Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9OPY

Structure of the sweet receptor in the apo state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001582	biological_process	detection of chemical stimulus involved in sensory perception of sweet taste
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008527	molecular_function	taste receptor activity
A	0016020	cellular_component	membrane
A	0032467	biological_process	positive regulation of cytokinesis
A	0033041	molecular_function	sweet taste receptor activity
A	0038037	cellular_component	G protein-coupled receptor dimeric complex
A	0043235	cellular_component	signaling receptor complex
A	0050909	biological_process	sensory perception of taste
A	0050916	biological_process	sensory perception of sweet taste
A	1903767	cellular_component	sweet taste receptor complex
B	0001582	biological_process	detection of chemical stimulus involved in sensory perception of sweet taste
B	0004930	molecular_function	G protein-coupled receptor activity
B	0005515	molecular_function	protein binding
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0008527	molecular_function	taste receptor activity
B	0016020	cellular_component	membrane
B	0033041	molecular_function	sweet taste receptor activity
B	0038037	cellular_component	G protein-coupled receptor dimeric complex
B	0050916	biological_process	sensory perception of sweet taste
B	0050917	biological_process	sensory perception of umami taste
B	1903767	cellular_component	sweet taste receptor complex

Functional Information from PROSITE/UniProt

site_id	PS00980
Number of Residues	25
Details	G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCYdCvdCkagsYrkhp.DdfTCtpC

Chain	Residue	Details
B	CYS522-CYS546
A	CYS513-CYS538

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"40339580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40555359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9UT8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"9NOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OPY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	49
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"40339580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40555359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9UT8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"9NOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OPY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"40339580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40555359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9UT8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"9NOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OPY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	37
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"40339580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40555359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9UT8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"9NOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OPY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"40339580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40555359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9UT8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"9NOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OPY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"40339580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40555359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9UT8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"9NOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OPY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"40339580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40555359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9UT8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"9NOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OPY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"40339580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40555359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9UT8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"9NOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OPY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"40339580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40555359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9UT8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"9NOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OPY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	7
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"40339580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9NOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9NOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9NOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9NOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9NOV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9NOW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"40339580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9NOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9NOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9NOT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	43
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	44
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"40754567","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OQ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	9
Details	Region: {"description":"Required for brazzein responsiveness","evidences":[{"source":"UniProtKB","id":"Q7RTX0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; when associated with variant T-60","evidences":[{"source":"PubMed","id":"11326277","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	9
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)