilium
F	0007010	biological_process	cytoskeleton organization
F	0007017	biological_process	microtubule-based process
F	0015630	cellular_component	microtubule cytoskeleton
F	0045171	cellular_component	intercellular bridge
F	0046982	molecular_function	protein heterodimerization activity
F	0072686	cellular_component	mitotic spindle
F	0097228	cellular_component	sperm principal piece
F	0097229	cellular_component	sperm end piece
F	0097542	cellular_component	ciliary tip
F	1902669	biological_process	positive regulation of axon guidance
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0000793	cellular_component	condensed chromosome
G	0001764	biological_process	neuron migration
G	0001964	biological_process	startle response
G	0003924	molecular_function	GTPase activity
G	0005198	molecular_function	structural molecule activity
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005879	cellular_component	axonemal microtubule
G	0005881	cellular_component	cytoplasmic microtubule
G	0005886	cellular_component	plasma membrane
G	0005929	cellular_component	cilium
G	0006457	biological_process	protein folding
G	0006458	biological_process	'de novo' protein folding
G	0006886	biological_process	intracellular protein transport
G	0007017	biological_process	microtubule-based process
G	0007098	biological_process	centrosome cycle
G	0007224	biological_process	smoothened signaling pathway
G	0007613	biological_process	memory
G	0007626	biological_process	locomotory behavior
G	0008017	molecular_function	microtubule binding
G	0008344	biological_process	adult locomotory behavior
G	0008542	biological_process	visual learning
G	0009612	biological_process	response to mechanical stimulus
G	0010001	biological_process	glial cell differentiation
G	0010467	biological_process	gene expression
G	0015630	cellular_component	microtubule cytoskeleton
G	0021542	biological_process	dentate gyrus development
G	0021696	biological_process	cerebellar cortex morphogenesis
G	0021766	biological_process	hippocampus development
G	0021859	biological_process	pyramidal neuron differentiation
G	0021987	biological_process	cerebral cortex development
G	0022008	biological_process	neurogenesis
G	0030182	biological_process	neuron differentiation
G	0030317	biological_process	flagellated sperm motility
G	0030534	biological_process	adult behavior
G	0030705	biological_process	cytoskeleton-dependent intracellular transport
G	0031594	cellular_component	neuromuscular junction
G	0034612	biological_process	response to tumor necrosis factor
G	0035371	cellular_component	microtubule plus-end
G	0035641	biological_process	locomotory exploration behavior
G	0036126	cellular_component	sperm flagellum
G	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
G	0042802	molecular_function	identical protein binding
G	0044877	molecular_function	protein-containing complex binding
G	0045202	cellular_component	synapse
G	0046785	biological_process	microtubule polymerization
G	0046982	molecular_function	protein heterodimerization activity
G	0048853	biological_process	forebrain morphogenesis
G	0048873	biological_process	homeostasis of number of cells within a tissue
G	0050807	biological_process	regulation of synapse organization
G	0050808	biological_process	synapse organization
G	0050821	biological_process	protein stabilization
G	0051087	molecular_function	protein-folding chaperone binding
G	0051301	biological_process	cell division
G	0051402	biological_process	neuron apoptotic process
G	0055037	cellular_component	recycling endosome
G	0061744	biological_process	motor behavior
G	0070062	cellular_component	extracellular exosome
G	0071277	biological_process	cellular response to calcium ion
G	0072384	biological_process	organelle transport along microtubule
G	0140058	biological_process	neuron projection arborization
G	1902065	biological_process	response to L-glutamate
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0000793	cellular_component	condensed chromosome
H	0001764	biological_process	neuron migration
H	0001964	biological_process	startle response
H	0003924	molecular_function	GTPase activity
H	0005198	molecular_function	structural molecule activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005879	cellular_component	axonemal microtubule
H	0005881	cellular_component	cytoplasmic microtubule
H	0005886	cellular_component	plasma membrane
H	0005929	cellular_component	cilium
H	0006457	biological_process	protein folding
H	0006458	biological_process	'de novo' protein folding
H	0006886	biological_process	intracellular protein transport
H	0007017	biological_process	microtubule-based process
H	0007098	biological_process	centrosome cycle
H	0007224	biological_process	smoothened signaling pathway
H	0007613	biological_process	memory
H	0007626	biological_process	locomotory behavior
H	0008017	molecular_function	microtubule binding
H	0008344	biological_process	adult locomotory behavior
H	0008542	biological_process	visual learning
H	0009612	biological_process	response to mechanical stimulus
H	0010001	biological_process	glial cell differentiation
H	0010467	biological_process	gene expression
H	0015630	cellular_component	microtubule cytoskeleton
H	0021542	biological_process	dentate gyrus development
H	0021696	biological_process	cerebellar cortex morphogenesis
H	0021766	biological_process	hippocampus development
H	0021859	biological_process	pyramidal neuron differentiation
H	0021987	biological_process	cerebral cortex development
H	0022008	biological_process	neurogenesis
H	0030182	biological_process	neuron differentiation
H	0030317	biological_process	flagellated sperm motility
H	0030534	biological_process	adult behavior
H	0030705	biological_process	cytoskeleton-dependent intracellular transport
H	0031594	cellular_component	neuromuscular junction
H	0034612	biological_process	response to tumor necrosis factor
H	0035371	cellular_component	microtubule plus-end
H	0035641	biological_process	locomotory exploration behavior
H	0036126	cellular_component	sperm flagellum
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0042802	molecular_function	identical protein binding
H	0044877	molecular_function	protein-containing complex binding
H	0045202	cellular_component	synapse
H	0046785	biological_process	microtubule polymerization
H	0046982	molecular_function	protein heterodimerization activity
H	0048853	biological_process	forebrain morphogenesis
H	0048873	biological_process	homeostasis of number of cells within a tissue
H	0050807	biological_process	regulation of synapse organization
H	0050808	biological_process	synapse organization
H	0050821	biological_process	protein stabilization
H	0051087	molecular_function	protein-folding chaperone binding
H	0051301	biological_process	cell division
H	0051402	biological_process	neuron apoptotic process
H	0055037	cellular_component	recycling endosome
H	0061744	biological_process	motor behavior
H	0070062	cellular_component	extracellular exosome
H	0071277	biological_process	cellular response to calcium ion
H	0072384	biological_process	organelle transport along microtubule
H	0140058	biological_process	neuron projection arborization
H	1902065	biological_process	response to L-glutamate

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
B	GLY140-GLY146

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q3KRE8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"PubMed","id":"16371510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---