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9OM6

22bin20S complex (NSF-alphaSNAP-2:2 syntaxin-1a:SNAP-25), 4:2:2 alphaSNAP-syntaxin-1a-SNAP-25 subcomplex local refinement, hydrolyzing, class 23

Functional Information from GO Data
ChainGOidnamespacecontents
A0000149molecular_functionSNARE binding
A0001669cellular_componentacrosomal vesicle
A0001956biological_processpositive regulation of neurotransmitter secretion
A0005484molecular_functionSNAP receptor activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006836biological_processneurotransmitter transport
A0006886biological_processintracellular protein transport
A0006887biological_processexocytosis
A0006906biological_processvesicle fusion
A0008021cellular_componentsynaptic vesicle
A0008076cellular_componentvoltage-gated potassium channel complex
A0009629biological_processresponse to gravity
A0010701biological_processpositive regulation of norepinephrine secretion
A0010807biological_processregulation of synaptic vesicle priming
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016081biological_processsynaptic vesicle docking
A0016192biological_processvesicle-mediated transport
A0016925biological_processprotein sumoylation
A0017022molecular_functionmyosin binding
A0017156biological_processcalcium-ion regulated exocytosis
A0017157biological_processregulation of exocytosis
A0019855molecular_functioncalcium channel inhibitor activity
A0019869molecular_functionchloride channel inhibitor activity
A0019900molecular_functionkinase binding
A0030073biological_processinsulin secretion
A0030141cellular_componentsecretory granule
A0030424cellular_componentaxon
A0030672cellular_componentsynaptic vesicle membrane
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031201cellular_componentSNARE complex
A0031410cellular_componentcytoplasmic vesicle
A0031965cellular_componentnuclear membrane
A0032028molecular_functionmyosin head/neck binding
A0032940biological_processsecretion by cell
A0032991cellular_componentprotein-containing complex
A0033605biological_processpositive regulation of catecholamine secretion
A0035493biological_processSNARE complex assembly
A0035494biological_processSNARE complex disassembly
A0042641cellular_componentactomyosin
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0043005cellular_componentneuron projection
A0043008molecular_functionATP-dependent protein binding
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0045055biological_processregulated exocytosis
A0045202cellular_componentsynapse
A0045921biological_processpositive regulation of exocytosis
A0045956biological_processpositive regulation of calcium ion-dependent exocytosis
A0046879biological_processhormone secretion
A0048278biological_processvesicle docking
A0048306molecular_functioncalcium-dependent protein binding
A0048488biological_processsynaptic vesicle endocytosis
A0048787cellular_componentpresynaptic active zone membrane
A0070032cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
A0070033cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
A0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
A0072657biological_processprotein localization to membrane
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098793cellular_componentpresynapse
A0098815biological_processmodulation of excitatory postsynaptic potential
A0098839cellular_componentpostsynaptic density membrane
A0098978cellular_componentglutamatergic synapse
A1903530biological_processregulation of secretion by cell
A2000463biological_processpositive regulation of excitatory postsynaptic potential
B0000149molecular_functionSNARE binding
B0001669cellular_componentacrosomal vesicle
B0001956biological_processpositive regulation of neurotransmitter secretion
B0005484molecular_functionSNAP receptor activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006836biological_processneurotransmitter transport
B0006886biological_processintracellular protein transport
B0006887biological_processexocytosis
B0006906biological_processvesicle fusion
B0008021cellular_componentsynaptic vesicle
B0008076cellular_componentvoltage-gated potassium channel complex
B0009629biological_processresponse to gravity
B0010701biological_processpositive regulation of norepinephrine secretion
B0010807biological_processregulation of synaptic vesicle priming
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0016079biological_processsynaptic vesicle exocytosis
B0016081biological_processsynaptic vesicle docking
B0016192biological_processvesicle-mediated transport
B0016925biological_processprotein sumoylation
B0017022molecular_functionmyosin binding
B0017156biological_processcalcium-ion regulated exocytosis
B0017157biological_processregulation of exocytosis
B0019855molecular_functioncalcium channel inhibitor activity
B0019869molecular_functionchloride channel inhibitor activity
B0019900molecular_functionkinase binding
B0030073biological_processinsulin secretion
B0030141cellular_componentsecretory granule
B0030424cellular_componentaxon
B0030672cellular_componentsynaptic vesicle membrane
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031201cellular_componentSNARE complex
B0031410cellular_componentcytoplasmic vesicle
B0031965cellular_componentnuclear membrane
B0032028molecular_functionmyosin head/neck binding
B0032940biological_processsecretion by cell
B0032991cellular_componentprotein-containing complex
B0033605biological_processpositive regulation of catecholamine secretion
B0035493biological_processSNARE complex assembly
B0035494biological_processSNARE complex disassembly
