9OF0
Cryo-EM Structure of Human HIF-2a-ARNT Complexed on 20-bp HRE
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 53 |
| Details | Domain: {"description":"bHLH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00981","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 70 |
| Details | Domain: {"description":"PAS 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00140","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 43 |
| Details | Domain: {"description":"PAC"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"UniProtKB","id":"P97481","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | Region: {"description":"Required for heterodimer formation with ARNT","evidences":[{"source":"UniProtKB","id":"P97481","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Region: {"description":"Mediates the transcription activity and dimerization of the AHR:ARNT complex","evidences":[{"source":"UniProtKB","id":"P53762","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
