9OVV
Heteromeric GluA1/A2-CNIH1 in the activated state, composite map of LBD-TMD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| E | 0000139 | cellular_component | Golgi membrane |
| E | 0005515 | molecular_function | protein binding |
| E | 0005789 | cellular_component | endoplasmic reticulum membrane |
| E | 0006955 | biological_process | immune response |
| E | 0007165 | biological_process | signal transduction |
| E | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| E | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| E | 0038024 | molecular_function | cargo receptor activity |
| F | 0000139 | cellular_component | Golgi membrane |
| F | 0005515 | molecular_function | protein binding |
| F | 0005789 | cellular_component | endoplasmic reticulum membrane |
| F | 0006955 | biological_process | immune response |
| F | 0007165 | biological_process | signal transduction |
| F | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| F | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| F | 0038024 | molecular_function | cargo receptor activity |
| G | 0000139 | cellular_component | Golgi membrane |
| G | 0005515 | molecular_function | protein binding |
| G | 0005789 | cellular_component | endoplasmic reticulum membrane |
| G | 0006955 | biological_process | immune response |
| G | 0007165 | biological_process | signal transduction |
| G | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| G | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| G | 0038024 | molecular_function | cargo receptor activity |
| H | 0000139 | cellular_component | Golgi membrane |
| H | 0005515 | molecular_function | protein binding |
| H | 0005789 | cellular_component | endoplasmic reticulum membrane |
| H | 0006955 | biological_process | immune response |
| H | 0007165 | biological_process | signal transduction |
| H | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| H | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| H | 0038024 | molecular_function | cargo receptor activity |
Functional Information from PROSITE/UniProt
| site_id | PS01340 |
| Number of Residues | 15 |
| Details | CORNICHON Cornichon family signature. IafdELktDYkNPID |
| Chain | Residue | Details |
| E | ILE29-ASP43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | Intramembrane: {"description":"Helical; Pore-forming","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Intramembrane: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=M4","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P42262","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"7877986","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 30 |
| Details | Intramembrane: {"description":"Helical; Pore-forming"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Intramembrane: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 10 |
| Details | Topological domain: {"description":"Cytoplasmic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=M4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 240 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 96 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 176 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