B0042641cellular_componentactomyosin
B0042734cellular_componentpresynaptic membrane
B0042802molecular_functionidentical protein binding
B0043005cellular_componentneuron projection
B0043008molecular_functionATP-dependent protein binding
B0044325molecular_functiontransmembrane transporter binding
B0044877molecular_functionprotein-containing complex binding
B0045055biological_processregulated exocytosis
B0045202cellular_componentsynapse
B0045921biological_processpositive regulation of exocytosis
B0045956biological_processpositive regulation of calcium ion-dependent exocytosis
B0046879biological_processhormone secretion
B0048278biological_processvesicle docking
B0048306molecular_functioncalcium-dependent protein binding
B0048488biological_processsynaptic vesicle endocytosis
B0048787cellular_componentpresynaptic active zone membrane
B0070032cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
B0070033cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
B0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
B0072657biological_processprotein localization to membrane
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098793cellular_componentpresynapse
B0098815biological_processmodulation of excitatory postsynaptic potential
B0098839cellular_componentpostsynaptic density membrane
B0098978cellular_componentglutamatergic synapse
B1903530biological_processregulation of secretion by cell
B2000463biological_processpositive regulation of excitatory postsynaptic potential
C0000149molecular_functionSNARE binding
C0001917cellular_componentphotoreceptor inner segment
C0005249molecular_functionvoltage-gated potassium channel activity
C0005484molecular_functionSNAP receptor activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005802cellular_componenttrans-Golgi network
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005938cellular_componentcell cortex
C0006887biological_processexocytosis
C0006906biological_processvesicle fusion
C0007269biological_processneurotransmitter secretion
C0007409biological_processaxonogenesis
C0007616biological_processlong-term memory
C0007626biological_processlocomotory behavior
C0008021cellular_componentsynaptic vesicle
C0008076cellular_componentvoltage-gated potassium channel complex
C0008289molecular_functionlipid binding
C0008306biological_processassociative learning
C0010975biological_processregulation of neuron projection development
C0015629cellular_componentactin cytoskeleton
C0016020cellular_componentmembrane
C0016079biological_processsynaptic vesicle exocytosis
C0016082biological_processsynaptic vesicle priming
C0016197biological_processendosomal transport
C0017022molecular_functionmyosin binding
C0017075molecular_functionsyntaxin-1 binding
C0019904molecular_functionprotein domain specific binding
C0030027cellular_componentlamellipodium
C0030073biological_processinsulin secretion
C0030175cellular_componentfilopodium
C0030182biological_processneuron differentiation
C0030424cellular_componentaxon
C0030426cellular_componentgrowth cone
C0031083cellular_componentBLOC-1 complex
C0031201cellular_componentSNARE complex
C0031340biological_processpositive regulation of vesicle fusion
C0031629biological_processsynaptic vesicle fusion to presynaptic active zone membrane
C0031915biological_processpositive regulation of synaptic plasticity
C0031982cellular_componentvesicle
C0032024biological_processpositive regulation of insulin secretion
C0035493biological_processSNARE complex assembly
C0036477cellular_componentsomatodendritic compartment
C0042734cellular_componentpresynaptic membrane
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043195cellular_componentterminal bouton
C0044295cellular_componentaxonal growth cone
C0044325molecular_functiontransmembrane transporter binding
C0045202cellular_componentsynapse
C0046887biological_processpositive regulation of hormone secretion
C0048306molecular_functioncalcium-dependent protein binding
C0048471cellular_componentperinuclear region of cytoplasm
C0048791biological_processcalcium ion-regulated exocytosis of neurotransmitter
C0051963biological_processregulation of synapse assembly
C0060291biological_processlong-term synaptic potentiation
C0061025biological_processmembrane fusion
C0070032cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
C0070033cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
C0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
C0070201biological_processregulation of establishment of protein localization
C0071805biological_processpotassium ion transmembrane transport
C0097470cellular_componentribbon synapse
C0098693biological_processregulation of synaptic vesicle cycle
C0098888cellular_componentextrinsic component of presynaptic membrane
C0098978cellular_componentglutamatergic synapse
C0099525biological_processpresynaptic dense core vesicle exocytosis
C1901387biological_processpositive regulation of voltage-gated calcium channel activity
C1903296biological_processpositive regulation of glutamate secretion, neurotransmission
C1990926biological_processshort-term synaptic potentiation
D0000149molecular_functionSNARE binding
D0001917cellular_componentphotoreceptor inner segment
D0005249molecular_functionvoltage-gated potassium channel activity
D0005484molecular_functionSNAP receptor activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005802cellular_componenttrans-Golgi network
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005938cellular_componentcell cortex
D0006887biological_processexocytosis
