9NX2
Muscle-type nicotinic acetylcholine receptor bound to conotoxin ImII
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0042391 | biological_process | regulation of membrane potential |
| A | 0045211 | cellular_component | postsynaptic membrane |
| A | 0060078 | biological_process | regulation of postsynaptic membrane potential |
| A | 0060079 | biological_process | excitatory postsynaptic potential |
| A | 0099565 | biological_process | chemical synaptic transmission, postsynaptic |
| B | 0003008 | biological_process | system process |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0045211 | cellular_component | postsynaptic membrane |
| B | 0060078 | biological_process | regulation of postsynaptic membrane potential |
| B | 0060079 | biological_process | excitatory postsynaptic potential |
| B | 0099565 | biological_process | chemical synaptic transmission, postsynaptic |
| C | 0003008 | biological_process | system process |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007165 | biological_process | signal transduction |
| C | 0007268 | biological_process | chemical synaptic transmission |
| C | 0045211 | cellular_component | postsynaptic membrane |
| C | 0060078 | biological_process | regulation of postsynaptic membrane potential |
| C | 0060079 | biological_process | excitatory postsynaptic potential |
| C | 0099565 | biological_process | chemical synaptic transmission, postsynaptic |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0007268 | biological_process | chemical synaptic transmission |
| D | 0042391 | biological_process | regulation of membrane potential |
| D | 0045211 | cellular_component | postsynaptic membrane |
| D | 0060078 | biological_process | regulation of postsynaptic membrane potential |
| D | 0060079 | biological_process | excitatory postsynaptic potential |
| D | 0099565 | biological_process | chemical synaptic transmission, postsynaptic |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0007268 | biological_process | chemical synaptic transmission |
| E | 0042391 | biological_process | regulation of membrane potential |
| E | 0045211 | cellular_component | postsynaptic membrane |
| E | 0060078 | biological_process | regulation of postsynaptic membrane potential |
| E | 0060079 | biological_process | excitatory postsynaptic potential |
| E | 0098960 | molecular_function | postsynaptic neurotransmitter receptor activity |
| E | 0099565 | biological_process | chemical synaptic transmission, postsynaptic |
| E | 1904315 | molecular_function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CtIkVmyFPfDwqnC |
| Chain | Residue | Details |
| C | CYS128-CYS142 | |
| B | CYS130-CYS144 | |
| A | CYS128-CYS142 | |
| E | CYS128-CYS142 |
| site_id | PS60014 |
| Number of Residues | 11 |
| Details | ALPHA_CONOTOXIN Alpha-conotoxin family signature. CCSdRRCR....WRC |
| Chain | Residue | Details |
| F | CYS2-CYS12 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 635 |
| Details | Topological domain: {"description":"Extracellular"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 308 |
| Details | Transmembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"2742850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6585820","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"2742850","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 215 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 81 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | Peptide: {"description":"Alpha-conotoxin ImII","featureId":"PRO_0000034878","evidences":[{"source":"PubMed","id":"12384509","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Cysteine amide","evidences":[{"source":"PubMed","id":"12384509","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