D0006906biological_processvesicle fusion
D0007269biological_processneurotransmitter secretion
D0007409biological_processaxonogenesis
D0007616biological_processlong-term memory
D0007626biological_processlocomotory behavior
D0008021cellular_componentsynaptic vesicle
D0008076cellular_componentvoltage-gated potassium channel complex
D0008289molecular_functionlipid binding
D0008306biological_processassociative learning
D0010975biological_processregulation of neuron projection development
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0016079biological_processsynaptic vesicle exocytosis
D0016082biological_processsynaptic vesicle priming
D0016197biological_processendosomal transport
D0017022molecular_functionmyosin binding
D0017075molecular_functionsyntaxin-1 binding
D0019904molecular_functionprotein domain specific binding
D0030027cellular_componentlamellipodium
D0030073biological_processinsulin secretion
D0030175cellular_componentfilopodium
D0030182biological_processneuron differentiation
D0030424cellular_componentaxon
D0030426cellular_componentgrowth cone
D0031083cellular_componentBLOC-1 complex
D0031201cellular_componentSNARE complex
D0031340biological_processpositive regulation of vesicle fusion
D0031629biological_processsynaptic vesicle fusion to presynaptic active zone membrane
D0031915biological_processpositive regulation of synaptic plasticity
D0031982cellular_componentvesicle
D0032024biological_processpositive regulation of insulin secretion
D0035493biological_processSNARE complex assembly
D0036477cellular_componentsomatodendritic compartment
D0042734cellular_componentpresynaptic membrane
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043195cellular_componentterminal bouton
D0044295cellular_componentaxonal growth cone
D0044325molecular_functiontransmembrane transporter binding
D0045202cellular_componentsynapse
D0046887biological_processpositive regulation of hormone secretion
D0048306molecular_functioncalcium-dependent protein binding
D0048471cellular_componentperinuclear region of cytoplasm
D0048791biological_processcalcium ion-regulated exocytosis of neurotransmitter
D0051963biological_processregulation of synapse assembly
D0060291biological_processlong-term synaptic potentiation
D0061025biological_processmembrane fusion
D0070032cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
D0070033cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
D0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
D0070201biological_processregulation of establishment of protein localization
D0071805biological_processpotassium ion transmembrane transport
D0097470cellular_componentribbon synapse
D0098693biological_processregulation of synaptic vesicle cycle
D0098888cellular_componentextrinsic component of presynaptic membrane
D0098978cellular_componentglutamatergic synapse
D0099525biological_processpresynaptic dense core vesicle exocytosis
D1901387biological_processpositive regulation of voltage-gated calcium channel activity
D1903296biological_processpositive regulation of glutamate secretion, neurotransmission
D1990926biological_processshort-term synaptic potentiation
E0000149molecular_functionSNARE binding
E0005483molecular_functionsoluble NSF attachment protein activity
E0005515molecular_functionprotein binding
E0005739cellular_componentmitochondrion
E0005886cellular_componentplasma membrane
E0006886biological_processintracellular protein transport
E0007420biological_processbrain development
E0008021cellular_componentsynaptic vesicle
E0010807biological_processregulation of synaptic vesicle priming
E0015031biological_processprotein transport
E0016082biological_processsynaptic vesicle priming
E0016192biological_processvesicle-mediated transport
E0019905molecular_functionsyntaxin binding
E0030182biological_processneuron differentiation
E0030425cellular_componentdendrite
E0031410cellular_componentcytoplasmic vesicle
E0031594cellular_componentneuromuscular junction
E0032781biological_processpositive regulation of ATP-dependent activity
E0032984biological_processprotein-containing complex disassembly
E0035249biological_processsynaptic transmission, glutamatergic
E0035494biological_processSNARE complex disassembly
E0042599cellular_componentlamellar body
E0042734cellular_componentpresynaptic membrane
E0043195cellular_componentterminal bouton
E0043204cellular_componentperikaryon
E0044877molecular_functionprotein-containing complex binding
E0045176biological_processapical protein localization
E0045211cellular_componentpostsynaptic membrane
E0048787cellular_componentpresynaptic active zone membrane
E0055093biological_processresponse to hyperoxia
E0061025biological_processmembrane fusion
E0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
E0097060cellular_componentsynaptic membrane
E0098793cellular_componentpresynapse
E0098794cellular_componentpostsynapse
E0098978cellular_componentglutamatergic synapse
F0000149molecular_functionSNARE binding
F0005483molecular_functionsoluble NSF attachment protein activity
F0005515molecular_functionprotein binding
F0005739cellular_componentmitochondrion
F0005886cellular_componentplasma membrane
F0006886biological_processintracellular protein transport
F0007420biological_processbrain development
F0008021cellular_componentsynaptic vesicle
F0010807biological_processregulation of synaptic vesicle priming
F0015031biological_processprotein transport
F0016082biological_processsynaptic vesicle priming
F0016192biological_processvesicle-mediated transport
F0019905molecular_functionsyntaxin binding
F0030182biological_processneuron differentiation
F0030425cellular_componentdendrite
F0031410cellular_componentcytoplasmic vesicle
F0031594cellular_componentneuromuscular junction
F0032781biological_processpositive regulation of ATP-dependent activity
F0032984biological_processprotein-containing complex disassembly
F0035249biological_processsynaptic transmission, glutamatergic
F0035494biological_processSNARE complex disassembly
F0042599cellular_componentlamellar body
F0042734cellular_componentpresynaptic membrane
F0043195cellular_componentterminal bouton
F0043204cellular_componentperikaryon
F0044877molecular_functionprotein-containing complex binding
F0045176biological_processapical protein localization
F0045211cellular_componentpostsynaptic membrane
F0048787cellular_componentpresynaptic active zone membrane
F0055093biological_processresponse to hyperoxia
F0061025biological_processmembrane fusion
F0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
F0097060cellular_componentsynaptic membrane
F0098793cellular_componentpresynapse
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
G0000149molecular_functionSNARE binding
G0005483molecular_functionsoluble NSF attachment protein activity
G0005515molecular_functionprotein binding
G0005739cellular_componentmitochondrion
G0005886cellular_componentplasma membrane
G0006886biological_processintracellular protein transport
G0007420biological_processbrain development
G0008021cellular_componentsynaptic vesicle
G0010807biological_processregulation of synaptic vesicle priming
G0015031biological_processprotein transport
G0016082biological_processsynaptic vesicle priming
G0016192biological_processvesicle-mediated transport
G0019905molecular_functionsyntaxin binding
G0030182biological_processneuron differentiation
G0030425cellular_componentdendrite
G0031410cellular_componentcytoplasmic vesicle
G0031594cellular_componentneuromuscular junction
G0032781biological_processpositive regulation of ATP-dependent activity
G0032984biological_processprotein-containing complex disassembly
G0035249biological_processsynaptic transmission, glutamatergic
G0035494biological_processSNARE complex disassembly
G0042599cellular_componentlamellar body
G0042734cellular_componentpresynaptic membrane
G0043195cellular_componentterminal bouton
G0043204cellular_componentperikaryon
G0044877molecular_functionprotein-containing complex binding
G0045176biological_processapical protein localization
G0045211cellular_componentpostsynaptic membrane
G0048787cellular_componentpresynaptic active zone membrane
G0055093biological_processresponse to hyperoxia
G0061025biological_processmembrane fusion
G0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
G0097060cellular_componentsynaptic membrane
G0098793cellular_componentpresynapse
G0098794cellular_componentpostsynapse
G0098978cellular_componentglutamatergic synapse
H0000149molecular_functionSNARE binding
H0005483molecular_functionsoluble NSF attachment protein activity
H0005515molecular_functionprotein binding
H0005739cellular_componentmitochondrion
H0005886cellular_componentplasma membrane
H0006886biological_processintracellular protein transport
H0007420biological_processbrain development
H0008021cellular_componentsynaptic vesicle
H0010807biological_processregulation of synaptic vesicle priming
H0015031biological_processprotein transport
H0016082biological_processsynaptic vesicle priming
H0016192biological_processvesicle-mediated transport
H0019905molecular_functionsyntaxin binding
H0030182biological_processneuron differentiation
H0030425cellular_componentdendrite
H0031410cellular_componentcytoplasmic vesicle
H0031594cellular_componentneuromuscular junction
H0032781biological_processpositive regulation of ATP-dependent activity
H0032984biological_processprotein-containing complex disassembly
H0035249biological_processsynaptic transmission, glutamatergic
H0035494biological_processSNARE complex disassembly
H0042599cellular_componentlamellar body
H0042734cellular_componentpresynaptic membrane
H0043195cellular_componentterminal bouton
H0043204cellular_componentperikaryon
H0044877molecular_functionprotein-containing complex binding
H0045176biological_processapical protein localization
H0045211cellular_componentpostsynaptic membrane
H0048787cellular_componentpresynaptic active zone membrane
H0055093biological_processresponse to hyperoxia
H0061025biological_processmembrane fusion
H0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
H0097060cellular_componentsynaptic membrane
H0098793cellular_componentpresynapse
H0098794cellular_componentpostsynapse
H0098978cellular_componentglutamatergic synapse
Functional Information from PROSITE/UniProt
site_idPS00914
Number of Residues40
DetailsSYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V
ChainResidueDetails
AARG198-VAL237

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues124
DetailsDomain: {"description":"t-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C)","evidences":[{"source":"PubMed","id":"7737992","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q16623","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues124
DetailsDomain: {"description":"t-SNARE coiled-coil homology 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P60879","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P54920","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9DB05","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P54920","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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